Ecological diversity profiles of non-vaccine-targeted HPVs after gender-based community vaccination efforts

Ville N. Pimenoff; Penelope Gray; Karolina Louvanto; Tiina Eriksson; Camilla Lagheden; Anna Söderlund-Strand; Joakim Dillner; Matti Lehtinen

doi:10.1016/j.chom.2023.10.001

Ecological diversity profiles of non-vaccine-targeted HPVs after gender-based community vaccination efforts

Ville N. Pimenoff^*
, Penelope Gray
, Karolina Louvanto
, Tiina Eriksson
, Camilla Lagheden
, Anna Söderlund-Strand
, Joakim Dillner
, Matti Lehtinen

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

35 Sitaatiot (Scopus)

13 Lataukset (Pure)

Abstrakti

The long-term effect of population-level human papillomavirus (HPV) vaccination on the viral ecology of the untargeted HPVs is poorly understood. We performed an 8-year follow-up of 33 communities randomized to gender-neutral HPV16/18 vaccination, girls-only HPV16/18 vaccination, and control communities without HPV vaccination. The 1992/93 and 1994 birth cohorts were invited in school years 2007/8 and 2008/9. Follow-up cervico-vaginal sampling at 18 and 22 years of age, 4 and 8 years post-vaccination, respectively, were attended by 11,396 and 5,602 participants. HPV types 6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68 were genotyped and used for the community-level ecological diversity estimations. Gender-neutral vaccination communities with a stronger herd immunity than girls-only vaccination communities show a significantly increased HPV α-diversity (p = 1.1 × 10⁻⁸) from 4 to 8 years post-vaccination, despite the clearance of the vaccine-targeted HPVs in these communities. This likely sign of niche occupation by the non-vaccine-targeted HPVs will potentially affect the future cervical cancer screening programs but should not interfere with the WHO mission to eliminate cervical cancer.

Alkuperäiskieli	Englanti
Sivut	1921-1929.e3
Sivumäärä	9
Julkaisu	Cell Host and Microbe
Vuosikerta	31
Numero	11
DOI - pysyväislinkit	https://doi.org/10.1016/j.chom.2023.10.001
Tila	Julkaistu - 8 marrask. 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

The authors wish to thank the 85 study nurses without whom the initial enrollment and follow-up of the community-randomized Finnish HPV vaccination trial would not have been possible. The authors also acknowledge the brilliant artwork collaboration with Andre Demony for Video S1 and Pekka Saari (Huumos OSK, Finland) for Video S2 illustration. This work was supported by the European Union's Horizon 2020 research and innovation program under grant agreement no. 874662 (HEAP) and no. 847845 (RISCC) as well as the Cities Partnership Program Funds and Karolinska Institutet Funds to V.N.P. Conceptualization, V.N.P. and M.L.; methodology, software, and analysis, V.N.P.; resources, V.N.P. K.L. J.D. and M.L.; sample processing, T.E. P.G. C.L. and A.S.-S.; writing – original draft, V.N.P. and M.L.; writing – review & editing, V.N.P. P.G. K.L. C.L. A.S.-S. J.D. and M.L.; funding acquisition, V.N.P. M.L. and J.D.; visualization, V.N.P. V.N.P. is also affiliated to Aqsens Health Ltd but not related to this work.

Rahoittajat	Rahoittajan numero
Karolinska Institutet
Horizon 2020, EU	874662, 847845

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 3 – Hyvä terveys ja hyvinvointi

Julkaisufoorumi-taso

Jufo-taso 3

!!ASJC Scopus subject areas

Parasitology
Microbiology
Virology

Pääsy asiakirjaan

10.1016/j.chom.2023.10.001Lisenssi: CC BY

1-s2.0-S1931312823003992-mainFinal published version, 1,7 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202311149640Lisenssi: CC BY

Siteeraa tätä

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title = "Ecological diversity profiles of non-vaccine-targeted HPVs after gender-based community vaccination efforts",

abstract = "The long-term effect of population-level human papillomavirus (HPV) vaccination on the viral ecology of the untargeted HPVs is poorly understood. We performed an 8-year follow-up of 33 communities randomized to gender-neutral HPV16/18 vaccination, girls-only HPV16/18 vaccination, and control communities without HPV vaccination. The 1992/93 and 1994 birth cohorts were invited in school years 2007/8 and 2008/9. Follow-up cervico-vaginal sampling at 18 and 22 years of age, 4 and 8 years post-vaccination, respectively, were attended by 11,396 and 5,602 participants. HPV types 6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68 were genotyped and used for the community-level ecological diversity estimations. Gender-neutral vaccination communities with a stronger herd immunity than girls-only vaccination communities show a significantly increased HPV α-diversity (p = 1.1 × 10−8) from 4 to 8 years post-vaccination, despite the clearance of the vaccine-targeted HPVs in these communities. This likely sign of niche occupation by the non-vaccine-targeted HPVs will potentially affect the future cervical cancer screening programs but should not interfere with the WHO mission to eliminate cervical cancer.",

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author = "Pimenoff, \{Ville N.\} and Penelope Gray and Karolina Louvanto and Tiina Eriksson and Camilla Lagheden and Anna S{\"o}derlund-Strand and Joakim Dillner and Matti Lehtinen",

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doi = "10.1016/j.chom.2023.10.001",

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TY - JOUR

T1 - Ecological diversity profiles of non-vaccine-targeted HPVs after gender-based community vaccination efforts

AU - Pimenoff, Ville N.

AU - Gray, Penelope

AU - Louvanto, Karolina

AU - Eriksson, Tiina

AU - Lagheden, Camilla

AU - Söderlund-Strand, Anna

AU - Dillner, Joakim

AU - Lehtinen, Matti

PY - 2023/11/8

Y1 - 2023/11/8

N2 - The long-term effect of population-level human papillomavirus (HPV) vaccination on the viral ecology of the untargeted HPVs is poorly understood. We performed an 8-year follow-up of 33 communities randomized to gender-neutral HPV16/18 vaccination, girls-only HPV16/18 vaccination, and control communities without HPV vaccination. The 1992/93 and 1994 birth cohorts were invited in school years 2007/8 and 2008/9. Follow-up cervico-vaginal sampling at 18 and 22 years of age, 4 and 8 years post-vaccination, respectively, were attended by 11,396 and 5,602 participants. HPV types 6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68 were genotyped and used for the community-level ecological diversity estimations. Gender-neutral vaccination communities with a stronger herd immunity than girls-only vaccination communities show a significantly increased HPV α-diversity (p = 1.1 × 10−8) from 4 to 8 years post-vaccination, despite the clearance of the vaccine-targeted HPVs in these communities. This likely sign of niche occupation by the non-vaccine-targeted HPVs will potentially affect the future cervical cancer screening programs but should not interfere with the WHO mission to eliminate cervical cancer.

AB - The long-term effect of population-level human papillomavirus (HPV) vaccination on the viral ecology of the untargeted HPVs is poorly understood. We performed an 8-year follow-up of 33 communities randomized to gender-neutral HPV16/18 vaccination, girls-only HPV16/18 vaccination, and control communities without HPV vaccination. The 1992/93 and 1994 birth cohorts were invited in school years 2007/8 and 2008/9. Follow-up cervico-vaginal sampling at 18 and 22 years of age, 4 and 8 years post-vaccination, respectively, were attended by 11,396 and 5,602 participants. HPV types 6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68 were genotyped and used for the community-level ecological diversity estimations. Gender-neutral vaccination communities with a stronger herd immunity than girls-only vaccination communities show a significantly increased HPV α-diversity (p = 1.1 × 10−8) from 4 to 8 years post-vaccination, despite the clearance of the vaccine-targeted HPVs in these communities. This likely sign of niche occupation by the non-vaccine-targeted HPVs will potentially affect the future cervical cancer screening programs but should not interfere with the WHO mission to eliminate cervical cancer.

KW - community randomization

KW - elimination

KW - gender-based vaccination strategy

KW - human papillomavirus

KW - longitudinal follow-up study

KW - niche occupation

KW - type replacement

KW - viral ecology

U2 - 10.1016/j.chom.2023.10.001

DO - 10.1016/j.chom.2023.10.001

M3 - Article

AN - SCOPUS:85175432401

SN - 1931-3128

VL - 31

SP - 1921-1929.e3

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 11

ER -

Ecological diversity profiles of non-vaccine-targeted HPVs after gender-based community vaccination efforts

Abstrakti

Rahoitus

YK:n kestävän kehityksen tavoitteet

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

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