Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

Laura Aliisa Saarimäki; Antonio Federico; Iseult Lynch; Anastasios G. Papadiamantis; Andreas Tsoumanis; Georgia Melagraki; Antreas Afantitis; Angela Serra; Dario Greco

doi:10.1038/s41597-021-00808-y

Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

Laura Aliisa Saarimäki, Antonio Federico, Iseult Lynch, Anastasios G. Papadiamantis, Andreas Tsoumanis, Georgia Melagraki, Antreas Afantitis, Angela Serra, Dario Greco

Tutkimustuotos: Data-artikkeli › vertaisarvioitu

20 Sitaatiot (Scopus)

36 Lataukset (Pure)

Abstrakti

Toxicogenomics (TGx) approaches are increasingly applied to gain insight into the possible toxicity mechanisms of engineered nanomaterials (ENMs). Omics data can be valuable to elucidate the mechanism of action of chemicals and to develop predictive models in toxicology. While vast amounts of transcriptomics data from ENM exposures have already been accumulated, a unified, easily accessible and reusable collection of transcriptomics data for ENMs is currently lacking. In an attempt to improve the FAIRness of already existing transcriptomics data for ENMs, we curated a collection of homogenized transcriptomics data from human, mouse and rat ENM exposures in vitro and in vivo including the physicochemical characteristics of the ENMs used in each study.

Alkuperäiskieli	Englanti
Artikkeli	49
Julkaisu	Scientific Data
Vuosikerta	8
DOI - pysyväislinkit	https://doi.org/10.1038/s41597-021-00808-y
Tila	Julkaistu - 2021
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Statistics and Probability
Information Systems
Education
Computer Science Applications
Statistics, Probability and Uncertainty
Library and Information Sciences

Pääsy asiakirjaan

10.1038/s41597-021-00808-yLisenssi: CC BY

s41597-021-00808-yFinal published version, 1,55 MBLisenssi: CC BY

http://urn.fi/URN:NBN:fi:tuni-202105044358Lisenssi: CC BY

Metadata record for: Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials
Saarimäki, L. (Creator), Federico, A. (Contributor), Lynch, I. (Contributor), Papadiamantis, A. G. (Contributor), Tsoumanis, A. (Contributor), Melagraki, G. (Contributor), Afantitis, A. (Contributor), Serra, A. (Contributor) & Greco, D. (Contributor), 4 helmik. 2021
DOI - pysyväislinkki: 10.6084/m9.figshare.13154381.v1
Tietoaineisto: Dataset
Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials
Saarimäki, L. (Creator), Federico, A. (Creator), Lynch, I. (Creator), Papadiamantis, A. G. (Creator), Tsoumanis, A. (Creator), Melagraki, G. (Creator), Afantitis, A. (Creator), Serra, A. (Creator) & Greco, D. (Creator), 22 heinäk. 2020
DOI - pysyväislinkki: 10.5281/zenodo.6425445
Tietoaineisto: Dataset

Siteeraa tätä

@article{3c90d45ae7804f20b440ba44b0baf66b,

title = "Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials",

abstract = "Toxicogenomics (TGx) approaches are increasingly applied to gain insight into the possible toxicity mechanisms of engineered nanomaterials (ENMs). Omics data can be valuable to elucidate the mechanism of action of chemicals and to develop predictive models in toxicology. While vast amounts of transcriptomics data from ENM exposures have already been accumulated, a unified, easily accessible and reusable collection of transcriptomics data for ENMs is currently lacking. In an attempt to improve the FAIRness of already existing transcriptomics data for ENMs, we curated a collection of homogenized transcriptomics data from human, mouse and rat ENM exposures in vitro and in vivo including the physicochemical characteristics of the ENMs used in each study.",

author = "Saarim{\"a}ki, {Laura Aliisa} and Antonio Federico and Iseult Lynch and Papadiamantis, {Anastasios G.} and Andreas Tsoumanis and Georgia Melagraki and Antreas Afantitis and Angela Serra and Dario Greco",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

doi = "10.1038/s41597-021-00808-y",

language = "English",

volume = "8",

journal = "Scientific Data",

issn = "2052-4463",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

AU - Saarimäki, Laura Aliisa

AU - Federico, Antonio

AU - Lynch, Iseult

AU - Papadiamantis, Anastasios G.

AU - Tsoumanis, Andreas

AU - Melagraki, Georgia

AU - Afantitis, Antreas

AU - Serra, Angela

AU - Greco, Dario

PY - 2021

Y1 - 2021

N2 - Toxicogenomics (TGx) approaches are increasingly applied to gain insight into the possible toxicity mechanisms of engineered nanomaterials (ENMs). Omics data can be valuable to elucidate the mechanism of action of chemicals and to develop predictive models in toxicology. While vast amounts of transcriptomics data from ENM exposures have already been accumulated, a unified, easily accessible and reusable collection of transcriptomics data for ENMs is currently lacking. In an attempt to improve the FAIRness of already existing transcriptomics data for ENMs, we curated a collection of homogenized transcriptomics data from human, mouse and rat ENM exposures in vitro and in vivo including the physicochemical characteristics of the ENMs used in each study.

AB - Toxicogenomics (TGx) approaches are increasingly applied to gain insight into the possible toxicity mechanisms of engineered nanomaterials (ENMs). Omics data can be valuable to elucidate the mechanism of action of chemicals and to develop predictive models in toxicology. While vast amounts of transcriptomics data from ENM exposures have already been accumulated, a unified, easily accessible and reusable collection of transcriptomics data for ENMs is currently lacking. In an attempt to improve the FAIRness of already existing transcriptomics data for ENMs, we curated a collection of homogenized transcriptomics data from human, mouse and rat ENM exposures in vitro and in vivo including the physicochemical characteristics of the ENMs used in each study.

U2 - 10.1038/s41597-021-00808-y

DO - 10.1038/s41597-021-00808-y

M3 - Data article

C2 - 33558569

AN - SCOPUS:85101050795

SN - 2052-4463

VL - 8

JO - Scientific Data

JF - Scientific Data

M1 - 49

ER -

Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

Abstrakti

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

Tietoaineistot

Metadata record for: Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

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