Claudins as prognostic factors for renal cell cancer

Juha Virman, Ylermi Soini, Paula Kujala, Tiina Luukkaala, Tapio Salminen, Kaisa Sunela, Pirkko Liisa Kellokumpu-Lehtinen

Tutkimustuotos: ArtikkeliTieteellinenvertaisarvioitu

10 Sitaatiot (Scopus)

Abstrakti

Background: Claudins are tight junction proteins and their expression is often different in normal and corresponding tumor cells. In the present study, we determined how the expression of claudins 1-5 and 7 correlated to survival, grade and stage of patients with renal cell cancer (RCC). Patients and Methods: Primary tumor samples were collected retrospectively from 229 RCC patients. Claudins were detected by immunohistochemistry using commercial monoclonal antibodies against claudins 1-5 and 7. Median survival time was 6.5 years confidence interval (CI) (4.5-8.5, n=224). Kaplan-Meier survival estimated method was used in survival analyses. Results: Positive expression was detected in 62%, 67%, 45%, 55%, 7% and 35% of cases for claudins 1, 2, 3, 4, 5 and 7, respectively. High expression of claudin 2 was observed in 20% of cases while high expression of other claudins was less frequent. Claudins were compared to classical prognostic factors. On cross-tabulation, claudin 1 (p

AlkuperäiskieliEnglanti
Sivut4181-4188
Sivumäärä8
JulkaisuAnticancer Research
Vuosikerta34
Numero8
TilaJulkaistu - 2014
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Tutkimusalat

  • Claudins
  • Expression
  • Prognostic factors
  • Renal cell cancer (RCC)

Julkaisufoorumi-taso

  • Jufo-taso 1

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