TY - JOUR
T1 - L-cysteine augments the vasorelaxation induced by sodium nitrite and SIN-1 but not that due to acetylcholine
AU - Arvola, P
AU - Pörsti, I
AU - Vuorinen, P
AU - Huhtala, H
AU - Metsä-Ketelä, T
AU - Vapaatalo, H
PY - 1992/4/22
Y1 - 1992/4/22
N2 - The effects of 1 mM L-cysteine on sodium nitrite-, 3-morpholinosydnonimine (SIN-1)- and acetylcholine-induced relaxation and cyclic GMP accumulation were studied in isolated noradrenaline-precontracted rat mesenteric arterial rings. L-Cysteine augmented the relaxation and cyclic GMP increase induced by sodium nitrate and SIN-1 but not those induced by acetylcholine. The effects of L-cysteine on relaxation were independent of the presence of intact endothelium. The results suggest that L-cysteine protects exogenously released nitric oxide.
AB - The effects of 1 mM L-cysteine on sodium nitrite-, 3-morpholinosydnonimine (SIN-1)- and acetylcholine-induced relaxation and cyclic GMP accumulation were studied in isolated noradrenaline-precontracted rat mesenteric arterial rings. L-Cysteine augmented the relaxation and cyclic GMP increase induced by sodium nitrate and SIN-1 but not those induced by acetylcholine. The effects of L-cysteine on relaxation were independent of the presence of intact endothelium. The results suggest that L-cysteine protects exogenously released nitric oxide.
KW - Acetylcholine/administration & dosage
KW - Animals
KW - Cyclic GMP/metabolism
KW - Cysteine/administration & dosage
KW - Drug Synergism
KW - Endothelium, Vascular/drug effects
KW - In Vitro Techniques
KW - Male
KW - Mesenteric Arteries/drug effects
KW - Molsidomine/administration & dosage
KW - Nitric Oxide/metabolism
KW - Rats
KW - Rats, Inbred Strains
KW - Sodium Nitrite/administration & dosage
KW - Vasodilation/drug effects
U2 - 10.1016/0014-2999(92)90133-o
DO - 10.1016/0014-2999(92)90133-o
M3 - Article
C2 - 1325360
VL - 214
SP - 289
EP - 292
IS - 2-3
ER -