INSM1, a novel biomarker for detection of neuroendocrine neoplasms: Cytopathologists’ view

Zahra Maleki; Akash Nadella; Mohnish Nadella; Gopi Patel; Shivni Patel; Ivana Kholová

doi:10.3390/diagnostics11122172

INSM1, a novel biomarker for detection of neuroendocrine neoplasms: Cytopathologists’ view

Zahra Maleki^*
, Akash Nadella
, Mohnish Nadella
, Gopi Patel
, Shivni Patel
, Ivana Kholová

^*Tämän työn vastaava kirjoittaja

Patologian yksikkö

Tutkimustuotos: Katsausartikkeli › vertaisarvioitu

40 Sitaatiot (Scopus)

12 Lataukset (Pure)

Abstrakti

Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In this review, we summarize existing literature on INSM1^′ s reliability as an immunostain for detection of various NETs, its results in comparison to first-generation NET biomarkers, and its expression in both non-NETs and benign tissues/cells on cytology specimens (cell blocks/smears).

Alkuperäiskieli	Englanti
Artikkeli	2172
Julkaisu	Diagnostics
Vuosikerta	11
Numero	12
DOI - pysyväislinkit	https://doi.org/10.3390/diagnostics11122172
Tila	Julkaistu - marrask. 2021
OKM-julkaisutyyppi	A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Rahoitus

Funding: Grant support: IK is financially supported by VTR grant from Pirkanmaa Hospital District, Tampere Tuberculosis Foundation and Tampere University Support Foundation, Tampere University Hospital. Grant support: IK is financially supported by VTR grant from Pirkanmaa Hospital Dis-trict, Tampere Tuberculosis Foundation and Tampere University Support Foundation, Tampere University Hospital.

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Clinical Biochemistry

Pääsy asiakirjaan

10.3390/diagnostics11122172Lisenssi: CC BY

diagnostics-11-02172-v3Final published version, 69,5 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202112129138Lisenssi: CC BY

Siteeraa tätä

@article{ff97576436024afe872137a9a50e51c6,

title = "INSM1, a novel biomarker for detection of neuroendocrine neoplasms: Cytopathologists{\textquoteright} view",

abstract = "Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In this review, we summarize existing literature on INSM1′ s reliability as an immunostain for detection of various NETs, its results in comparison to first-generation NET biomarkers, and its expression in both non-NETs and benign tissues/cells on cytology specimens (cell blocks/smears).",

keywords = "Carcinoid, Cytology, INSM-1 immunostaining, Medullary thyroid carcinoma, Neuroendocrine tumor, Pancreatic neuroendocrine tumor, Pulmonary neuroendocrine neoplasms",

author = "Zahra Maleki and Akash Nadella and Mohnish Nadella and Gopi Patel and Shivni Patel and Ivana Kholov{\'a}",

note = "Funding Information: Funding: Grant support: IK is financially supported by VTR grant from Pirkanmaa Hospital District, Tampere Tuberculosis Foundation and Tampere University Support Foundation, Tampere University Hospital. Funding Information: Grant support: IK is financially supported by VTR grant from Pirkanmaa Hospital Dis-trict, Tampere Tuberculosis Foundation and Tampere University Support Foundation, Tampere University Hospital.",

year = "2021",

month = nov,

doi = "10.3390/diagnostics11122172",

language = "English",

volume = "11",

journal = "Diagnostics",

issn = "2075-4418",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

}

TY - JOUR

T1 - INSM1, a novel biomarker for detection of neuroendocrine neoplasms

T2 - Cytopathologists’ view

AU - Maleki, Zahra

AU - Nadella, Akash

AU - Nadella, Mohnish

AU - Patel, Gopi

AU - Patel, Shivni

AU - Kholová, Ivana

N1 - Funding Information: Funding: Grant support: IK is financially supported by VTR grant from Pirkanmaa Hospital District, Tampere Tuberculosis Foundation and Tampere University Support Foundation, Tampere University Hospital. Funding Information: Grant support: IK is financially supported by VTR grant from Pirkanmaa Hospital Dis-trict, Tampere Tuberculosis Foundation and Tampere University Support Foundation, Tampere University Hospital.

PY - 2021/11

Y1 - 2021/11

N2 - Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In this review, we summarize existing literature on INSM1′ s reliability as an immunostain for detection of various NETs, its results in comparison to first-generation NET biomarkers, and its expression in both non-NETs and benign tissues/cells on cytology specimens (cell blocks/smears).

AB - Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In this review, we summarize existing literature on INSM1′ s reliability as an immunostain for detection of various NETs, its results in comparison to first-generation NET biomarkers, and its expression in both non-NETs and benign tissues/cells on cytology specimens (cell blocks/smears).

KW - Carcinoid

KW - Cytology

KW - INSM-1 immunostaining

KW - Medullary thyroid carcinoma

KW - Neuroendocrine tumor

KW - Pancreatic neuroendocrine tumor

KW - Pulmonary neuroendocrine neoplasms

U2 - 10.3390/diagnostics11122172

DO - 10.3390/diagnostics11122172

M3 - Review Article

AN - SCOPUS:85120070472

SN - 2075-4418

VL - 11

JO - Diagnostics

JF - Diagnostics

IS - 12

M1 - 2172

ER -

INSM1, a novel biomarker for detection of neuroendocrine neoplasms: Cytopathologists’ view

Abstrakti

Rahoitus

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

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Siteeraa tätä