Common features of chromatin in aging and cancer: Cause or coincidence?

Linda Zane; Vivek Sharma; Tom Misteli

doi:10.1016/j.tcb.2014.07.001

Common features of chromatin in aging and cancer: Cause or coincidence?

Linda Zane
, Vivek Sharma
, Tom Misteli^*

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Katsausartikkeli › vertaisarvioitu

61 Sitaatiot (Scopus)

Abstrakti

Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

Alkuperäiskieli	Englanti
Sivut	686-694
Sivumäärä	9
Julkaisu	Trends in Cell Biology
Vuosikerta	24
Numero	11
DOI - pysyväislinkit	https://doi.org/10.1016/j.tcb.2014.07.001
Tila	Julkaistu - 2014
OKM-julkaisutyyppi	A2 Katsausartikkeli tieteellisessä aikakauslehdessä

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 3 – Hyvä terveys ja hyvinvointi

!!ASJC Scopus subject areas

Cell Biology
Yleinen lääketiede

Pääsy asiakirjaan

10.1016/j.tcb.2014.07.001

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Link to publication in Scopus

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@article{e03d900e1f6e46cba26ddf26bafe8f7e,

title = "Common features of chromatin in aging and cancer: Cause or coincidence?",

abstract = "Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.",

author = "Linda Zane and Vivek Sharma and Tom Misteli",

year = "2014",

doi = "10.1016/j.tcb.2014.07.001",

language = "English",

volume = "24",

pages = "686--694",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier",

number = "11",

}

TY - JOUR

T1 - Common features of chromatin in aging and cancer

T2 - Cause or coincidence?

AU - Zane, Linda

AU - Sharma, Vivek

AU - Misteli, Tom

PY - 2014

Y1 - 2014

N2 - Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

AB - Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

UR - https://www.scopus.com/pages/publications/84927698872

U2 - 10.1016/j.tcb.2014.07.001

DO - 10.1016/j.tcb.2014.07.001

M3 - Review Article

C2 - 25103681

AN - SCOPUS:84927698872

SN - 0962-8924

VL - 24

SP - 686

EP - 694

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 11

ER -

Common features of chromatin in aging and cancer: Cause or coincidence?

Abstrakti

YK:n kestävän kehityksen tavoitteet

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Muut tiedostot ja linkit

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