TY - JOUR
T1 - Machine Learning Heuristics on Gingivobuccal Cancer Gene Datasets Reveals Key Candidate Attributes for Prognosis
AU - Singh, Tanvi
AU - Malik, Girik
AU - Someshwar, Saloni
AU - Le, Hien Thi Thu
AU - Polavarapu, Rathnagiri
AU - Chavali, Laxmi N.
AU - Melethadathil, Nidheesh
AU - Sundararajan, Vijayaraghava Seshadri
AU - Valadi, Jayaraman
AU - Kavi Kishor, P. B.
AU - Suravajhala, Prashanth
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/12
Y1 - 2022/12
N2 - Delayed cancer detection is one of the common causes of poor prognosis in the case of many cancers, including cancers of the oral cavity. Despite the improvement and development of new and efficient gene therapy treatments, very little has been carried out to algorithmically assess the impedance of these carcinomas. In this work, from attributes or NCBI’s oral cancer datasets, viz. (i) name, (ii) gene(s), (iii) protein change, (iv) condition(s), clinical significance (last reviewed). We sought to train the number of instances emerging from them. Further, we attempt to annotate viable attributes in oral cancer gene datasets for the identification of gingivobuccal cancer (GBC). We further apply supervised and unsupervised machine learning methods to the gene datasets, revealing key candidate attributes for GBC prognosis. Our work highlights the importance of automated identification of key genes responsible for GBC that could perhaps be easily replicated in other forms of oral cancer detection.
AB - Delayed cancer detection is one of the common causes of poor prognosis in the case of many cancers, including cancers of the oral cavity. Despite the improvement and development of new and efficient gene therapy treatments, very little has been carried out to algorithmically assess the impedance of these carcinomas. In this work, from attributes or NCBI’s oral cancer datasets, viz. (i) name, (ii) gene(s), (iii) protein change, (iv) condition(s), clinical significance (last reviewed). We sought to train the number of instances emerging from them. Further, we attempt to annotate viable attributes in oral cancer gene datasets for the identification of gingivobuccal cancer (GBC). We further apply supervised and unsupervised machine learning methods to the gene datasets, revealing key candidate attributes for GBC prognosis. Our work highlights the importance of automated identification of key genes responsible for GBC that could perhaps be easily replicated in other forms of oral cancer detection.
KW - data mining
KW - gene prioritization
KW - genomic datasets
KW - machine learning
KW - oral cancer
U2 - 10.3390/genes13122379
DO - 10.3390/genes13122379
M3 - Article
C2 - 36553647
AN - SCOPUS:85144538805
SN - 2073-4425
VL - 13
JO - Genes
JF - Genes
IS - 12
M1 - 2379
ER -