Direct Contraction Force Measurements of Engineered Cardiac Tissue Constructs With Inotropic Drug Exposure

Maria Koivisto, Milad Mosallaei, Tarja Toimela, Sampo Tuukkanen, Tuula Heinonen

    Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

    7 Lataukset (Pure)

    Abstrakti

    Contractility is one of the most crucial functions of the heart because it is directly related to the maintenance of blood perfusion throughout the body. Both increase and decrease in contractility may cause fatal consequences. Therefore, drug discovery would benefit greatly from reliable testing of candidate molecule effects on contractility capacity. In this study, we further developed a dual-axis piezoelectric force sensor together with our human cell–based vascularized cardiac tissue constructs for cardiac contraction force measurements. The capability to detect drug-induced inotropic effects was tested with a set of known positive and negative inotropic compounds of isoprenaline, milrinone, omecamtiv mecarbil, propranolol, or verapamil in different concentrations. Both positive and negative inotropic effects were measurable, showing that our cardiac contraction force measurement system including a piezoelectric cantilever sensor and a human cell–based cardiac tissue constructs has the potential to be used for testing of inotropic drug effects.
    AlkuperäiskieliEnglanti
    Artikkeli871569
    Sivumäärä9
    JulkaisuFRONTIERS IN PHARMACOLOGY
    Vuosikerta13
    DOI - pysyväislinkit
    TilaJulkaistu - 3 toukok. 2022
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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