Developmental and Nutritional Changes in Children with Severe Acute Malnutrition Provided with n-3 Fatty Acids Improved Ready-to-Use Therapeutic Food and Psychosocial Support: A Pilot Study in Tanzania

Fredrick Cyprian Mwita; George PrayGod; Erica Sanga; Theresia Setebe; Gaudensia Joseph; Happyness Kunzi; Jayne Webster; Melissa Gladstone; Rebecca Searle; Maimuna Ahmed; Adolfine Hokororo; Suzanne Filteau; Henrik Friis; André Briend; Mette Frahm Olsen

doi:10.3390/nu16050692

Developmental and Nutritional Changes in Children with Severe Acute Malnutrition Provided with n-3 Fatty Acids Improved Ready-to-Use Therapeutic Food and Psychosocial Support: A Pilot Study in Tanzania

Fredrick Cyprian Mwita
, George PrayGod^*
, Erica Sanga
, Theresia Setebe
, Gaudensia Joseph
, Happyness Kunzi
, Jayne Webster
, Melissa Gladstone
, Rebecca Searle
, Maimuna Ahmed
, Adolfine Hokororo
, Suzanne Filteau
, Henrik Friis
, André Briend
, Mette Frahm Olsen

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

3 Sitaatiot (Scopus)

11 Lataukset (Pure)

Abstrakti

Children with severe acute malnutrition (SAM) are at high risk of impaired development. Contributing causes include the inadequate intake of specific nutrients such as polyunsaturated fatty acids (PUFAs) and a lack of adequate stimulation. We conducted a pilot study assessing developmental and nutritional changes in children with SAM provided with a modified ready-to-use therapeutic food and context-specific psychosocial intervention in Mwanza, Tanzania. We recruited 82 children with SAM (6–36 months) and 88 sex- and age-matched non-malnourished children. We measured child development, using the Malawi Development Assessment Tool (MDAT), measures of family and maternal care for children, and whole-blood PUFA levels. At baseline, the mean total MDAT z-score of children with SAM was lower than non-malnourished children; −2.37 (95% confidence interval: −2.92; −1.82), as were their total n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels. After 8 weeks of intervention, MDAT z-scores improved in all domains, especially fine motor, among children with SAM. Total n-3 and EPA levels increased, total n-6 fatty acids decreased, and DHA remained unchanged. Family and maternal care also improved. The suggested benefits of the combined interventions on the developmental and nutritional status of children with SAM will be tested in a future trial.

Alkuperäiskieli	Englanti
Artikkeli	692
Sivumäärä	14
Julkaisu	Nutrients
Vuosikerta	16
Numero	5
DOI - pysyväislinkit	https://doi.org/10.3390/nu16050692
Tila	Julkaistu - maalisk. 2024
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

This research was funded by the Department of Health and Social Care (DHSC), the Foreign, Commonwealth & Development Office (FCDO), the Medical Research Council (MRC) and Wellcome Grant reference: MR/T003731/1 and F.C.M. was supported by a fellowship funded by the National Institute for Health Research (NIHR) (CSA2020E-3135) using UK Aid from the UK Government to support global health research, as part of the EDCTP2 Programme supported by the European Union, and the UK Medical Research Council (MRC), grant reference: MR/T003731/1.

Rahoittajat	Rahoittajan numero
Department of Health and Social Care Systems
Medical Research Council
UK Foreign, Commonwealth and Development office
European Commission
UK Foreign, Commonwealth and Development office
Wellcome Trust	MR/T003731/1
National Institute for Health and Care Research	CSA2020E-3135

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 2 – Ei nälkää

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

Pääsy asiakirjaan

10.3390/nu16050692Lisenssi: CC BY

nutrients-16-00692-v2Final published version, 264 KBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202404103425Lisenssi: CC BY

Sormenjälki

Sukella tutkimusaiheisiin 'Developmental and Nutritional Changes in Children with Severe Acute Malnutrition Provided with n-3 Fatty Acids Improved Ready-to-Use Therapeutic Food and Psychosocial Support: A Pilot Study in Tanzania'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.

Siteeraa tätä

Mwita, F. C., PrayGod, G., Sanga, E., Setebe, T., Joseph, G., Kunzi, H., Webster, J., Gladstone, M., Searle, R., Ahmed, M., Hokororo, A., Filteau, S., Friis, H., Briend, A., & Olsen, M. F. (2024). Developmental and Nutritional Changes in Children with Severe Acute Malnutrition Provided with n-3 Fatty Acids Improved Ready-to-Use Therapeutic Food and Psychosocial Support: A Pilot Study in Tanzania. Nutrients, 16(5), Artikkeli 692. https://doi.org/10.3390/nu16050692

@article{1064a38a62a049e1a2898efd6eb84cc2,

title = "Developmental and Nutritional Changes in Children with Severe Acute Malnutrition Provided with n-3 Fatty Acids Improved Ready-to-Use Therapeutic Food and Psychosocial Support: A Pilot Study in Tanzania",

abstract = "Children with severe acute malnutrition (SAM) are at high risk of impaired development. Contributing causes include the inadequate intake of specific nutrients such as polyunsaturated fatty acids (PUFAs) and a lack of adequate stimulation. We conducted a pilot study assessing developmental and nutritional changes in children with SAM provided with a modified ready-to-use therapeutic food and context-specific psychosocial intervention in Mwanza, Tanzania. We recruited 82 children with SAM (6–36 months) and 88 sex- and age-matched non-malnourished children. We measured child development, using the Malawi Development Assessment Tool (MDAT), measures of family and maternal care for children, and whole-blood PUFA levels. At baseline, the mean total MDAT z-score of children with SAM was lower than non-malnourished children; −2.37 (95\% confidence interval: −2.92; −1.82), as were their total n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels. After 8 weeks of intervention, MDAT z-scores improved in all domains, especially fine motor, among children with SAM. Total n-3 and EPA levels increased, total n-6 fatty acids decreased, and DHA remained unchanged. Family and maternal care also improved. The suggested benefits of the combined interventions on the developmental and nutritional status of children with SAM will be tested in a future trial.",

keywords = "child development, fatty acids, psychosocial stimulation, ready-to-use therapeutic foods, severe acute malnutrition",

author = "Mwita, \{Fredrick Cyprian\} and George PrayGod and Erica Sanga and Theresia Setebe and Gaudensia Joseph and Happyness Kunzi and Jayne Webster and Melissa Gladstone and Rebecca Searle and Maimuna Ahmed and Adolfine Hokororo and Suzanne Filteau and Henrik Friis and Andr{\'e} Briend and Olsen, \{Mette Frahm\}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = mar,

doi = "10.3390/nu16050692",

language = "English",

volume = "16",

journal = "Nutrients",

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Mwita, FC, PrayGod, G, Sanga, E, Setebe, T, Joseph, G, Kunzi, H, Webster, J, Gladstone, M, Searle, R, Ahmed, M, Hokororo, A, Filteau, S, Friis, H, Briend, A & Olsen, MF 2024, 'Developmental and Nutritional Changes in Children with Severe Acute Malnutrition Provided with n-3 Fatty Acids Improved Ready-to-Use Therapeutic Food and Psychosocial Support: A Pilot Study in Tanzania', Nutrients, Vuosikerta 16, Nro 5, 692. https://doi.org/10.3390/nu16050692

Developmental and Nutritional Changes in Children with Severe Acute Malnutrition Provided with n-3 Fatty Acids Improved Ready-to-Use Therapeutic Food and Psychosocial Support: A Pilot Study in Tanzania. / Mwita, Fredrick Cyprian; PrayGod, George; Sanga, Erica et al.
julkaisussa: Nutrients, Vuosikerta 16, Nro 5, 692, 03.2024.

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

TY - JOUR

T1 - Developmental and Nutritional Changes in Children with Severe Acute Malnutrition Provided with n-3 Fatty Acids Improved Ready-to-Use Therapeutic Food and Psychosocial Support

T2 - A Pilot Study in Tanzania

AU - Mwita, Fredrick Cyprian

AU - PrayGod, George

AU - Sanga, Erica

AU - Setebe, Theresia

AU - Joseph, Gaudensia

AU - Kunzi, Happyness

AU - Webster, Jayne

AU - Gladstone, Melissa

AU - Searle, Rebecca

AU - Ahmed, Maimuna

AU - Hokororo, Adolfine

AU - Filteau, Suzanne

AU - Friis, Henrik

AU - Briend, André

AU - Olsen, Mette Frahm

PY - 2024/3

Y1 - 2024/3

N2 - Children with severe acute malnutrition (SAM) are at high risk of impaired development. Contributing causes include the inadequate intake of specific nutrients such as polyunsaturated fatty acids (PUFAs) and a lack of adequate stimulation. We conducted a pilot study assessing developmental and nutritional changes in children with SAM provided with a modified ready-to-use therapeutic food and context-specific psychosocial intervention in Mwanza, Tanzania. We recruited 82 children with SAM (6–36 months) and 88 sex- and age-matched non-malnourished children. We measured child development, using the Malawi Development Assessment Tool (MDAT), measures of family and maternal care for children, and whole-blood PUFA levels. At baseline, the mean total MDAT z-score of children with SAM was lower than non-malnourished children; −2.37 (95% confidence interval: −2.92; −1.82), as were their total n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels. After 8 weeks of intervention, MDAT z-scores improved in all domains, especially fine motor, among children with SAM. Total n-3 and EPA levels increased, total n-6 fatty acids decreased, and DHA remained unchanged. Family and maternal care also improved. The suggested benefits of the combined interventions on the developmental and nutritional status of children with SAM will be tested in a future trial.

AB - Children with severe acute malnutrition (SAM) are at high risk of impaired development. Contributing causes include the inadequate intake of specific nutrients such as polyunsaturated fatty acids (PUFAs) and a lack of adequate stimulation. We conducted a pilot study assessing developmental and nutritional changes in children with SAM provided with a modified ready-to-use therapeutic food and context-specific psychosocial intervention in Mwanza, Tanzania. We recruited 82 children with SAM (6–36 months) and 88 sex- and age-matched non-malnourished children. We measured child development, using the Malawi Development Assessment Tool (MDAT), measures of family and maternal care for children, and whole-blood PUFA levels. At baseline, the mean total MDAT z-score of children with SAM was lower than non-malnourished children; −2.37 (95% confidence interval: −2.92; −1.82), as were their total n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels. After 8 weeks of intervention, MDAT z-scores improved in all domains, especially fine motor, among children with SAM. Total n-3 and EPA levels increased, total n-6 fatty acids decreased, and DHA remained unchanged. Family and maternal care also improved. The suggested benefits of the combined interventions on the developmental and nutritional status of children with SAM will be tested in a future trial.

KW - child development

KW - fatty acids

KW - psychosocial stimulation

KW - ready-to-use therapeutic foods

KW - severe acute malnutrition

U2 - 10.3390/nu16050692

DO - 10.3390/nu16050692

M3 - Article

C2 - 38474820

AN - SCOPUS:85187428713

SN - 2072-6643

VL - 16

JO - Nutrients

JF - Nutrients

IS - 5

M1 - 692

ER -