Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution

L. Zeng; D. Sirbu; P. G. Waddell; N. V. Tkachenko; M. R. Probert; A. C. Benniston

doi:10.1039/d0dt02339f

Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)₂(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution

L. Zeng, D. Sirbu, P. G. Waddell, N. V. Tkachenko, M. R. Probert, A. C. Benniston

Materiaalitiede ja ympäristötekniikka

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

6 Sitaatiot (Scopus)

14 Lataukset (Pure)

Abstrakti

A new class of light-activated ruthenium(ii) complex was designed as a potential blocker of biological functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)₂(1-hydroxyanthra-9,10 quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behaviour through a series of stability tests, electrochemistry, UV-Visible kinetics and femtosecond transient absorption spectroscopy experiments. Under white light in the presence of H₂O₂two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(iii) or Ru(v) species is produced. The complexRU1shows potential to consume H₂O₂from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.

Alkuperäiskieli	Englanti
Sivut	13243-13252
Sivumäärä	10
Julkaisu	DALTON TRANSACTIONS
Vuosikerta	49
Numero	38
DOI - pysyväislinkit	https://doi.org/10.1039/d0dt02339f
Tila	Julkaistu - 2020
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

We thank the Royal Society of Chemistry Researcher Mobility Grant for financial support. We also thank the National Mass Spectrometry Facility at Swansea University for collecting mass spectra of the compounds and Dr Helen Waller from FMS at Newcastle University for help with the CD spectra. We would also like to thank Diamond Light Source for access to beam-line I19.

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Inorganic Chemistry

Pääsy asiakirjaan

10.1039/d0dt02339fLisenssi: CC BY

Hydrogen peroxide assisted photorelease 2020
CC BY
Final published version, 1,26 MBLisenssi: CC BY

http://urn.fi/URN:NBN:fi:tuni-202011308305Lisenssi: CC BY

CCDC 2013315: Experimental Crystal Structure Determination
Zeng, L. (Contributor), Sirbu, D. (Contributor), Waddell, P. G. (Contributor), Tkachenko, N. V. (Creator), Probert, M. R. (Contributor) & Benniston, A. C. (Contributor), Cambridge Crystallographic Data Centre, 1 heinäk. 2020
DOI - pysyväislinkki: 10.5517/ccdc.csd.cc25l0ng
Tietoaineisto: Dataset

Siteeraa tätä

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title = "Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution",

abstract = "A new class of light-activated ruthenium(ii) complex was designed as a potential blocker of biological functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)2(1-hydroxyanthra-9,10 quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behaviour through a series of stability tests, electrochemistry, UV-Visible kinetics and femtosecond transient absorption spectroscopy experiments. Under white light in the presence of H2O2two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(iii) or Ru(v) species is produced. The complexRU1shows potential to consume H2O2from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.",

author = "L. Zeng and D. Sirbu and Waddell, {P. G.} and Tkachenko, {N. V.} and Probert, {M. R.} and Benniston, {A. C.}",

note = "Funding Information: We thank the Royal Society of Chemistry Researcher Mobility Grant for financial support. We also thank the National Mass Spectrometry Facility at Swansea University for collecting mass spectra of the compounds and Dr Helen Waller from FMS at Newcastle University for help with the CD spectra. We would also like to thank Diamond Light Source for access to beam-line I19. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

doi = "10.1039/d0dt02339f",

language = "English",

volume = "49",

pages = "13243--13252",

journal = "DALTON TRANSACTIONS",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution

AU - Zeng, L.

AU - Sirbu, D.

AU - Waddell, P. G.

AU - Tkachenko, N. V.

AU - Probert, M. R.

AU - Benniston, A. C.

N1 - Funding Information: We thank the Royal Society of Chemistry Researcher Mobility Grant for financial support. We also thank the National Mass Spectrometry Facility at Swansea University for collecting mass spectra of the compounds and Dr Helen Waller from FMS at Newcastle University for help with the CD spectra. We would also like to thank Diamond Light Source for access to beam-line I19. Publisher Copyright: © The Royal Society of Chemistry 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - A new class of light-activated ruthenium(ii) complex was designed as a potential blocker of biological functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)2(1-hydroxyanthra-9,10 quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behaviour through a series of stability tests, electrochemistry, UV-Visible kinetics and femtosecond transient absorption spectroscopy experiments. Under white light in the presence of H2O2two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(iii) or Ru(v) species is produced. The complexRU1shows potential to consume H2O2from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.

AB - A new class of light-activated ruthenium(ii) complex was designed as a potential blocker of biological functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)2(1-hydroxyanthra-9,10 quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behaviour through a series of stability tests, electrochemistry, UV-Visible kinetics and femtosecond transient absorption spectroscopy experiments. Under white light in the presence of H2O2two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(iii) or Ru(v) species is produced. The complexRU1shows potential to consume H2O2from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.

U2 - 10.1039/d0dt02339f

DO - 10.1039/d0dt02339f

M3 - Article

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SN - 1477-9226

VL - 49

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EP - 13252

JO - DALTON TRANSACTIONS

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