Mechanosensitive Channel Piezo1 in R403Q Hypertrophic Cardiomyopathy: A Computational Study

Keyphrases

• Computational Study 100%
• Mechanosensitive Channel 100%
• Hypertrophic Cardiomyopathy 100%
• Piezo1 100%
• Mutation Specific 28%
• Mechanotransduction 28%
• Voltage-dependent Inactivation 28%
• Ca2+ 14%
• Putative Drug Targets 14%
• Human Induced Pluripotent Stem Cell-derived Cardiomyocytes (hiPSC-CMs) 14%
• In Silico 14%
• Ludwig Boltzmann 14%
• Inorganic Phosphate 14%
• Biophysical Model 14%
• Mechanistic Model 14%
• Myosin 14%
• Myofilament 14%
• Cation Channel 14%
• Hypertrophic Response 14%
• Normalized Current 14%
• Piezo1 Channel 14%
• Pressure Overload 14%
• Inactivation Gate 14%
• Whole-cell Model 14%

Biochemistry, Genetics and Molecular Biology

• Tension 100%
• Electric Potential 66%
• Mechanotransduction 66%
• Dynamics 33%
• Whole Cell 33%
• Cardiac Muscle Cell 33%
• Induced Pluripotent Stem Cell 33%

Medicine and Dentistry

• Hypertrophic Cardiomyopathy 100%
• Mechanotransduction 50%
• Cardiac Muscle Cell 25%
• In Silico 25%
• Induced Pluripotent Stem Cell 25%
• Calcium Ion 25%
• Myofilament 25%
• Cation Channel 25%
• Whole Cell 25%
• Phosphate 25%