Coeliac disease: what can we learn from prospective studies about disease risk?

Marisa Stahl; Sibylle Koletzko; Carin Andrén Aronsson; Katri Lindfors; Edwin Liu; Daniel Agardh; TEDDY Study Group

doi:10.1016/S2352-4642(23)00232-8

Coeliac disease: what can we learn from prospective studies about disease risk?

Marisa Stahl, Sibylle Koletzko, Carin Andrén Aronsson, Katri Lindfors, Edwin Liu, Daniel Agardh, TEDDY Study Group

Tutkimustuotos: Katsausartikkeli › vertaisarvioitu

9 Sitaatiot (Scopus)

64 Lataukset (Pure)

Abstrakti

Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study complex interactions between genetic and environmental factors and thereby further our insight into the causes of the disease. In the future, paediatric prospective studies will be able to provide more detailed risk prediction models combining genes, the environment, and biological corroboration from multiomics. Such studies could also contribute to biomarker development and an improved understanding of disease pathogenesis.

Alkuperäiskieli	Englanti
Sivut	63-74
Sivumäärä	12
Julkaisu	The Lancet. Child and adolescent health
Vuosikerta	8
Numero	1
Varhainen verkossa julkaisun päivämäärä	13 marrask. 2023
DOI - pysyväislinkit	https://doi.org/10.1016/S2352-4642(23)00232-8
Tila	Julkaistu - 2024
OKM-julkaisutyyppi	A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

Jufo-taso 3

Pääsy asiakirjaan

10.1016/S2352-4642(23)00232-8

Coeliac DiseaseAccepted author manuscript, 186 KBLisenssi: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-202401111365Lisenssi: CC BY-NC-ND

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@article{18d65e95424a49e5a033ff8497b48215,

title = "Coeliac disease: what can we learn from prospective studies about disease risk?",

abstract = "Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study complex interactions between genetic and environmental factors and thereby further our insight into the causes of the disease. In the future, paediatric prospective studies will be able to provide more detailed risk prediction models combining genes, the environment, and biological corroboration from multiomics. Such studies could also contribute to biomarker development and an improved understanding of disease pathogenesis.",

author = "Marisa Stahl and Sibylle Koletzko and {Andr{\'e}n Aronsson}, Carin and Katri Lindfors and Edwin Liu and Daniel Agardh and {TEDDY Study Group} and Sami Oikarinen and Maria L{\"o}nnrot and Mirva Koreasalo and Kalle Kurppa and Leena Hakola and Suvi Ahonen and Mari {\AA}kerlund and Markus Mattila and Suvi Virtanen and Heikki Hy{\"o}ty",

year = "2024",

doi = "10.1016/S2352-4642(23)00232-8",

language = "English",

volume = "8",

pages = "63--74",

number = "1",

}

TY - JOUR

T1 - Coeliac disease

T2 - what can we learn from prospective studies about disease risk?

AU - Stahl, Marisa

AU - Koletzko, Sibylle

AU - Andrén Aronsson, Carin

AU - Lindfors, Katri

AU - Liu, Edwin

AU - Agardh, Daniel

AU - TEDDY Study Group

AU - Oikarinen, Sami

AU - Lönnrot, Maria

AU - Koreasalo, Mirva

AU - Kurppa, Kalle

AU - Hakola, Leena

AU - Ahonen, Suvi

AU - Åkerlund, Mari

AU - Mattila, Markus

AU - Virtanen, Suvi

AU - Hyöty, Heikki

PY - 2024

Y1 - 2024

N2 - Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study complex interactions between genetic and environmental factors and thereby further our insight into the causes of the disease. In the future, paediatric prospective studies will be able to provide more detailed risk prediction models combining genes, the environment, and biological corroboration from multiomics. Such studies could also contribute to biomarker development and an improved understanding of disease pathogenesis.

AB - Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study complex interactions between genetic and environmental factors and thereby further our insight into the causes of the disease. In the future, paediatric prospective studies will be able to provide more detailed risk prediction models combining genes, the environment, and biological corroboration from multiomics. Such studies could also contribute to biomarker development and an improved understanding of disease pathogenesis.

U2 - 10.1016/S2352-4642(23)00232-8

DO - 10.1016/S2352-4642(23)00232-8

M3 - Review Article

C2 - 37972632

SN - 2352-4642

VL - 8

SP - 63

EP - 74

JO - The Lancet. Child and adolescent health

JF - The Lancet. Child and adolescent health

IS - 1

ER -

Coeliac disease: what can we learn from prospective studies about disease risk?

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