En Route to New Bioactive Compounds from Natural Feedstock: Protection and Reduction of Quinic Acid

Suvi Holmstedt, Nuno Rafael Candeias, Alisa Koivuporras

    Tutkimustuotos: PosteriTieteellinen

    50 Lataukset (Pure)

    Abstrakti

    The use of biomass-derived compounds allows to utilize cheap chiral molecules as starting materials and create potential drug precursors, among other uses.1-2 This study is based on quinic acid 1, a natural chiral polyol, which is a cheap material and synthetically attractive due to its multiple functional groups.3-4 Quinic acid was transformed into its corresponding lactone and different protecting groups using the tridimensional arrangement of the vicinal diol framework were explored, allowing the preparation of seven different lactone derivatives. Reduction of the lactone exposes a primary hydroxyl functionality that can be further explored due to its higher reactivity. By functionalization/defunctionalization of those hydroxyl groups, a library of different quinic acid derivatives was synthesized and is currently being tested against HT29 human colorectal adenocarcinoma cells.
    AlkuperäiskieliEnglanti
    TilaJulkaistu - 5 syysk. 2018
    OKM-julkaisutyyppiEi OKM-tyyppiä
    TapahtumaEurasia Conference on Chemical Sciences - Rome, Italia
    Kesto: 5 syysk. 20188 syysk. 2018
    http://www.eurasia2018.org/rome/

    Conference

    ConferenceEurasia Conference on Chemical Sciences
    Maa/AlueItalia
    KaupunkiRome
    Ajanjakso5/09/188/09/18
    www-osoite

    Sormenjälki

    Sukella tutkimusaiheisiin 'En Route to New Bioactive Compounds from Natural Feedstock: Protection and Reduction of Quinic Acid'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.

    Siteeraa tätä