Chemical modification strategies for viscosity-dependent processing of gellan gum

Christine Gering, Anum Rasheed, Janne Koivisto, Jenny Parraga Meneses, Sampo Tuukkanen, Minna Kellomäki

Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

8 Lataukset (Pure)

Abstrakti

Recently, the hydrogel-forming polysaccharide gellan gum (GG) has gained popularity as a versatile biomaterial for tissue engineering purposes. Here, we examine the modification strategies suitable for GG to overcome processing-related limitations. We emphasize the thorough assessment of the viscoelastic and mechanical properties of both precursor solutions and final hydrogels. The investigated modification strategies include purification, oxidation, reductive chain scission, and blending. We correlate polymer flow and hydrogel forming capabilities to viscosity-dependent methods including casting, injection and printing. Native GG and purified NaGG are shear thinning and feasible for printing, being similar in gelation and compression behavior. Oxidized GGox possesses reduced viscosity, higher toughness, and aldehydes as functional groups, while scissored GGsciss has markedly lower molecular weight. To exemplify extrudability, select modification products are printed using an extrusion-based bioprinter utilizing a crosslinker bath. Our robust modification strategies have widened the processing capabilities of GG without affecting its ability to form hydrogels.
AlkuperäiskieliEnglanti
Artikkeli118335
JulkaisuCarbohydrate Polymers
Vuosikerta269
Varhainen verkossa julkaisun päivämäärä22 kesäk. 2021
DOI - pysyväislinkit
TilaJulkaistu - lokak. 2021
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

  • Jufo-taso 1

Sormenjälki

Sukella tutkimusaiheisiin 'Chemical modification strategies for viscosity-dependent processing of gellan gum'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.

Siteeraa tätä