Coagulopathy in acute Puumala hantavirus infection

Sirpa Koskela, Satu Mäkelä, Tomas Strandin, Antti Vaheri, Tuula Outinen, Lotta Joutsi-Korhonen, Ilkka Pörsti, Jukka Mustonen, Outi Laine

Tutkimustuotos: Review ArticleScientificvertaisarvioitu

1 Lataukset (Pure)

Abstrakti

Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.

AlkuperäiskieliEnglanti
Artikkeli1553
JulkaisuViruses
Vuosikerta13
Numero8
DOI - pysyväislinkit
TilaJulkaistu - elok. 2021
OKM-julkaisutyyppiA2 Katsausartikkeli

Julkaisufoorumi-taso

  • Jufo-taso 1

!!ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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