Diseases with oral manifestations among adult asthmatics in Finland: A population-based matched cohort study

Riikka Lemmetyinen; Jussi Karjalainen; Anna But; Risto Renkonen; Juha Pekkanen; Jari Haukka; Sanna Toppila-Salmi

doi:10.1136/bmjopen-2021-053133

Diseases with oral manifestations among adult asthmatics in Finland: A population-based matched cohort study

Riikka Lemmetyinen^*
, Jussi Karjalainen
, Anna But
, Risto Renkonen
, Juha Pekkanen
, Jari Haukka
, Sanna Toppila-Salmi

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

8 Sitaatiot (Scopus)

20 Lataukset (Pure)

Abstrakti

Objectives Many comorbidities are associated with adult asthma and may exacerbate the asthma burden of disease. This study aims to investigate the risk for major oral diseases or oral-manifesting diseases in asthmatic compared with non-asthmatic adults. Design We conducted a population-based matched cohort study with a 13.8-year follow-up. Setting A baseline questionnaire was completed by participants in 1997 and follow-up data were extracted from the national hospital discharge registry of the National Institute for Health and Welfare in Finland from 1997 to 2014. Participants A total of 1394 adults with asthma were matched with 2398 adults without asthma based on sex, age and area of residence. Asthmatic adults were identified from the Drug Reimbursement Register of the Finnish Social Insurance Institution based on a special drug reimbursement right resulting from asthma. Participants without asthma were identified from the Population Register. Main outcomes and measures Oral health-related primary diagnoses were retrieved using codes from the International Classification of Diseases, 10th edition and divided into groups of diseases. Cox's proportional hazards models stratified by matching unit and models matched and adjusted for pack-years, education level and body mass index (when possible) were used to evaluate the matched and further adjusted HRs for diseases comparing asthmatic and non-asthmatic cohorts. Results Adult asthma was associated with a higher risk for any oral-manifesting disease (adjusted HR 1.41, 95% CI 1.11 to 1.80), herpes zoster (adjusted HR 6.18, 95% CI 1.21 to 31.6), benign tumours of the oral cavity and pharynx (matched HR 1.94, 95% CI 1.05 to 3.56) and dermatological diseases (pemphigus, pemphigoid, dermatitis herpetiformis, psoriasis and lichen planus, HR 1.67, 95% CI 1.01 to 2.78). Conclusions In this study, adult asthmatics experienced a higher risk for a major oral disease or oral-manifesting disease.

Alkuperäiskieli	Englanti
Artikkeli	e053133
Julkaisu	BMJ Open
Vuosikerta	11
Numero	12
DOI - pysyväislinkit	https://doi.org/10.1136/bmjopen-2021-053133
Tila	Julkaistu - 31 jouluk. 2021
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

Contributors RL, ST-S, JK and JH contributed to data acquisition, analysis, interpretation and design, and revised the manuscript for critical intellectual content. AB, RR and JP critically revised the manuscript. All authors agree to be accountable for all aspects of the work. RL is the guarantor of this manuscript. Funding This study was supported by grants from the Finnish Allergy Research Foundation, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, the Finnish Medical Foundation, the Finnish Society of Allergology and Immunology, the Foundation of the Finnish Anti-Tuberculosis Association, the Jane and Aatos Erkko Foundation, the Paulo Foundation, the Research Foundation of Pulmonary Diseases, the Tampere Tuberculosis Foundation, the Väinö and Laina Kivi Foundation, the Yrjö Jahnsson Foundation and Rehabilitation Funds of the Finnish Social Insurance Institution. This study was supported by grants from the Finnish Allergy Research Foundation, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, the Finnish Medical Foundation, the Finnish Society of Allergology and Immunology, the Foundation of the Finnish Anti-Tuberculosis Association, the Jane and Aatos Erkko Foundation, the Paulo Foundation, the Research Foundation of Pulmonary Diseases, the Tampere Tuberculosis Foundation, the V?in? and Laina Kivi Foundation, the Yrj? Jahnsson Foundation and Rehabilitation Funds of the Finnish Social Insurance Institution.

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 3 – Hyvä terveys ja hyvinvointi

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Yleinen lääketiede

Pääsy asiakirjaan

10.1136/bmjopen-2021-053133Lisenssi: CC BY-NC

e053133.full-1Final published version, 392 KBLisenssi: CC BY-NC

https://urn.fi/URN:NBN:fi:tuni-202201241572Lisenssi: CC BY-NC

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@article{99d3e09c25a74de5bcb5b07ab959f882,

title = "Diseases with oral manifestations among adult asthmatics in Finland: A population-based matched cohort study",

abstract = "Objectives Many comorbidities are associated with adult asthma and may exacerbate the asthma burden of disease. This study aims to investigate the risk for major oral diseases or oral-manifesting diseases in asthmatic compared with non-asthmatic adults. Design We conducted a population-based matched cohort study with a 13.8-year follow-up. Setting A baseline questionnaire was completed by participants in 1997 and follow-up data were extracted from the national hospital discharge registry of the National Institute for Health and Welfare in Finland from 1997 to 2014. Participants A total of 1394 adults with asthma were matched with 2398 adults without asthma based on sex, age and area of residence. Asthmatic adults were identified from the Drug Reimbursement Register of the Finnish Social Insurance Institution based on a special drug reimbursement right resulting from asthma. Participants without asthma were identified from the Population Register. Main outcomes and measures Oral health-related primary diagnoses were retrieved using codes from the International Classification of Diseases, 10th edition and divided into groups of diseases. Cox's proportional hazards models stratified by matching unit and models matched and adjusted for pack-years, education level and body mass index (when possible) were used to evaluate the matched and further adjusted HRs for diseases comparing asthmatic and non-asthmatic cohorts. Results Adult asthma was associated with a higher risk for any oral-manifesting disease (adjusted HR 1.41, 95\% CI 1.11 to 1.80), herpes zoster (adjusted HR 6.18, 95\% CI 1.21 to 31.6), benign tumours of the oral cavity and pharynx (matched HR 1.94, 95\% CI 1.05 to 3.56) and dermatological diseases (pemphigus, pemphigoid, dermatitis herpetiformis, psoriasis and lichen planus, HR 1.67, 95\% CI 1.01 to 2.78). Conclusions In this study, adult asthmatics experienced a higher risk for a major oral disease or oral-manifesting disease. ",

keywords = "Asthma, EPIDEMIOLOGY, ORAL MEDICINE, PUBLIC HEALTH",

author = "Riikka Lemmetyinen and Jussi Karjalainen and Anna But and Risto Renkonen and Juha Pekkanen and Jari Haukka and Sanna Toppila-Salmi",

note = "Funding Information: Contributors RL, ST-S, JK and JH contributed to data acquisition, analysis, interpretation and design, and revised the manuscript for critical intellectual content. AB, RR and JP critically revised the manuscript. All authors agree to be accountable for all aspects of the work. RL is the guarantor of this manuscript. Funding This study was supported by grants from the Finnish Allergy Research Foundation, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, the Finnish Medical Foundation, the Finnish Society of Allergology and Immunology, the Foundation of the Finnish Anti-Tuberculosis Association, the Jane and Aatos Erkko Foundation, the Paulo Foundation, the Research Foundation of Pulmonary Diseases, the Tampere Tuberculosis Foundation, the V{\"a}in{\"o} and Laina Kivi Foundation, the Yrj{\"o} Jahnsson Foundation and Rehabilitation Funds of the Finnish Social Insurance Institution. Funding Information: This study was supported by grants from the Finnish Allergy Research Foundation, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, the Finnish Medical Foundation, the Finnish Society of Allergology and Immunology, the Foundation of the Finnish Anti-Tuberculosis Association, the Jane and Aatos Erkko Foundation, the Paulo Foundation, the Research Foundation of Pulmonary Diseases, the Tampere Tuberculosis Foundation, the V{\"a}in{\"o} and Laina Kivi Foundation, the Yrj{\"o} Jahnsson Foundation and Rehabilitation Funds of the Finnish Social Insurance Institution.",

year = "2021",

month = dec,

day = "31",

doi = "10.1136/bmjopen-2021-053133",

language = "English",

volume = "11",

journal = "BMJ Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

number = "12",

}

TY - JOUR

T1 - Diseases with oral manifestations among adult asthmatics in Finland

T2 - A population-based matched cohort study

AU - Lemmetyinen, Riikka

AU - Karjalainen, Jussi

AU - But, Anna

AU - Renkonen, Risto

AU - Pekkanen, Juha

AU - Haukka, Jari

AU - Toppila-Salmi, Sanna

N1 - Funding Information: Contributors RL, ST-S, JK and JH contributed to data acquisition, analysis, interpretation and design, and revised the manuscript for critical intellectual content. AB, RR and JP critically revised the manuscript. All authors agree to be accountable for all aspects of the work. RL is the guarantor of this manuscript. Funding This study was supported by grants from the Finnish Allergy Research Foundation, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, the Finnish Medical Foundation, the Finnish Society of Allergology and Immunology, the Foundation of the Finnish Anti-Tuberculosis Association, the Jane and Aatos Erkko Foundation, the Paulo Foundation, the Research Foundation of Pulmonary Diseases, the Tampere Tuberculosis Foundation, the Väinö and Laina Kivi Foundation, the Yrjö Jahnsson Foundation and Rehabilitation Funds of the Finnish Social Insurance Institution. Funding Information: This study was supported by grants from the Finnish Allergy Research Foundation, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, the Finnish Medical Foundation, the Finnish Society of Allergology and Immunology, the Foundation of the Finnish Anti-Tuberculosis Association, the Jane and Aatos Erkko Foundation, the Paulo Foundation, the Research Foundation of Pulmonary Diseases, the Tampere Tuberculosis Foundation, the Väinö and Laina Kivi Foundation, the Yrjö Jahnsson Foundation and Rehabilitation Funds of the Finnish Social Insurance Institution.

PY - 2021/12/31

Y1 - 2021/12/31

N2 - Objectives Many comorbidities are associated with adult asthma and may exacerbate the asthma burden of disease. This study aims to investigate the risk for major oral diseases or oral-manifesting diseases in asthmatic compared with non-asthmatic adults. Design We conducted a population-based matched cohort study with a 13.8-year follow-up. Setting A baseline questionnaire was completed by participants in 1997 and follow-up data were extracted from the national hospital discharge registry of the National Institute for Health and Welfare in Finland from 1997 to 2014. Participants A total of 1394 adults with asthma were matched with 2398 adults without asthma based on sex, age and area of residence. Asthmatic adults were identified from the Drug Reimbursement Register of the Finnish Social Insurance Institution based on a special drug reimbursement right resulting from asthma. Participants without asthma were identified from the Population Register. Main outcomes and measures Oral health-related primary diagnoses were retrieved using codes from the International Classification of Diseases, 10th edition and divided into groups of diseases. Cox's proportional hazards models stratified by matching unit and models matched and adjusted for pack-years, education level and body mass index (when possible) were used to evaluate the matched and further adjusted HRs for diseases comparing asthmatic and non-asthmatic cohorts. Results Adult asthma was associated with a higher risk for any oral-manifesting disease (adjusted HR 1.41, 95% CI 1.11 to 1.80), herpes zoster (adjusted HR 6.18, 95% CI 1.21 to 31.6), benign tumours of the oral cavity and pharynx (matched HR 1.94, 95% CI 1.05 to 3.56) and dermatological diseases (pemphigus, pemphigoid, dermatitis herpetiformis, psoriasis and lichen planus, HR 1.67, 95% CI 1.01 to 2.78). Conclusions In this study, adult asthmatics experienced a higher risk for a major oral disease or oral-manifesting disease.

AB - Objectives Many comorbidities are associated with adult asthma and may exacerbate the asthma burden of disease. This study aims to investigate the risk for major oral diseases or oral-manifesting diseases in asthmatic compared with non-asthmatic adults. Design We conducted a population-based matched cohort study with a 13.8-year follow-up. Setting A baseline questionnaire was completed by participants in 1997 and follow-up data were extracted from the national hospital discharge registry of the National Institute for Health and Welfare in Finland from 1997 to 2014. Participants A total of 1394 adults with asthma were matched with 2398 adults without asthma based on sex, age and area of residence. Asthmatic adults were identified from the Drug Reimbursement Register of the Finnish Social Insurance Institution based on a special drug reimbursement right resulting from asthma. Participants without asthma were identified from the Population Register. Main outcomes and measures Oral health-related primary diagnoses were retrieved using codes from the International Classification of Diseases, 10th edition and divided into groups of diseases. Cox's proportional hazards models stratified by matching unit and models matched and adjusted for pack-years, education level and body mass index (when possible) were used to evaluate the matched and further adjusted HRs for diseases comparing asthmatic and non-asthmatic cohorts. Results Adult asthma was associated with a higher risk for any oral-manifesting disease (adjusted HR 1.41, 95% CI 1.11 to 1.80), herpes zoster (adjusted HR 6.18, 95% CI 1.21 to 31.6), benign tumours of the oral cavity and pharynx (matched HR 1.94, 95% CI 1.05 to 3.56) and dermatological diseases (pemphigus, pemphigoid, dermatitis herpetiformis, psoriasis and lichen planus, HR 1.67, 95% CI 1.01 to 2.78). Conclusions In this study, adult asthmatics experienced a higher risk for a major oral disease or oral-manifesting disease.

KW - Asthma

KW - EPIDEMIOLOGY

KW - ORAL MEDICINE

KW - PUBLIC HEALTH

U2 - 10.1136/bmjopen-2021-053133

DO - 10.1136/bmjopen-2021-053133

M3 - Article

AN - SCOPUS:85122629782

SN - 2044-6055

VL - 11

JO - BMJ Open

JF - BMJ Open

IS - 12

M1 - e053133

ER -

Diseases with oral manifestations among adult asthmatics in Finland: A population-based matched cohort study

Abstrakti

Rahoitus

YK:n kestävän kehityksen tavoitteet

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

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