Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study

Leena Hakola; Lazarus K. Mramba; Ulla Uusitalo; Carin Andrén Aronsson; Sandra Hummel; Sari Niinistö; Iris Erlund; Jimin Yang; Marian J. Rewers; Beena Akolkar; Richard A. McIndoe; Stephen S. Rich; William A. Hagopian; Anette Ziegler; Åke Lernmark; Jorma Toppari; Jeffrey P. Krischer; Jill M. Norris; Suvi M. Virtanen; TEDDY Study Group

doi:10.1007/s00394-024-03346-6

Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study

Leena Hakola^*
, Lazarus K. Mramba
, Ulla Uusitalo
, Carin Andrén Aronsson
, Sandra Hummel
, Sari Niinistö
, Iris Erlund
, Jimin Yang
, Marian J. Rewers
, Beena Akolkar
, Richard A. McIndoe
, Stephen S. Rich
, William A. Hagopian
, Anette Ziegler
, Åke Lernmark
, Jorma Toppari
, Jeffrey P. Krischer
, Jill M. Norris
, Suvi M. Virtanen
, TEDDY Study Group

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

9 Sitaatiot (Scopus)

26 Lataukset (Pure)

Abstrakti

Purpose : The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years. Methods: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country. Results: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes “any IA” and progression from IA to T1D. Conclusion: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.

Alkuperäiskieli	Englanti
Sivut	1329-1338
Sivumäärä	10
Julkaisu	European Journal of Nutrition
Vuosikerta	63
Varhainen verkossa julkaisun päivämäärä	2024
DOI - pysyväislinkit	https://doi.org/10.1007/s00394-024-03346-6
Tila	Julkaistu - 2024
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

Open access funding provided by Tampere University (including Tampere University Hospital). The TEDDY Study is funded by U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483, U01 DK124166, U01 DK128847, and Contract No. HHSN267200700014C from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Environmental Health Sciences (NIEHS), Centers for Disease Control and Prevention (CDC), and JDRF. This work is supported in part by the NIH/NCATS Clinical and Translational Science Awards to the University of Florida (UL1 TR000064) and the University of Colorado (UL1 TR002535). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. In addition, writing this paper was supported by Juho Vainio Foundation and Academy of Finland (339922). Supporting sources had no involvement or restrictions regarding publication.

Rahoittajat	Rahoittajan numero
National Institutes of Health
Centers for Disease Control and Prevention
National Institute of Allergy and Infectious Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Environmental Health Sciences
National Center for Advancing Translational Sciences
University of Florida	UL1 TR000064
Juvenile Diabetes Research Foundation United States of America
Eunice Kennedy Shriver National Institute of Child Health and Human Development
University of Colorado	UL1 TR002535
Academy of Finland	339922
Juho Vainion Säätiö

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 3 – Hyvä terveys ja hyvinvointi

Julkaisufoorumi-taso

Jufo-taso 2

!!ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

Pääsy asiakirjaan

10.1007/s00394-024-03346-6Lisenssi: CC BY

s00394-024-03346-6Final published version, 1,32 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202404123494Lisenssi: CC BY

Siteeraa tätä

Hakola, L., Mramba, L. K., Uusitalo, U., Andrén Aronsson, C., Hummel, S., Niinistö, S., Erlund, I., Yang, J., Rewers, M. J., Akolkar, B., McIndoe, R. A., Rich, S. S., Hagopian, W. A., Ziegler, A., Lernmark, Å., Toppari, J., Krischer, J. P., Norris, J. M., Virtanen, S. M., & TEDDY Study Group (2024). Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. European Journal of Nutrition, 63, 1329-1338. https://doi.org/10.1007/s00394-024-03346-6

@article{d7bea3e951214752ba1fc601fad35c16,

title = "Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study",

abstract = "Purpose : The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years. Methods: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country. Results: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9\%) developed multiple autoantibodies. 280 (3.3\%) children had IAA and 319 (3.8\%) GADA as the first autoantibody. 344 (44\%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95\% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95\% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95\% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95\% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes {\textquotedblleft}any IA{\textquotedblright} and progression from IA to T1D. Conclusion: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.",

keywords = "Birth cohort, Diabetes mellitus, type 1, Nutrient intake, Vitamin B complex",

author = "Leena Hakola and Mramba, \{Lazarus K.\} and Ulla Uusitalo and \{Andr{\'e}n Aronsson\}, Carin and Sandra Hummel and Sari Niinist{\"o} and Iris Erlund and Jimin Yang and Rewers, \{Marian J.\} and Beena Akolkar and McIndoe, \{Richard A.\} and Rich, \{Stephen S.\} and Hagopian, \{William A.\} and Anette Ziegler and {\AA}ke Lernmark and Jorma Toppari and Krischer, \{Jeffrey P.\} and Norris, \{Jill M.\} and Virtanen, \{Suvi M.\} and \{TEDDY Study Group\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

doi = "10.1007/s00394-024-03346-6",

language = "English",

volume = "63",

pages = "1329--1338",

journal = "European Journal of Nutrition",

issn = "1436-6207",

publisher = "Springer",

}

Hakola, L, Mramba, LK, Uusitalo, U, Andrén Aronsson, C, Hummel, S, Niinistö, S, Erlund, I, Yang, J, Rewers, MJ, Akolkar, B, McIndoe, RA, Rich, SS, Hagopian, WA, Ziegler, A, Lernmark, Å, Toppari, J, Krischer, JP, Norris, JM, Virtanen, SM & TEDDY Study Group 2024, 'Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study', European Journal of Nutrition, Vuosikerta 63, Sivut 1329-1338. https://doi.org/10.1007/s00394-024-03346-6

TY - JOUR

T1 - Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study

AU - Hakola, Leena

AU - Mramba, Lazarus K.

AU - Uusitalo, Ulla

AU - Andrén Aronsson, Carin

AU - Hummel, Sandra

AU - Niinistö, Sari

AU - Erlund, Iris

AU - Yang, Jimin

AU - Rewers, Marian J.

AU - Akolkar, Beena

AU - McIndoe, Richard A.

AU - Rich, Stephen S.

AU - Hagopian, William A.

AU - Ziegler, Anette

AU - Lernmark, Åke

AU - Toppari, Jorma

AU - Krischer, Jeffrey P.

AU - Norris, Jill M.

AU - Virtanen, Suvi M.

AU - TEDDY Study Group

PY - 2024

Y1 - 2024

N2 - Purpose : The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years. Methods: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country. Results: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes “any IA” and progression from IA to T1D. Conclusion: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.

AB - Purpose : The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years. Methods: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country. Results: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes “any IA” and progression from IA to T1D. Conclusion: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.

KW - Birth cohort

KW - Diabetes mellitus, type 1

KW - Nutrient intake

KW - Vitamin B complex

U2 - 10.1007/s00394-024-03346-6

DO - 10.1007/s00394-024-03346-6

M3 - Article

AN - SCOPUS:85186206593

SN - 1436-6207

VL - 63

SP - 1329

EP - 1338

JO - European Journal of Nutrition

JF - European Journal of Nutrition

ER -

Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study

Abstrakti

Rahoitus

YK:n kestävän kehityksen tavoitteet

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

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