TY - GEN
T1 - Evaluation of the effective and functional connectivity estimators for microelectrode array recordings during in vitro neuronal network maturation
AU - Kapucu, Emre
AU - Tanskanen, Jarno
AU - Christophe, Francois
AU - Mikkonen, Tommi
AU - Hyttinen, Jari
N1 - jufoid=58152
EXT="Mikkonen, Tommi"
PY - 2018
Y1 - 2018
N2 - During maturation, neurons and neuronal ensembles interact and build connections. Changes in the network structure have effects on the overall electrophysiological activity, and consequently on the observable connectivity. In this paper, we assessed effective and functional connectivities during neuronal network development by means of directed connectivity and synchronization, respectively. For that, we analyzed in vitro dissociated mouse cortical neuronal networks during four weeks using microelectrode arrays.Functional and effective connectivities were estimated with CorSE and transfer entropy (TE), respectively. Here, we describe the advantages of the methods relative to each other. We observed that the functional connectivity analysis may provide networking information in earlier phases of network development than effective connectivity. On the other hand, effective connectivity analysis provides information on the sources and targets of information flows. By corroborative analysis using CorSE and TE, one can investigate possible effects of early synchronizations on information transfer during the later stages of network development. In conclusion, using effective and functional connectivity assessments jointly provides for enhanced analysis of the development of information transfer during the structural development of a neuronal network.
AB - During maturation, neurons and neuronal ensembles interact and build connections. Changes in the network structure have effects on the overall electrophysiological activity, and consequently on the observable connectivity. In this paper, we assessed effective and functional connectivities during neuronal network development by means of directed connectivity and synchronization, respectively. For that, we analyzed in vitro dissociated mouse cortical neuronal networks during four weeks using microelectrode arrays.Functional and effective connectivities were estimated with CorSE and transfer entropy (TE), respectively. Here, we describe the advantages of the methods relative to each other. We observed that the functional connectivity analysis may provide networking information in earlier phases of network development than effective connectivity. On the other hand, effective connectivity analysis provides information on the sources and targets of information flows. By corroborative analysis using CorSE and TE, one can investigate possible effects of early synchronizations on information transfer during the later stages of network development. In conclusion, using effective and functional connectivity assessments jointly provides for enhanced analysis of the development of information transfer during the structural development of a neuronal network.
U2 - 10.1007/978-981-10-5122-7_276
DO - 10.1007/978-981-10-5122-7_276
M3 - Conference contribution
SN - 978-981-10-5121-0
T3 - IFMBE Proceedings
SP - 1105
EP - 1108
BT - EMBEC and NBC 2017 - Joint Conference of the European Medical and Biological Engineering Conference EMBEC 2017 and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2017
PB - Springer Verlag
T2 - Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC)
Y2 - 1 January 1900
ER -