Hypertensive disorders in pregnancy and cognitive decline in the offspring up to old age

Soile Tuovinen; Katri Räikkönen; Eero Kajantie; Markus Henriksson; Jukka T. Leskinen; Anu Katriina Pesonen; Kati Heinonen; Jari Lahti; Riikka Pyhälä; Hanna Alastalo; Marius Lahti; Clive Osmond; David J.P. Barker; Johan G. Eriksson

doi:10.1212/WNL.0b013e31826e2606

Hypertensive disorders in pregnancy and cognitive decline in the offspring up to old age

Soile Tuovinen
, Katri Räikkönen^*
, Eero Kajantie
, Markus Henriksson
, Jukka T. Leskinen
, Anu Katriina Pesonen
, Kati Heinonen
, Jari Lahti
, Riikka Pyhälä
, Hanna Alastalo
, Marius Lahti
, Clive Osmond
, David J.P. Barker
, Johan G. Eriksson

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

58 Sitaatiot (Scopus)

Abstrakti

Objective: We tested whether maternal hypertensive disorders in pregnancy predict age-related change in cognitive ability in the offspring up to old age. Methods: Using mothers' blood pressure and urinary protein measurements from the maternity clinics and birth hospitals, we defined normotensive or hypertensive pregnancies in mothers of 398 men, who participated in the Helsinki Birth Cohort 1934-1944 Study. The men underwent the Finnish Defence Forces basic ability test twice: first during compulsory military service at age 20.1 (SD = 1.4) years and then in a retest at age 68.5 (SD = 2.9) years. The test yields a total score and subscores for tests measuring verbal, arithmetic, and visuospatial reasoning. Results: Men born after pregnancies complicated by a hypertensive disorder, compared with men born after normotensive pregnancies, scored 4.36 (95% confidence interval, 1.17-7.55) points lower on total cognitive ability at 68.5 years and displayed a greater decline in total cognitive ability (2.88; 95% confidence interval, 0.07-5.06) after 20.1 years. Of the subscores, associations were strongest for arithmetic reasoning. Conclusion: Maternal hypertensive disorders in pregnancy predict lower cognitive ability and greater cognitive decline up to old age. A propensity to lower cognitive ability and decline up to old age may have prenatal origins.

Alkuperäiskieli	Englanti
Sivut	1578-1582
Sivumäärä	5
Julkaisu	Neurology
Vuosikerta	79
Numero	15
DOI - pysyväislinkit	https://doi.org/10.1212/WNL.0b013e31826e2606
Tila	Julkaistu - 9 lokak. 2012
Julkaistu ulkoisesti	Kyllä
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

Study funding: Supported by grants from the Academy of Finland, European Science Foundation (EuroSTRESS), University of Helsinki, the British Heart Foundation, the Finnish Foundation of Cardiovascular Research, the Finnish Diabetes Research Foundation, the Finnish Medical Society (Duodecim), Finska Läkaresällskapet, the National Doctoral Programme of Psychology, the Päivikki and Sakari Sohlberg Foundation, the Juho Vainio Foundation, the Yrjö Jahnsson Foundation, the Signe and Ane Gyllenberg Foundation, the Jalmari and Rauha Ahokas Foundation, the Emil Aaltonen Foundation, the Finnish Ministry of Education, and the Finnish Foundation for Paediatric Research.

!!ASJC Scopus subject areas

Clinical Neurology

Pääsy asiakirjaan

10.1212/WNL.0b013e31826e2606

Siteeraa tätä

Tuovinen, S., Räikkönen, K., Kajantie, E., Henriksson, M., Leskinen, J. T., Pesonen, A. K., Heinonen, K., Lahti, J., Pyhälä, R., Alastalo, H., Lahti, M., Osmond, C., Barker, D. J. P., & Eriksson, J. G. (2012). Hypertensive disorders in pregnancy and cognitive decline in the offspring up to old age. Neurology, 79(15), 1578-1582. https://doi.org/10.1212/WNL.0b013e31826e2606

@article{c1e3fe0776e7463bbe72c0ce5780dde7,

title = "Hypertensive disorders in pregnancy and cognitive decline in the offspring up to old age",

abstract = "Objective: We tested whether maternal hypertensive disorders in pregnancy predict age-related change in cognitive ability in the offspring up to old age. Methods: Using mothers' blood pressure and urinary protein measurements from the maternity clinics and birth hospitals, we defined normotensive or hypertensive pregnancies in mothers of 398 men, who participated in the Helsinki Birth Cohort 1934-1944 Study. The men underwent the Finnish Defence Forces basic ability test twice: first during compulsory military service at age 20.1 (SD = 1.4) years and then in a retest at age 68.5 (SD = 2.9) years. The test yields a total score and subscores for tests measuring verbal, arithmetic, and visuospatial reasoning. Results: Men born after pregnancies complicated by a hypertensive disorder, compared with men born after normotensive pregnancies, scored 4.36 (95\% confidence interval, 1.17-7.55) points lower on total cognitive ability at 68.5 years and displayed a greater decline in total cognitive ability (2.88; 95\% confidence interval, 0.07-5.06) after 20.1 years. Of the subscores, associations were strongest for arithmetic reasoning. Conclusion: Maternal hypertensive disorders in pregnancy predict lower cognitive ability and greater cognitive decline up to old age. A propensity to lower cognitive ability and decline up to old age may have prenatal origins.",

author = "Soile Tuovinen and Katri R{\"a}ikk{\"o}nen and Eero Kajantie and Markus Henriksson and Leskinen, \{Jukka T.\} and Pesonen, \{Anu Katriina\} and Kati Heinonen and Jari Lahti and Riikka Pyh{\"a}l{\"a} and Hanna Alastalo and Marius Lahti and Clive Osmond and Barker, \{David J.P.\} and Eriksson, \{Johan G.\}",

note = "Funding Information: Study funding: Supported by grants from the Academy of Finland, European Science Foundation (EuroSTRESS), University of Helsinki, the British Heart Foundation, the Finnish Foundation of Cardiovascular Research, the Finnish Diabetes Research Foundation, the Finnish Medical Society (Duodecim), Finska L{\"a}kares{\"a}llskapet, the National Doctoral Programme of Psychology, the P{\"a}ivikki and Sakari Sohlberg Foundation, the Juho Vainio Foundation, the Yrj{\"o} Jahnsson Foundation, the Signe and Ane Gyllenberg Foundation, the Jalmari and Rauha Ahokas Foundation, the Emil Aaltonen Foundation, the Finnish Ministry of Education, and the Finnish Foundation for Paediatric Research. ",

year = "2012",

month = oct,

day = "9",

doi = "10.1212/WNL.0b013e31826e2606",

language = "English",

volume = "79",

pages = "1578--1582",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "15",

}

Tuovinen, S, Räikkönen, K, Kajantie, E, Henriksson, M, Leskinen, JT, Pesonen, AK, Heinonen, K, Lahti, J, Pyhälä, R, Alastalo, H, Lahti, M, Osmond, C, Barker, DJP & Eriksson, JG 2012, 'Hypertensive disorders in pregnancy and cognitive decline in the offspring up to old age', Neurology, Vuosikerta 79, Nro 15, Sivut 1578-1582. https://doi.org/10.1212/WNL.0b013e31826e2606

TY - JOUR

T1 - Hypertensive disorders in pregnancy and cognitive decline in the offspring up to old age

AU - Tuovinen, Soile

AU - Räikkönen, Katri

AU - Kajantie, Eero

AU - Henriksson, Markus

AU - Leskinen, Jukka T.

AU - Pesonen, Anu Katriina

AU - Heinonen, Kati

AU - Lahti, Jari

AU - Pyhälä, Riikka

AU - Alastalo, Hanna

AU - Lahti, Marius

AU - Osmond, Clive

AU - Barker, David J.P.

AU - Eriksson, Johan G.

N1 - Funding Information: Study funding: Supported by grants from the Academy of Finland, European Science Foundation (EuroSTRESS), University of Helsinki, the British Heart Foundation, the Finnish Foundation of Cardiovascular Research, the Finnish Diabetes Research Foundation, the Finnish Medical Society (Duodecim), Finska Läkaresällskapet, the National Doctoral Programme of Psychology, the Päivikki and Sakari Sohlberg Foundation, the Juho Vainio Foundation, the Yrjö Jahnsson Foundation, the Signe and Ane Gyllenberg Foundation, the Jalmari and Rauha Ahokas Foundation, the Emil Aaltonen Foundation, the Finnish Ministry of Education, and the Finnish Foundation for Paediatric Research.

PY - 2012/10/9

Y1 - 2012/10/9

N2 - Objective: We tested whether maternal hypertensive disorders in pregnancy predict age-related change in cognitive ability in the offspring up to old age. Methods: Using mothers' blood pressure and urinary protein measurements from the maternity clinics and birth hospitals, we defined normotensive or hypertensive pregnancies in mothers of 398 men, who participated in the Helsinki Birth Cohort 1934-1944 Study. The men underwent the Finnish Defence Forces basic ability test twice: first during compulsory military service at age 20.1 (SD = 1.4) years and then in a retest at age 68.5 (SD = 2.9) years. The test yields a total score and subscores for tests measuring verbal, arithmetic, and visuospatial reasoning. Results: Men born after pregnancies complicated by a hypertensive disorder, compared with men born after normotensive pregnancies, scored 4.36 (95% confidence interval, 1.17-7.55) points lower on total cognitive ability at 68.5 years and displayed a greater decline in total cognitive ability (2.88; 95% confidence interval, 0.07-5.06) after 20.1 years. Of the subscores, associations were strongest for arithmetic reasoning. Conclusion: Maternal hypertensive disorders in pregnancy predict lower cognitive ability and greater cognitive decline up to old age. A propensity to lower cognitive ability and decline up to old age may have prenatal origins.

AB - Objective: We tested whether maternal hypertensive disorders in pregnancy predict age-related change in cognitive ability in the offspring up to old age. Methods: Using mothers' blood pressure and urinary protein measurements from the maternity clinics and birth hospitals, we defined normotensive or hypertensive pregnancies in mothers of 398 men, who participated in the Helsinki Birth Cohort 1934-1944 Study. The men underwent the Finnish Defence Forces basic ability test twice: first during compulsory military service at age 20.1 (SD = 1.4) years and then in a retest at age 68.5 (SD = 2.9) years. The test yields a total score and subscores for tests measuring verbal, arithmetic, and visuospatial reasoning. Results: Men born after pregnancies complicated by a hypertensive disorder, compared with men born after normotensive pregnancies, scored 4.36 (95% confidence interval, 1.17-7.55) points lower on total cognitive ability at 68.5 years and displayed a greater decline in total cognitive ability (2.88; 95% confidence interval, 0.07-5.06) after 20.1 years. Of the subscores, associations were strongest for arithmetic reasoning. Conclusion: Maternal hypertensive disorders in pregnancy predict lower cognitive ability and greater cognitive decline up to old age. A propensity to lower cognitive ability and decline up to old age may have prenatal origins.

U2 - 10.1212/WNL.0b013e31826e2606

DO - 10.1212/WNL.0b013e31826e2606

M3 - Article

C2 - 23035059

AN - SCOPUS:84867547528

SN - 0028-3878

VL - 79

SP - 1578

EP - 1582

JO - Neurology

JF - Neurology

IS - 15

ER -

Hypertensive disorders in pregnancy and cognitive decline in the offspring up to old age

Abstrakti

Rahoitus

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

Siteeraa tätä