@article{e79146b4189c41a195cf7f3515f6878c,
title = "Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient",
abstract = "Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system where the main pathogenetic events include demyelination and axonal degeneration. Here, we generated a human induced pluripotent stem cell (hiPSC) line from peripheral blood mononuclear cells of an MS patient utilizing Sendai virus reprogramming. The produced hiPSC line expressed pluripotency markers, differentiated into three germ layers, showed a normal karyotype and was free of virus vectors, transgenes and mycoplasma. Established hiPSCs are a valuable source for studies of MS disease modeling and drug discovery.",
author = "Johanna Lotila and Tanja Hyv{\"a}rinen and Heli Skottman and Laura Airas and Susanna Narkilahti and Sanna Hagman",
note = "Funding Information: This work was supported by Academy of Finland (SH 330707; 335937, SN 336665), Neurocenter Finland government funding (LA, SH, SN), The Finnish MS Foundation (SH, JL), the P{\"a}ivikki ja Sakari Sohlberg Foundation (SH), the Finnish Cultural Foundation (SH) and the Doctoral Programme in Medicine, Biosciences and Biomedical Engineering, Tampere University (JL). The authors acknowledge the BioMediTech Virus Production Facility of Tampere University, Tampere Facility of Flow Cytometry, the Biocenter Finland (BF) and Tampere Imaging Facility (TIF) for their service. Moreover, the authors acknowledge Fimlab Laboratoriot Oy, Tampere, Finland, and the Institute for Molecular Medicine Finland FIMM Technology Centre, University of Helsinki, Finland, for their service. We thank Eija Hannuksela for her technical assistance with hiPSC line production, cell maintenance and analyses. We appreciate the technical guidance with hiPSC line production from Outi Melin and Hanna Pekkanen. Furthermore, we thank Iikka Veijola and Alli Lintunen for their technical assistance with analyses. Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = aug,
doi = "10.1016/j.scr.2022.102865",
language = "English",
volume = "63",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",
}
