Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues

Saara Marttila; Hely Tamminen; Sonja Rajić; Pashupati P Mishra; Terho Lehtimäki; Olli Raitakari; Mika Kähönen; Laura Kananen; Juulia Jylhävä; Sara Hägg; Thomas Delerue; Annette Peters; Melanie Waldenberger; Marcus E Kleber; Winfried März; Riitta Luoto; Jani Raitanen; Elina Sillanpää; Eija K Laakkonen; Aino Heikkinen; Miina Ollikainen; Emma Raitoharju

doi:10.2217/epi-2022-0228

Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues

Saara Marttila, Hely Tamminen, Sonja Rajić, Pashupati P Mishra, Terho Lehtimäki, Olli Raitakari, Mika Kähönen, Laura Kananen, Juulia Jylhävä, Sara Hägg, Thomas Delerue, Annette Peters, Melanie Waldenberger, Marcus E Kleber, Winfried März, Riitta Luoto, Jani Raitanen, Elina Sillanpää, Eija K Laakkonen, Aino HeikkinenMiina Ollikainen, Emma Raitoharju

Tutkimustuotos: Artikkeli › Scientific › vertaisarvioitu

Abstrakti

Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas ∼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.

Alkuperäiskieli	Englanti
Sivut	1105-1124
Julkaisu	Epigenomics
Vuosikerta	14
Numero	18
DOI - pysyväislinkit	https://doi.org/10.2217/epi-2022-0228
Tila	Julkaistu - lokak. 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

Jufo-taso 1

Pääsy asiakirjaan

10.2217/epi-2022-0228Lisenssi: CC BY

epi-2022-0228-1Final published version, 4,97 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202212099023Lisenssi: CC BY

Siteeraa tätä

Marttila, S., Tamminen, H., Rajić, S., Mishra, P. P., Lehtimäki, T., Raitakari, O., Kähönen, M., Kananen, L., Jylhävä, J., Hägg, S., Delerue, T., Peters, A., Waldenberger, M., Kleber, M. E., März, W., Luoto, R., Raitanen, J., Sillanpää, E., Laakkonen, E. K., ... Raitoharju, E. (2022). Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues. Epigenomics, 14(18), 1105-1124. https://doi.org/10.2217/epi-2022-0228

@article{cf3ee95328074c09a44ace14198004ed,

title = "Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues",

abstract = "Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas ∼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.",

author = "Saara Marttila and Hely Tamminen and Sonja Raji{\'c} and Mishra, {Pashupati P} and Terho Lehtim{\"a}ki and Olli Raitakari and Mika K{\"a}h{\"o}nen and Laura Kananen and Juulia Jylh{\"a}v{\"a} and Sara H{\"a}gg and Thomas Delerue and Annette Peters and Melanie Waldenberger and Kleber, {Marcus E} and Winfried M{\"a}rz and Riitta Luoto and Jani Raitanen and Elina Sillanp{\"a}{\"a} and Laakkonen, {Eija K} and Aino Heikkinen and Miina Ollikainen and Emma Raitoharju",

year = "2022",

month = oct,

doi = "10.2217/epi-2022-0228",

language = "English",

volume = "14",

pages = "1105--1124",

number = "18",

}

Marttila, S, Tamminen, H, Rajić, S, Mishra, PP , Lehtimäki, T, Raitakari, O, Kähönen, M , Kananen, L , Jylhävä, J, Hägg, S, Delerue, T, Peters, A, Waldenberger, M, Kleber, ME, März, W, Luoto, R, Raitanen, J, Sillanpää, E, Laakkonen, EK, Heikkinen, A, Ollikainen, M & Raitoharju, E 2022, 'Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues', Epigenomics, Vuosikerta 14, Nro 18, Sivut 1105-1124. https://doi.org/10.2217/epi-2022-0228

TY - JOUR

T1 - Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues

AU - Marttila, Saara

AU - Tamminen, Hely

AU - Rajić, Sonja

AU - Mishra, Pashupati P

AU - Lehtimäki, Terho

AU - Raitakari, Olli

AU - Kähönen, Mika

AU - Kananen, Laura

AU - Jylhävä, Juulia

AU - Hägg, Sara

AU - Delerue, Thomas

AU - Peters, Annette

AU - Waldenberger, Melanie

AU - Kleber, Marcus E

AU - März, Winfried

AU - Luoto, Riitta

AU - Raitanen, Jani

AU - Sillanpää, Elina

AU - Laakkonen, Eija K

AU - Heikkinen, Aino

AU - Ollikainen, Miina

AU - Raitoharju, Emma

PY - 2022/10

Y1 - 2022/10

N2 - Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas ∼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.

AB - Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas ∼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.

U2 - 10.2217/epi-2022-0228

DO - 10.2217/epi-2022-0228

M3 - Article

C2 - 36200237

VL - 14

SP - 1105

EP - 1124

IS - 18

ER -

Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues

Abstrakti

Julkaisufoorumi-taso

Pääsy asiakirjaan

Sormenjälki

Siteeraa tätä