Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake

Feitong Wu; Katja Pahkala; Markus Juonala; Suvi P. Rovio; Matthew A. Sabin; Tapani Rönnemaa; Kylie J. Smith; Antti Jula; Terho Lehtimäki; Nina Hutri-Kähönen; Mika Kähönen; Tomi Laitinen; Jorma S.A. Viikari; Olli T. Raitakari; Costan G. Magnussen

doi:10.1016/j.clnu.2020.09.007

Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake

Feitong Wu^*
, Katja Pahkala
, Markus Juonala
, Suvi P. Rovio
, Matthew A. Sabin
, Tapani Rönnemaa
, Kylie J. Smith
, Antti Jula
, Terho Lehtimäki
, Nina Hutri-Kähönen
, Mika Kähönen
, Tomi Laitinen
, Jorma S.A. Viikari
, Olli T. Raitakari
, Costan G. Magnussen

^*Tämän työn vastaava kirjoittaja

Kliinisen kemian yksikkö

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

7 Sitaatiot (Scopus)

Abstrakti

Background & aims: The influence of dietary calcium intake in childhood on adult cardiovascular health is unknown, particularly in those with long-term high intake. To examine both linear and non-linear associations of childhood and long-term (between childhood and adulthood) dietary calcium intake with adult cardiovascular risk outcomes. Methods: A population-based prospective cohort study in Finland (n = 1029, aged 3–18 years at baseline). Dietary calcium intake was assessed in childhood (1980, baseline) and adulthood (mean of available data from 2001, 2007 and 2011). Long-term dietary calcium intake was calculated as the mean between childhood and adulthood. Outcomes were measured in 2001, 2007, and/or 2011, and the latest available data were used for analyses, including high carotid intima-media thickness, hypertension, low high-density lipoprotein cholesterol, high low-density lipoprotein cholesterol and triglycerides, arterial pulse wave velocity (PWV), carotid artery compliance (CAC), Young's elastic modulus (YEM), and stiffness index (SI). Results: There were no significant non-linear or linear associations between childhood or long-term dietary calcium intake with any adult cardiovascular outcomes, after adjustment for age, sex, and childhood and adulthood confounders (e.g., body mass index, systolic blood pressure, smoking, physical activity, fruit and vegetable consumption). Conclusions: Childhood or long-term dietary calcium intake that is higher than the recommended level is not associated with increased cardiovascular risk in adulthood.

Alkuperäiskieli	Englanti
Sivut	1926-1931
Julkaisu	Clinical Nutrition
Vuosikerta	40
Numero	4
Varhainen verkossa julkaisun päivämäärä	18 syysk. 2020
DOI - pysyväislinkit	https://doi.org/10.1016/j.clnu.2020.09.007
Tila	Julkaistu - huhtik. 2021
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

The Young Finns Study has been financially supported by the Academy of Finland : grants 322098 , 286284 , 134309 (Eye), 126925 , 121584 , 124282 , 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland ; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001 ); Juho Vainio Foundation ; Paavo Nurmi Foundation ; Finnish Foundation for Cardiovascular Research ; Finnish Cultural Foundation ; The Sigrid Juselius Foundation ; Tampere Tuberculosis Foundation ; Emil Aaltonen Foundation ; Yrjö Jahnsson Foundation ; Signe and Ane Gyllenberg Foundation ; Diabetes Research Foundation of Finnish Diabetes Association ; and EU Horizon 2020 (grant 755320 for TAXINOMISIS); and European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation . This study was supported by a grant from the National Health and Medical Research Council Project Grant ( APP1098369 ). FW is supported by a National Health and Medical Research Council Early Career Fellowship ( APP1158661 ) and a 2019 Australian Endeavour Research Leadership Award ( ERLA_PDR_235352_2018 ). KJS is supported by NHMRC Early Career Fellowship ( APP1072516 ). CGM was supported by a National Heart Foundation of Australia Future Leader Fellowship ( 100849 ). They did not have any role in the study concept, design, data analysis, writing of the manuscript, or submission of the manuscript for publication. The researchers are totally independent of the funders.

Julkaisufoorumi-taso

Jufo-taso 2

!!ASJC Scopus subject areas

Nutrition and Dietetics
Critical Care and Intensive Care Medicine

Pääsy asiakirjaan

10.1016/j.clnu.2020.09.007

https://erepo.uef.fi/handle/123456789/24917

Siteeraa tätä

Wu, F., Pahkala, K., Juonala, M., Rovio, S. P., Sabin, M. A., Rönnemaa, T., Smith, K. J., Jula, A., Lehtimäki, T., Hutri-Kähönen, N., Kähönen, M., Laitinen, T., Viikari, J. S. A., Raitakari, O. T., & Magnussen, C. G. (2021). Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake. Clinical Nutrition, 40(4), 1926-1931. https://doi.org/10.1016/j.clnu.2020.09.007

@article{dbb4010d312b4a61b9fa4db7fd91cd9b,

title = "Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake",

abstract = "Background \& aims: The influence of dietary calcium intake in childhood on adult cardiovascular health is unknown, particularly in those with long-term high intake. To examine both linear and non-linear associations of childhood and long-term (between childhood and adulthood) dietary calcium intake with adult cardiovascular risk outcomes. Methods: A population-based prospective cohort study in Finland (n = 1029, aged 3{\textendash}18 years at baseline). Dietary calcium intake was assessed in childhood (1980, baseline) and adulthood (mean of available data from 2001, 2007 and 2011). Long-term dietary calcium intake was calculated as the mean between childhood and adulthood. Outcomes were measured in 2001, 2007, and/or 2011, and the latest available data were used for analyses, including high carotid intima-media thickness, hypertension, low high-density lipoprotein cholesterol, high low-density lipoprotein cholesterol and triglycerides, arterial pulse wave velocity (PWV), carotid artery compliance (CAC), Young's elastic modulus (YEM), and stiffness index (SI). Results: There were no significant non-linear or linear associations between childhood or long-term dietary calcium intake with any adult cardiovascular outcomes, after adjustment for age, sex, and childhood and adulthood confounders (e.g., body mass index, systolic blood pressure, smoking, physical activity, fruit and vegetable consumption). Conclusions: Childhood or long-term dietary calcium intake that is higher than the recommended level is not associated with increased cardiovascular risk in adulthood.",

keywords = "Cardiovascular risk, Cohort, Dietary calcium intake, Paediatric",

author = "Feitong Wu and Katja Pahkala and Markus Juonala and Rovio, \{Suvi P.\} and Sabin, \{Matthew A.\} and Tapani R{\"o}nnemaa and Smith, \{Kylie J.\} and Antti Jula and Terho Lehtim{\"a}ki and Nina Hutri-K{\"a}h{\"o}nen and Mika K{\"a}h{\"o}nen and Tomi Laitinen and Viikari, \{Jorma S.A.\} and Raitakari, \{Olli T.\} and Magnussen, \{Costan G.\}",

note = "Funding Information: The Young Finns Study has been financially supported by the Academy of Finland : grants 322098 , 286284 , 134309 (Eye), 126925 , 121584 , 124282 , 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland ; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001 ); Juho Vainio Foundation ; Paavo Nurmi Foundation ; Finnish Foundation for Cardiovascular Research ; Finnish Cultural Foundation ; The Sigrid Juselius Foundation ; Tampere Tuberculosis Foundation ; Emil Aaltonen Foundation ; Yrj{\"o} Jahnsson Foundation ; Signe and Ane Gyllenberg Foundation ; Diabetes Research Foundation of Finnish Diabetes Association ; and EU Horizon 2020 (grant 755320 for TAXINOMISIS); and European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation . This study was supported by a grant from the National Health and Medical Research Council Project Grant ( APP1098369 ). FW is supported by a National Health and Medical Research Council Early Career Fellowship ( APP1158661 ) and a 2019 Australian Endeavour Research Leadership Award ( ERLA\_PDR\_235352\_2018 ). KJS is supported by NHMRC Early Career Fellowship ( APP1072516 ). CGM was supported by a National Heart Foundation of Australia Future Leader Fellowship ( 100849 ). They did not have any role in the study concept, design, data analysis, writing of the manuscript, or submission of the manuscript for publication. The researchers are totally independent of the funders. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2021",

month = apr,

doi = "10.1016/j.clnu.2020.09.007",

language = "English",

volume = "40",

pages = "1926--1931",

journal = "Clinical Nutrition",

issn = "0261-5614",

publisher = "Churchill Livingstone",

number = "4",

}

Wu, F, Pahkala, K, Juonala, M, Rovio, SP, Sabin, MA, Rönnemaa, T, Smith, KJ, Jula, A, Lehtimäki, T, Hutri-Kähönen, N, Kähönen, M, Laitinen, T, Viikari, JSA, Raitakari, OT & Magnussen, CG 2021, 'Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake', Clinical Nutrition, Vuosikerta 40, Nro 4, Sivut 1926-1931. https://doi.org/10.1016/j.clnu.2020.09.007

TY - JOUR

T1 - Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake

AU - Wu, Feitong

AU - Pahkala, Katja

AU - Juonala, Markus

AU - Rovio, Suvi P.

AU - Sabin, Matthew A.

AU - Rönnemaa, Tapani

AU - Smith, Kylie J.

AU - Jula, Antti

AU - Lehtimäki, Terho

AU - Hutri-Kähönen, Nina

AU - Kähönen, Mika

AU - Laitinen, Tomi

AU - Viikari, Jorma S.A.

AU - Raitakari, Olli T.

AU - Magnussen, Costan G.

N1 - Funding Information: The Young Finns Study has been financially supported by the Academy of Finland : grants 322098 , 286284 , 134309 (Eye), 126925 , 121584 , 124282 , 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland ; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001 ); Juho Vainio Foundation ; Paavo Nurmi Foundation ; Finnish Foundation for Cardiovascular Research ; Finnish Cultural Foundation ; The Sigrid Juselius Foundation ; Tampere Tuberculosis Foundation ; Emil Aaltonen Foundation ; Yrjö Jahnsson Foundation ; Signe and Ane Gyllenberg Foundation ; Diabetes Research Foundation of Finnish Diabetes Association ; and EU Horizon 2020 (grant 755320 for TAXINOMISIS); and European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation . This study was supported by a grant from the National Health and Medical Research Council Project Grant ( APP1098369 ). FW is supported by a National Health and Medical Research Council Early Career Fellowship ( APP1158661 ) and a 2019 Australian Endeavour Research Leadership Award ( ERLA_PDR_235352_2018 ). KJS is supported by NHMRC Early Career Fellowship ( APP1072516 ). CGM was supported by a National Heart Foundation of Australia Future Leader Fellowship ( 100849 ). They did not have any role in the study concept, design, data analysis, writing of the manuscript, or submission of the manuscript for publication. The researchers are totally independent of the funders. Publisher Copyright: © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - Background & aims: The influence of dietary calcium intake in childhood on adult cardiovascular health is unknown, particularly in those with long-term high intake. To examine both linear and non-linear associations of childhood and long-term (between childhood and adulthood) dietary calcium intake with adult cardiovascular risk outcomes. Methods: A population-based prospective cohort study in Finland (n = 1029, aged 3–18 years at baseline). Dietary calcium intake was assessed in childhood (1980, baseline) and adulthood (mean of available data from 2001, 2007 and 2011). Long-term dietary calcium intake was calculated as the mean between childhood and adulthood. Outcomes were measured in 2001, 2007, and/or 2011, and the latest available data were used for analyses, including high carotid intima-media thickness, hypertension, low high-density lipoprotein cholesterol, high low-density lipoprotein cholesterol and triglycerides, arterial pulse wave velocity (PWV), carotid artery compliance (CAC), Young's elastic modulus (YEM), and stiffness index (SI). Results: There were no significant non-linear or linear associations between childhood or long-term dietary calcium intake with any adult cardiovascular outcomes, after adjustment for age, sex, and childhood and adulthood confounders (e.g., body mass index, systolic blood pressure, smoking, physical activity, fruit and vegetable consumption). Conclusions: Childhood or long-term dietary calcium intake that is higher than the recommended level is not associated with increased cardiovascular risk in adulthood.

AB - Background & aims: The influence of dietary calcium intake in childhood on adult cardiovascular health is unknown, particularly in those with long-term high intake. To examine both linear and non-linear associations of childhood and long-term (between childhood and adulthood) dietary calcium intake with adult cardiovascular risk outcomes. Methods: A population-based prospective cohort study in Finland (n = 1029, aged 3–18 years at baseline). Dietary calcium intake was assessed in childhood (1980, baseline) and adulthood (mean of available data from 2001, 2007 and 2011). Long-term dietary calcium intake was calculated as the mean between childhood and adulthood. Outcomes were measured in 2001, 2007, and/or 2011, and the latest available data were used for analyses, including high carotid intima-media thickness, hypertension, low high-density lipoprotein cholesterol, high low-density lipoprotein cholesterol and triglycerides, arterial pulse wave velocity (PWV), carotid artery compliance (CAC), Young's elastic modulus (YEM), and stiffness index (SI). Results: There were no significant non-linear or linear associations between childhood or long-term dietary calcium intake with any adult cardiovascular outcomes, after adjustment for age, sex, and childhood and adulthood confounders (e.g., body mass index, systolic blood pressure, smoking, physical activity, fruit and vegetable consumption). Conclusions: Childhood or long-term dietary calcium intake that is higher than the recommended level is not associated with increased cardiovascular risk in adulthood.

KW - Cardiovascular risk

KW - Cohort

KW - Dietary calcium intake

KW - Paediatric

U2 - 10.1016/j.clnu.2020.09.007

DO - 10.1016/j.clnu.2020.09.007

M3 - Article

AN - SCOPUS:85091686543

SN - 0261-5614

VL - 40

SP - 1926

EP - 1931

JO - Clinical Nutrition

JF - Clinical Nutrition

IS - 4

ER -

Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake

Abstrakti

Rahoitus

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

Siteeraa tätä