Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search

Jeffrey R. Smith; Diha Freije; John D. Carpten; Henrik Grönberg; Jianfeng Xu; Sarah D. Isaacs; Michael J. Brownstein; G. Steven Bova; Hong Guo; Piroska Bujnovszky; Deborah R. Nusskern; Jan Erik Damber; Anders Bergh; Monika Emanuelsson; Olli P. Kallioniemi; Jennifer Walker-Daniels; Joan E. Bailey-Wilson; Terri H. Beaty; Deborah A. Meyers; Patrick C. Walsh; Francis S. Collins; Jeffrey M. Trent; William B. Isaacs

doi:10.1126/science.274.5291.1371

Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search

Jeffrey R. Smith
, Diha Freije
, John D. Carpten
, Henrik Grönberg
, Jianfeng Xu
, Sarah D. Isaacs
, Michael J. Brownstein
, G. Steven Bova
, Hong Guo
, Piroska Bujnovszky
, Deborah R. Nusskern
, Jan Erik Damber
, Anders Bergh
, Monika Emanuelsson
, Olli P. Kallioniemi
, Jennifer Walker-Daniels
, Joan E. Bailey-Wilson
, Terri H. Beaty
, Deborah A. Meyers
, Patrick C. Walsh

Francis S. Collins, Jeffrey M. Trent^*, William B. Isaacs

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

680 Sitaatiot (Scopus)

Abstrakti

Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high- risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.

Alkuperäiskieli	Englanti
Sivut	1371-1374
Sivumäärä	4
Julkaisu	Science
Vuosikerta	274
Numero	5291
DOI - pysyväislinkit	https://doi.org/10.1126/science.274.5291.1371
Tila	Julkaistu - 1996
Julkaistu ulkoisesti	Kyllä
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 3 – Hyvä terveys ja hyvinvointi

!!ASJC Scopus subject areas

General

Pääsy asiakirjaan

10.1126/science.274.5291.1371

Siteeraa tätä

Smith, J. R., Freije, D., Carpten, J. D., Grönberg, H., Xu, J., Isaacs, S. D., Brownstein, M. J., Bova, G. S., Guo, H., Bujnovszky, P., Nusskern, D. R., Damber, J. E., Bergh, A., Emanuelsson, M., Kallioniemi, O. P., Walker-Daniels, J., Bailey-Wilson, J. E., Beaty, T. H., Meyers, D. A., ... Isaacs, W. B. (1996). Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science, 274(5291), 1371-1374. https://doi.org/10.1126/science.274.5291.1371

@article{9ac6cd4fd0634dd5b14bbeb8eec41666,

title = "Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search",

abstract = "Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high- risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.",

author = "Smith, \{Jeffrey R.\} and Diha Freije and Carpten, \{John D.\} and Henrik Gr{\"o}nberg and Jianfeng Xu and Isaacs, \{Sarah D.\} and Brownstein, \{Michael J.\} and Bova, \{G. Steven\} and Hong Guo and Piroska Bujnovszky and Nusskern, \{Deborah R.\} and Damber, \{Jan Erik\} and Anders Bergh and Monika Emanuelsson and Kallioniemi, \{Olli P.\} and Jennifer Walker-Daniels and Bailey-Wilson, \{Joan E.\} and Beaty, \{Terri H.\} and Meyers, \{Deborah A.\} and Walsh, \{Patrick C.\} and Collins, \{Francis S.\} and Trent, \{Jeffrey M.\} and Isaacs, \{William B.\}",

year = "1996",

doi = "10.1126/science.274.5291.1371",

language = "English",

volume = "274",

pages = "1371--1374",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5291",

}

Smith, JR, Freije, D, Carpten, JD, Grönberg, H, Xu, J, Isaacs, SD, Brownstein, MJ, Bova, GS, Guo, H, Bujnovszky, P, Nusskern, DR, Damber, JE, Bergh, A, Emanuelsson, M, Kallioniemi, OP, Walker-Daniels, J, Bailey-Wilson, JE, Beaty, TH, Meyers, DA, Walsh, PC, Collins, FS, Trent, JM & Isaacs, WB 1996, 'Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search', Science, Vuosikerta 274, Nro 5291, Sivut 1371-1374. https://doi.org/10.1126/science.274.5291.1371

TY - JOUR

T1 - Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search

AU - Smith, Jeffrey R.

AU - Freije, Diha

AU - Carpten, John D.

AU - Grönberg, Henrik

AU - Xu, Jianfeng

AU - Isaacs, Sarah D.

AU - Brownstein, Michael J.

AU - Bova, G. Steven

AU - Guo, Hong

AU - Bujnovszky, Piroska

AU - Nusskern, Deborah R.

AU - Damber, Jan Erik

AU - Bergh, Anders

AU - Emanuelsson, Monika

AU - Kallioniemi, Olli P.

AU - Walker-Daniels, Jennifer

AU - Bailey-Wilson, Joan E.

AU - Beaty, Terri H.

AU - Meyers, Deborah A.

AU - Walsh, Patrick C.

AU - Collins, Francis S.

AU - Trent, Jeffrey M.

AU - Isaacs, William B.

PY - 1996

Y1 - 1996

N2 - Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high- risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.

AB - Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high- risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.

U2 - 10.1126/science.274.5291.1371

DO - 10.1126/science.274.5291.1371

M3 - Article

C2 - 8910276

AN - SCOPUS:0000009909

SN - 0036-8075

VL - 274

SP - 1371

EP - 1374

JO - Science

JF - Science

IS - 5291

ER -

Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search

Abstrakti

YK:n kestävän kehityksen tavoitteet

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

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