Computational modeling of neuron–glia signaling interactions to unravel cellular and neural circuit functioning

Marja Leena Linne

doi:10.1016/j.conb.2023.102838

Computational modeling of neuron–glia signaling interactions to unravel cellular and neural circuit functioning

Marja Leena Linne^*

^*Tämän työn vastaava kirjoittaja

Biolääketiede

Tutkimustuotos: Katsausartikkeli › vertaisarvioitu

8 Sitaatiot (Scopus)

Abstrakti

Glial cells have been shown to be vital for various brain functions, including homeostasis, information processing, and cognition. Over the past 30 years, various signaling interactions between neuronal and glial cells have been shown to underlie these functions. This review summarizes the interactions, particularly between neurons and astrocytes, which are types of glial cells. Some of the interactions remain controversial in part due to the nature of experimental methods and preparations used. Based on the accumulated data, computational models of the neuron–astrocyte interactions have been developed to explain the complex functions of astrocytes in neural circuits and to test conflicting hypotheses. This review presents the most significant recent models, modeling methods and simulation tools for neuron–astrocyte interactions. In the future, we will especially need more experimental research on awake animals in vivo and new computational models of neuron–glia interactions to advance our understanding of cellular dynamics and the functioning of neural circuits in different brain regions.

Alkuperäiskieli	Englanti
Artikkeli	102838
Sivumäärä	9
Julkaisu	Current Opinion in Neurobiology
Vuosikerta	85
DOI - pysyväislinkit	https://doi.org/10.1016/j.conb.2023.102838
Tila	Julkaistu - huhtik. 2024
OKM-julkaisutyyppi	A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Rahoitus

This research has received funding from the Academy of Finland (https://www.aka.fi/en/, decision Nos. 297893 and 318879 (ERA-NET NEURON Program)) and the European Union's Horizon 2020 Framework Programme for Research and Innovation (https://ec.europa.eu/programmes/horizon2020/en) under the Specific Grant Agreement Nos. 720270 (Human Brain Project SGA1), 785907 (Human Brain Project SGA2), and 945539 (Human Brain Project SGA3). The work was also supported by grants from Tampere University (Global pilot FARIA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The author wishes to thank Prof. Emerita Tuula O. Jalonen for introducing the astrocyte research field and Dr. Tiina Manninen for long-term dedicated collaboration in modeling neuronal and glial functions and testing various simulation tools. This research has received funding from the Academy of Finland ( https://www.aka.fi/en/ , decision Nos. 297893 and 318879 (ERA-NET NEURON Program)) and the European Union’s Horizon 2020 Framework Programme for Research and Innovation ( https://ec.europa.eu/programmes/horizon2020/en ) under the Specific Grant Agreement Nos. 720270 (Human Brain Project SGA1), 785907 (Human Brain Project SGA2), and 945539 (Human Brain Project SGA3). The work was also supported by grants from Tampere University (Global pilot FARIA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Rahoittajat	Rahoittajan numero
European Union's Horizon 2020 framework programme for research and innovation
European Union’s Horizon 2020 Framework Programme for Research and Innovation	785907, 720270, 945539
Academy of Finland	318879, 297893

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Yleinen neurotiede

Pääsy asiakirjaan

10.1016/j.conb.2023.102838

Siteeraa tätä

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title = "Computational modeling of neuron–glia signaling interactions to unravel cellular and neural circuit functioning",

abstract = "Glial cells have been shown to be vital for various brain functions, including homeostasis, information processing, and cognition. Over the past 30 years, various signaling interactions between neuronal and glial cells have been shown to underlie these functions. This review summarizes the interactions, particularly between neurons and astrocytes, which are types of glial cells. Some of the interactions remain controversial in part due to the nature of experimental methods and preparations used. Based on the accumulated data, computational models of the neuron–astrocyte interactions have been developed to explain the complex functions of astrocytes in neural circuits and to test conflicting hypotheses. This review presents the most significant recent models, modeling methods and simulation tools for neuron–astrocyte interactions. In the future, we will especially need more experimental research on awake animals in vivo and new computational models of neuron–glia interactions to advance our understanding of cellular dynamics and the functioning of neural circuits in different brain regions.",

keywords = "Astrocyte, Brain model, Glia, Large-scale neural network, Modeling, Neural circuit, Neuron–astrocyte interaction, Simulation, Tool development",

author = "Linne, \{Marja Leena\}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2024",

month = apr,

doi = "10.1016/j.conb.2023.102838",

language = "English",

volume = "85",

journal = "Current Opinion in Neurobiology",

issn = "0959-4388",

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TY - JOUR

T1 - Computational modeling of neuron–glia signaling interactions to unravel cellular and neural circuit functioning

AU - Linne, Marja Leena

PY - 2024/4

Y1 - 2024/4

N2 - Glial cells have been shown to be vital for various brain functions, including homeostasis, information processing, and cognition. Over the past 30 years, various signaling interactions between neuronal and glial cells have been shown to underlie these functions. This review summarizes the interactions, particularly between neurons and astrocytes, which are types of glial cells. Some of the interactions remain controversial in part due to the nature of experimental methods and preparations used. Based on the accumulated data, computational models of the neuron–astrocyte interactions have been developed to explain the complex functions of astrocytes in neural circuits and to test conflicting hypotheses. This review presents the most significant recent models, modeling methods and simulation tools for neuron–astrocyte interactions. In the future, we will especially need more experimental research on awake animals in vivo and new computational models of neuron–glia interactions to advance our understanding of cellular dynamics and the functioning of neural circuits in different brain regions.

AB - Glial cells have been shown to be vital for various brain functions, including homeostasis, information processing, and cognition. Over the past 30 years, various signaling interactions between neuronal and glial cells have been shown to underlie these functions. This review summarizes the interactions, particularly between neurons and astrocytes, which are types of glial cells. Some of the interactions remain controversial in part due to the nature of experimental methods and preparations used. Based on the accumulated data, computational models of the neuron–astrocyte interactions have been developed to explain the complex functions of astrocytes in neural circuits and to test conflicting hypotheses. This review presents the most significant recent models, modeling methods and simulation tools for neuron–astrocyte interactions. In the future, we will especially need more experimental research on awake animals in vivo and new computational models of neuron–glia interactions to advance our understanding of cellular dynamics and the functioning of neural circuits in different brain regions.

KW - Astrocyte

KW - Brain model

KW - Glia

KW - Large-scale neural network

KW - Modeling

KW - Neural circuit

KW - Neuron–astrocyte interaction

KW - Simulation

KW - Tool development

U2 - 10.1016/j.conb.2023.102838

DO - 10.1016/j.conb.2023.102838

M3 - Review Article

AN - SCOPUS:85183951962

SN - 0959-4388

VL - 85

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

M1 - 102838

ER -

Computational modeling of neuron–glia signaling interactions to unravel cellular and neural circuit functioning

Abstrakti

Rahoitus

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

Siteeraa tätä