Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases

Laura Räisänen; Heli Viljakainen; Kaija Leena Kolho

doi:10.3389/fped.2023.1157547

Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases

Laura Räisänen, Heli Viljakainen, Kaija Leena Kolho

LAST, Lastentaudit

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

4 Sitaatiot (Scopus)

11 Lataukset (Pure)

Abstrakti

Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD). We investigated whether PPIs are associated with the development of ADs in children and concluded that PPI exposures could be related to the onset of ADs, especially IBD and potentially AIT as well.

Alkuperäiskieli	Englanti
Artikkeli	1157547
Sivumäärä	7
Julkaisu	Frontiers in Pediatrics
Vuosikerta	11
DOI - pysyväislinkit	https://doi.org/10.3389/fped.2023.1157547
Tila	Julkaistu - 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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Pääsy asiakirjaan

10.3389/fped.2023.1157547Lisenssi: CC BY

fped-11-1157547-1Final published version, 1,15 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202305246104Lisenssi: CC BY

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title = "Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases",

abstract = "Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD). We investigated whether PPIs are associated with the development of ADs in children and concluded that PPI exposures could be related to the onset of ADs, especially IBD and potentially AIT as well.",

keywords = "autoimmune thyroiditis, inflammatory bowel diseases, juvenile idiopathic arthritis, omeprazole, type 1 diabetes mellitus",

author = "Laura R{\"a}is{\"a}nen and Heli Viljakainen and Kolho, {Kaija Leena}",

note = "Funding Information: This research is supported by the Finnish government's research fund (VTR_2022, grant number 9AC086 to LR). Publisher Copyright: 2023 R{\"a}is{\"a}nen, Viljakainen and Kolho.",

year = "2023",

doi = "10.3389/fped.2023.1157547",

language = "English",

volume = "11",

}

TY - JOUR

T1 - Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases

AU - Räisänen, Laura

AU - Viljakainen, Heli

AU - Kolho, Kaija Leena

N1 - Funding Information: This research is supported by the Finnish government's research fund (VTR_2022, grant number 9AC086 to LR). Publisher Copyright: 2023 Räisänen, Viljakainen and Kolho.

PY - 2023

Y1 - 2023

N2 - Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD). We investigated whether PPIs are associated with the development of ADs in children and concluded that PPI exposures could be related to the onset of ADs, especially IBD and potentially AIT as well.

AB - Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD). We investigated whether PPIs are associated with the development of ADs in children and concluded that PPI exposures could be related to the onset of ADs, especially IBD and potentially AIT as well.

KW - autoimmune thyroiditis

KW - inflammatory bowel diseases

KW - juvenile idiopathic arthritis

KW - omeprazole

KW - type 1 diabetes mellitus

U2 - 10.3389/fped.2023.1157547

DO - 10.3389/fped.2023.1157547

M3 - Article

AN - SCOPUS:85153342920

SN - 2296-2360

VL - 11

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

M1 - 1157547

ER -

Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases

Abstrakti

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

YK:n kestävän kehityksen tavoitteet

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