Circulating tumor DNA is a prognostic biomarker in metastatic melanoma patients treated with chemoimmunotherapy and BRAF inhibitor

Kalle E. Mattila, Siru Mäkelä, Soili Kytölä, Emma Andersson, Pia Vihinen, Susan Ramadan, Tanja Skyttä, Leena Tiainen, Meri Sisko Vuoristo, Kristiina Tyynelä-Korhonen, Jussi Koivunen, Laura Kohtamäki, Kristiina Aittomäki, Micaela Hernberg

    Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

    Abstrakti

    Background: Detectable circulating tumor DNA (ctDNA) has been associated with worse prognosis in melanoma patients. Material and methods: We studied plasma ctDNA as a prognostic biomarker in 19 patients with metastatic melanoma and a detectable tumor mutation (13 BRAF, 5 NRAS, and 1 KRAS). Patients had received chemotherapy, interferon-alpha, and vemurafenib in a prospective clinical trial. Mutant allele frequency (MAF %) was determined with droplet digital PCR from pretreatment and sequential plasma samples. Results: Higher pretreatment plasma ctDNA levels (MAF ≥3%) and detectable plasma ctDNA levels (MAF >0%) at the time of radiologically confirmed best objective response were associated with poor prognosis even when accounting for other relevant prognostic factors including performance status, tumor mutation, metastasis stage, and lactate dehydrogenase levels in multivariable analysis. Conclusion: Higher pretreatment plasma ctDNA levels and sustained detectable plasma ctDNA levels during treatment indicated poor prognosis in metastatic melanoma patients.

    AlkuperäiskieliEnglanti
    Sivut1263-1267
    Sivumäärä5
    JulkaisuActa Oncologica
    Vuosikerta61
    Numero10
    DOI - pysyväislinkit
    TilaJulkaistu - 2022
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

    Julkaisufoorumi-taso

    • Jufo-taso 1

    !!ASJC Scopus subject areas

    • Hematology
    • Oncology
    • Radiology Nuclear Medicine and imaging

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