Graphical Tasks to Measure Upper Limb Function in Patients With Parkinson's Disease: Validity and Response to Dopaminergic Medication

Esther J. Smits; Antti J. Tolonen; Luc Cluitmans; Mark Van Gils; Rutger C. Zietsma; Robbert W.K. Borgemeester; Teus Van Laar; Natasha M. Maurits

doi:10.1109/JBHI.2015.2503802

Graphical Tasks to Measure Upper Limb Function in Patients With Parkinson's Disease: Validity and Response to Dopaminergic Medication

Esther J. Smits, Antti J. Tolonen, Luc Cluitmans, Mark Van Gils, Rutger C. Zietsma, Robbert W.K. Borgemeester, Teus Van Laar, Natasha M. Maurits

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

22 Sitaatiot (Scopus)

Abstrakti

The most widely used method to assess motor functioning in Parkinson's disease (PD) patients is the unified Parkinson's disease rating scale-III (UPDRS-III). The UPDRS-III has limited ability to detect subtle changes in motor symptoms. Alternatively, graphical tasks can be used to provide objective measures of upper limb motor dysfunction. This study investigated the validity of such graphical tasks to assess upper limb function in PD patients and their ability to detect subtle changes in performance. Fourteen PD patients performed graphical tasks before and after taking dopaminergic medication. Graphical tasks included figure tracing, writing, and a modified Fitts' task. The Purdue pegboard test was performed to validate these graphical tasks. Movement time (MT), writing size, and the presence of tremor were assessed. MT on the graphical tasks correlated significantly with performance on the Purdue pegboard test (Spearman's ρ > 0.65; p < 0.05). MT decreased significantly after the intake of dopaminergic medication. Tremor power decreased after taking dopaminergic medication in most PD patients who suffered from tremor. Writing size did not correlate with performance on the Purdue pegboard test, nor did it change after taking medication. Our set of graphical tasks is valid to assess upper limb function in PD patients. MT proved to be the most useful measure for this purpose. The response on dopaminergic medication was optimally reflected by an improved MT on the graphical tasks in combination with a decreased tremor power, whereas writing size did not respond to dopaminergic treatment.

Alkuperäiskieli	Englanti
Sivut	283-289
Sivumäärä	7
Julkaisu	IEEE Journal of Biomedical and Health Informatics
Vuosikerta	21
Numero	1
DOI - pysyväislinkit	https://doi.org/10.1109/JBHI.2015.2503802
Tila	Julkaistu - tammik. 2017
Julkaistu ulkoisesti	Kyllä
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

!!ASJC Scopus subject areas

Biotechnology
Computer Science Applications
Electrical and Electronic Engineering
Health Information Management

Pääsy asiakirjaan

10.1109/JBHI.2015.2503802

Siteeraa tätä

Smits, E. J., Tolonen, A. J., Cluitmans, L., Van Gils, M., Zietsma, R. C., Borgemeester, R. W. K., Van Laar, T., & Maurits, N. M. (2017). Graphical Tasks to Measure Upper Limb Function in Patients With Parkinson's Disease: Validity and Response to Dopaminergic Medication. IEEE Journal of Biomedical and Health Informatics, 21(1), 283-289. https://doi.org/10.1109/JBHI.2015.2503802

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title = "Graphical Tasks to Measure Upper Limb Function in Patients With Parkinson's Disease: Validity and Response to Dopaminergic Medication",

abstract = "The most widely used method to assess motor functioning in Parkinson's disease (PD) patients is the unified Parkinson's disease rating scale-III (UPDRS-III). The UPDRS-III has limited ability to detect subtle changes in motor symptoms. Alternatively, graphical tasks can be used to provide objective measures of upper limb motor dysfunction. This study investigated the validity of such graphical tasks to assess upper limb function in PD patients and their ability to detect subtle changes in performance. Fourteen PD patients performed graphical tasks before and after taking dopaminergic medication. Graphical tasks included figure tracing, writing, and a modified Fitts' task. The Purdue pegboard test was performed to validate these graphical tasks. Movement time (MT), writing size, and the presence of tremor were assessed. MT on the graphical tasks correlated significantly with performance on the Purdue pegboard test (Spearman's ρ > 0.65; p < 0.05). MT decreased significantly after the intake of dopaminergic medication. Tremor power decreased after taking dopaminergic medication in most PD patients who suffered from tremor. Writing size did not correlate with performance on the Purdue pegboard test, nor did it change after taking medication. Our set of graphical tasks is valid to assess upper limb function in PD patients. MT proved to be the most useful measure for this purpose. The response on dopaminergic medication was optimally reflected by an improved MT on the graphical tasks in combination with a decreased tremor power, whereas writing size did not respond to dopaminergic treatment.",

keywords = "Bradykinesia, drawing, graphical tasks, handwriting, micrographia, Parkinson's disease, tremor, upper limb function, validity",

author = "Smits, {Esther J.} and Tolonen, {Antti J.} and Luc Cluitmans and {Van Gils}, Mark and Zietsma, {Rutger C.} and Borgemeester, {Robbert W.K.} and {Van Laar}, Teus and Maurits, {Natasha M.}",

note = "Funding Information: Manuscript received June 11, 2015; revised October 12, 2015; accepted November 18, 2015. Date of publication November 25, 2015; date of current version January 31, 2017. This paper has supplementary downloadable material available at http://ieeexplore.ieee.org. This work is a part of the DiPAR Project which was supported by the EC in the FP7-SME-201001 Program (Grant Agreement 262291). Funding Information: The authors would like to thank H. Giezen and M. Folkerts, Master students of Human Movement Sciences at the University of Groningen, the Netherlands, who performed most of the measurements. The hardware of the measurement setup was provided by Fraunhofer IPMS (Dresden, Germany) and the data acquisition software by Fraunhofer IPA (Stuttgart, Germany), based on a concept by Manus Neurodynamica, Ltd. (patent WO/2011/141734). Publisher Copyright: {\textcopyright} 2016 IEEE.",

year = "2017",

month = jan,

doi = "10.1109/JBHI.2015.2503802",

language = "English",

volume = "21",

pages = "283--289",

journal = "IEEE Journal of Biomedical and Health Informatics",

issn = "2168-2194",

publisher = "IEEE",

number = "1",

}

Smits, EJ, Tolonen, AJ, Cluitmans, L, Van Gils, M, Zietsma, RC, Borgemeester, RWK, Van Laar, T & Maurits, NM 2017, 'Graphical Tasks to Measure Upper Limb Function in Patients With Parkinson's Disease: Validity and Response to Dopaminergic Medication', IEEE Journal of Biomedical and Health Informatics, Vuosikerta 21, Nro 1, Sivut 283-289. https://doi.org/10.1109/JBHI.2015.2503802

TY - JOUR

T1 - Graphical Tasks to Measure Upper Limb Function in Patients With Parkinson's Disease

T2 - Validity and Response to Dopaminergic Medication

AU - Smits, Esther J.

AU - Tolonen, Antti J.

AU - Cluitmans, Luc

AU - Van Gils, Mark

AU - Zietsma, Rutger C.

AU - Borgemeester, Robbert W.K.

AU - Van Laar, Teus

AU - Maurits, Natasha M.

N1 - Funding Information: Manuscript received June 11, 2015; revised October 12, 2015; accepted November 18, 2015. Date of publication November 25, 2015; date of current version January 31, 2017. This paper has supplementary downloadable material available at http://ieeexplore.ieee.org. This work is a part of the DiPAR Project which was supported by the EC in the FP7-SME-201001 Program (Grant Agreement 262291). Funding Information: The authors would like to thank H. Giezen and M. Folkerts, Master students of Human Movement Sciences at the University of Groningen, the Netherlands, who performed most of the measurements. The hardware of the measurement setup was provided by Fraunhofer IPMS (Dresden, Germany) and the data acquisition software by Fraunhofer IPA (Stuttgart, Germany), based on a concept by Manus Neurodynamica, Ltd. (patent WO/2011/141734). Publisher Copyright: © 2016 IEEE.

PY - 2017/1

Y1 - 2017/1

N2 - The most widely used method to assess motor functioning in Parkinson's disease (PD) patients is the unified Parkinson's disease rating scale-III (UPDRS-III). The UPDRS-III has limited ability to detect subtle changes in motor symptoms. Alternatively, graphical tasks can be used to provide objective measures of upper limb motor dysfunction. This study investigated the validity of such graphical tasks to assess upper limb function in PD patients and their ability to detect subtle changes in performance. Fourteen PD patients performed graphical tasks before and after taking dopaminergic medication. Graphical tasks included figure tracing, writing, and a modified Fitts' task. The Purdue pegboard test was performed to validate these graphical tasks. Movement time (MT), writing size, and the presence of tremor were assessed. MT on the graphical tasks correlated significantly with performance on the Purdue pegboard test (Spearman's ρ > 0.65; p < 0.05). MT decreased significantly after the intake of dopaminergic medication. Tremor power decreased after taking dopaminergic medication in most PD patients who suffered from tremor. Writing size did not correlate with performance on the Purdue pegboard test, nor did it change after taking medication. Our set of graphical tasks is valid to assess upper limb function in PD patients. MT proved to be the most useful measure for this purpose. The response on dopaminergic medication was optimally reflected by an improved MT on the graphical tasks in combination with a decreased tremor power, whereas writing size did not respond to dopaminergic treatment.

AB - The most widely used method to assess motor functioning in Parkinson's disease (PD) patients is the unified Parkinson's disease rating scale-III (UPDRS-III). The UPDRS-III has limited ability to detect subtle changes in motor symptoms. Alternatively, graphical tasks can be used to provide objective measures of upper limb motor dysfunction. This study investigated the validity of such graphical tasks to assess upper limb function in PD patients and their ability to detect subtle changes in performance. Fourteen PD patients performed graphical tasks before and after taking dopaminergic medication. Graphical tasks included figure tracing, writing, and a modified Fitts' task. The Purdue pegboard test was performed to validate these graphical tasks. Movement time (MT), writing size, and the presence of tremor were assessed. MT on the graphical tasks correlated significantly with performance on the Purdue pegboard test (Spearman's ρ > 0.65; p < 0.05). MT decreased significantly after the intake of dopaminergic medication. Tremor power decreased after taking dopaminergic medication in most PD patients who suffered from tremor. Writing size did not correlate with performance on the Purdue pegboard test, nor did it change after taking medication. Our set of graphical tasks is valid to assess upper limb function in PD patients. MT proved to be the most useful measure for this purpose. The response on dopaminergic medication was optimally reflected by an improved MT on the graphical tasks in combination with a decreased tremor power, whereas writing size did not respond to dopaminergic treatment.

KW - Bradykinesia

KW - drawing

KW - graphical tasks

KW - handwriting

KW - micrographia

KW - Parkinson's disease

KW - tremor

KW - upper limb function

KW - validity

U2 - 10.1109/JBHI.2015.2503802

DO - 10.1109/JBHI.2015.2503802

M3 - Article

C2 - 26625435

AN - SCOPUS:85019259920

SN - 2168-2194

VL - 21

SP - 283

EP - 289

JO - IEEE Journal of Biomedical and Health Informatics

JF - IEEE Journal of Biomedical and Health Informatics

IS - 1

ER -

Graphical Tasks to Measure Upper Limb Function in Patients With Parkinson's Disease: Validity and Response to Dopaminergic Medication

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!!ASJC Scopus subject areas

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