TY - JOUR
T1 - Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity
AU - Niinistö, Sari
AU - Erlund, Iris
AU - Lee, Hye Seung
AU - Uusitalo, Ulla
AU - Salminen, Irma
AU - Aronsson, Carin Andrén
AU - Parikh, Hemang M.
AU - Liu, Xiang
AU - Hummel, Sandra
AU - Toppari, Jorma
AU - She, Jin Xiong
AU - Lernmark, Åke
AU - Ziegler, Annette G.
AU - Rewers, Marian
AU - Akolkar, Beena
AU - Krischer, Jeffrey P.
AU - Galas, David
AU - Das, Siba
AU - Sakhanenko, Nikita
AU - Rich, Stephen S.
AU - Hagopian, William
AU - Norris, Jill M.
AU - Virtanen, Suvi M.
AU - The TEDDY Study Group.
AU - Barbour, Aaron
AU - Bautista, Kimberly
AU - Baxter, Judith
AU - Felipe-Morales, Daniel
AU - Driscoll, Kimberly
AU - Frohnert, Brigitte I.
AU - Stahl, Marisa
AU - Gesualdo, Patricia
AU - Hoffman, Michelle
AU - Karban, Rachel
AU - Liu, Edwin
AU - Peacock, Stesha
AU - Ahonen, Suvi
AU - Åkerlund, Mari
AU - Hakola, Leena
AU - Hyöty, Heikki
AU - Knip, Mikael
AU - Koreasalo, Mirva
AU - Kurppa, Kalle
AU - Lindfors, Katri
AU - Lönnrot, Maria
AU - Mattila, Markus
AU - Niininen, Tiina
AU - Nyblom, Mia
AU - Oikarinen, Sami
AU - Riikonen, Anne
AU - Tossavainen, Päivi
N1 - Funding Information:
The TEDDY Study is funded by U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483, and Contract No. HHSN267200700014C from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Environmental Health Sciences (NIEHS), Centers for Disease Control and Prevention (CDC), and JDRF. This work supported in part by the NIH/NCATS Clinical and Translational Science Awards to the University of Florida (UL1 TR000064) and the University of Colorado (UL1 TR001082) as well as by the Academy of Finland (Grant 276475). Role of the funder/sponsor: The sponsors of this study were represented on the Steering Committee and played a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The corresponding author had the final decision to submit the manuscript for publication.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/2
Y1 - 2021/2
N2 - Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case–control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n − 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n − 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.
AB - Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case–control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n − 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n − 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.
U2 - 10.1038/s41598-021-82200-9
DO - 10.1038/s41598-021-82200-9
M3 - Article
C2 - 33574451
AN - SCOPUS:85101050436
SN - 2045-2322
VL - 11
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 3627
ER -