Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D

Julkaisun otsikon käännös: Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D

    Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

    8 Sitaatiot (Scopus)
    33 Lataukset (Pure)

    Abstrakti

    We simulate the growth of neuronal networks using the two recently published tools, NETMORPH and CX3D. The goals of the work are (1) to examine and compare the simulation tools, (2) to construct a model of growth of neocortical cultures, and (3) to characterize the changes in network connectivity during growth, using standard graph theoretic methods. Parameters for the neocortical culture are chosen after consulting both the experimental and the computational work presented in the literature. The first (three) weeks in culture are known to be a time of development of extensive dendritic and axonal arbors and establishment of synaptic connections between the neurons. We simulate the growth of networks from day 1 to day 21. It is shown that for the properly selected parameters, the simulators can reproduce the experimentally obtained connectivity. The selected graph theoretic methods can capture the structural changes during growth.
    Julkaisun otsikon käännösModeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D
    AlkuperäiskieliEnglanti
    Artikkeli616382
    Sivut1-13
    Sivumäärä13
    JulkaisuEurasip Journal on Bioinformatics and Systems Biology
    Vuosikerta2011
    DOI - pysyväislinkit
    TilaJulkaistu - 2011
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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