Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

S. Ligthart; A. Vaez; U. Võsa; M.G. Stathopoulou; P.S. de Vries; B.P. Prins; P.J. Van der Most; T. Tanaka; E. Naderi; L.M. Rose; Y. Wu; R. Karlsson; M. Barbalic; H. Lin; R. Pool; G. Zhu; A. Macé; C. Sidore; S. Trompet; M. Mangino; M. Sabater-Lleal; J.P. Kemp; A. Abbasi; T. Kacprowski; N. Verweij; A.V. Smith; T. Huang; C. Marzi; M.F. Feitosa; K.K. Lohman; M.E. Kleber; Y. Milaneschi; C. Mueller; M. Huq; E. Vlachopoulou; Leo-Pekka Lyytikäinen; C. Oldmeadow; J. Deelen; M. Perola; J.H. Zhao; B. Feenstra; B.Z. Alizadeh; H.M. Boezen; L. Franke; P van der Harst; Mika Kähönen; Terho Lehtimäki

doi:10.1016/j.ajhg.2018.09.009

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

S. Ligthart
, A. Vaez
, U. Võsa
, M.G. Stathopoulou
, P.S. de Vries
, B.P. Prins
, P.J. Van der Most
, T. Tanaka
, E. Naderi
, L.M. Rose
, Y. Wu
, R. Karlsson
, M. Barbalic
, H. Lin
, R. Pool
, G. Zhu
, A. Macé
, C. Sidore
, S. Trompet
, M. Mangino

M. Sabater-Lleal, J.P. Kemp, A. Abbasi, T. Kacprowski, N. Verweij, A.V. Smith, T. Huang, C. Marzi, M.F. Feitosa, K.K. Lohman, M.E. Kleber, Y. Milaneschi, C. Mueller, M. Huq, E. Vlachopoulou, Leo-Pekka Lyytikäinen, C. Oldmeadow, J. Deelen, M. Perola, J.H. Zhao, B. Feenstra, B.Z. Alizadeh, H.M. Boezen, L. Franke, P van der Harst, Mika Kähönen, Terho Lehtimäki

Kliinisen kemian yksikkö

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

332 Sitaatiot (Scopus)

Alkuperäiskieli	Englanti
Sivut	691-706
Julkaisu	American Journal of Human Genetics
Vuosikerta	103
Numero	5
DOI - pysyväislinkit	https://doi.org/10.1016/j.ajhg.2018.09.009
Tila	Julkaistu - 2018
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Tutkimusalat

C-reactive protein
DEPICT
Mendelian randomization
coronary artery disease
genome-wide association study
inflammation
inflammatory disorders
schizophrenia
system biology

Julkaisufoorumi-taso

Jufo-taso 3

Pääsy asiakirjaan

10.1016/j.ajhg.2018.09.009

Siteeraa tätä

Ligthart, S., Vaez, A., Võsa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., Van der Most, P. J., Tanaka, T., Naderi, E., Rose, L. M., Wu, Y., Karlsson, R., Barbalic, M., Lin, H., Pool, R., Zhu, G., Macé, A., Sidore, C., Trompet, S., ... Lehtimäki, T. (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. American Journal of Human Genetics, 103(5), 691-706. https://doi.org/10.1016/j.ajhg.2018.09.009

@article{fd7f951eb4124200bf1f246a0c82bf4e,

title = "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders",

keywords = "C-reactive protein, DEPICT, Mendelian randomization, coronary artery disease, genome-wide association study, inflammation, inflammatory disorders, schizophrenia, system biology, C-reactive protein, DEPICT, Mendelian randomization, coronary artery disease, genome-wide association study, inflammation, inflammatory disorders, schizophrenia, system biology",

author = "S. Ligthart and A. Vaez and U. V{\~o}sa and M.G. Stathopoulou and \{de Vries\}, P.S. and B.P. Prins and \{Van der Most\}, P.J. and T. Tanaka and E. Naderi and L.M. Rose and Y. Wu and R. Karlsson and M. Barbalic and H. Lin and R. Pool and G. Zhu and A. Mac{\'e} and C. Sidore and S. Trompet and M. Mangino and M. Sabater-Lleal and J.P. Kemp and A. Abbasi and T. Kacprowski and N. Verweij and A.V. Smith and T. Huang and C. Marzi and M.F. Feitosa and K.K. Lohman and M.E. Kleber and Y. Milaneschi and C. Mueller and M. Huq and E. Vlachopoulou and Leo-Pekka Lyytik{\"a}inen and C. Oldmeadow and J. Deelen and M. Perola and J.H. Zhao and B. Feenstra and B.Z. Alizadeh and H.M. Boezen and L. Franke and \{van der Harst\}, P and Mika K{\"a}h{\"o}nen and Terho Lehtim{\"a}ki",

year = "2018",

doi = "10.1016/j.ajhg.2018.09.009",

language = "English",

volume = "103",

pages = "691--706",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "5",

}

Ligthart, S, Vaez, A, Võsa, U, Stathopoulou, MG, de Vries, PS, Prins, BP, Van der Most, PJ, Tanaka, T, Naderi, E, Rose, LM, Wu, Y, Karlsson, R, Barbalic, M, Lin, H, Pool, R, Zhu, G, Macé, A, Sidore, C, Trompet, S, Mangino, M, Sabater-Lleal, M, Kemp, JP, Abbasi, A, Kacprowski, T, Verweij, N, Smith, AV, Huang, T, Marzi, C, Feitosa, MF, Lohman, KK, Kleber, ME, Milaneschi, Y, Mueller, C, Huq, M, Vlachopoulou, E, Lyytikäinen, L-P, Oldmeadow, C, Deelen, J, Perola, M, Zhao, JH, Feenstra, B, Alizadeh, BZ, Boezen, HM, Franke, L, van der Harst, P, Kähönen, M & Lehtimäki, T 2018, 'Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders', American Journal of Human Genetics, Vuosikerta 103, Nro 5, Sivut 691-706. https://doi.org/10.1016/j.ajhg.2018.09.009

TY - JOUR

T1 - Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

AU - Ligthart, S.

AU - Vaez, A.

AU - Võsa, U.

AU - Stathopoulou, M.G.

AU - de Vries, P.S.

AU - Prins, B.P.

AU - Van der Most, P.J.

AU - Tanaka, T.

AU - Naderi, E.

AU - Rose, L.M.

AU - Wu, Y.

AU - Karlsson, R.

AU - Barbalic, M.

AU - Lin, H.

AU - Pool, R.

AU - Zhu, G.

AU - Macé, A.

AU - Sidore, C.

AU - Trompet, S.

AU - Mangino, M.

AU - Sabater-Lleal, M.

AU - Kemp, J.P.

AU - Abbasi, A.

AU - Kacprowski, T.

AU - Verweij, N.

AU - Smith, A.V.

AU - Huang, T.

AU - Marzi, C.

AU - Feitosa, M.F.

AU - Lohman, K.K.

AU - Kleber, M.E.

AU - Milaneschi, Y.

AU - Mueller, C.

AU - Huq, M.

AU - Vlachopoulou, E.

AU - Lyytikäinen, Leo-Pekka

AU - Oldmeadow, C.

AU - Deelen, J.

AU - Perola, M.

AU - Zhao, J.H.

AU - Feenstra, B.

AU - Alizadeh, B.Z.

AU - Boezen, H.M.

AU - Franke, L.

AU - van der Harst, P

AU - Kähönen, Mika

AU - Lehtimäki, Terho

PY - 2018

Y1 - 2018

KW - C-reactive protein

KW - DEPICT

KW - Mendelian randomization

KW - coronary artery disease

KW - genome-wide association study

KW - inflammation

KW - inflammatory disorders

KW - schizophrenia

KW - system biology

KW - C-reactive protein

KW - DEPICT

KW - Mendelian randomization

KW - coronary artery disease

KW - genome-wide association study

KW - inflammation

KW - inflammatory disorders

KW - schizophrenia

KW - system biology

U2 - 10.1016/j.ajhg.2018.09.009

DO - 10.1016/j.ajhg.2018.09.009

M3 - Article

SN - 0002-9297

VL - 103

SP - 691

EP - 706

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 5

ER -