TY - JOUR
T1 - Mortality and causes of death in different celiac disease phenotypes during long-term follow-up
AU - Koskinen, Inka
AU - Hervonen, Kaisa
AU - Huhtala, Heini
AU - Pasternack, Camilla
AU - Salmi, Teea
AU - Reunala, Timo
AU - Collin, Pekka
AU - Kaukinen, Katri
N1 - Funding Information:
This study was supported by grants to the Celiac Disease Study Group from the Sigrid Juselius Foundation, the Emil Aaltonen Foundation, the Academy of Finland, the Research Fund of the Finnish Coeliac Society, the Finnish Cultural Foundation and the Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022
Y1 - 2022
N2 - Background: Celiac disease has been associated with increased mortality, but data on long-term mortality are scarce. Aims: To determine long-term mortality in celiac disease. Methods: The study cohort consisted of all celiac disease patients (n=1,392) diagnosed in Tampere University Hospital catchment area 1960 – 2000. Patients were categorized into subgroups based on demographic (age, gender, decade of diagnosis) and celiac disease characteristics (e.g., phenotype, severity of villous atrophy) collected from medical records. Overall and cause-specific mortality was compared to those of age-, sex-, and place of residence matched reference individuals (n=4,177) over time. Results: During the 41 years of follow-up (median 26.5 years), 376 celiac disease patients and 1,155 reference individuals died. All-cause mortality was not increased (hazard ratio (HR) 0.96, 95% confidence intervals (CI) 0.85–1.08). Mortality from lymphoproliferative diseases and diseases of the central nervous system was increased (HR 2.42, 95% CI 1.38–4.24 and HR 2.14, 95% CI 1.05–4.36 respectively) while the risk from alcohol related diseases was decreased (HR 0.31, 95% CI 0.09–1.00). Examination of various celiac disease phenotypes revealed no significant differences in mortality Conclusions: Overall mortality was not increased in any celiac disease phenotype during a very long-term follow-up.
AB - Background: Celiac disease has been associated with increased mortality, but data on long-term mortality are scarce. Aims: To determine long-term mortality in celiac disease. Methods: The study cohort consisted of all celiac disease patients (n=1,392) diagnosed in Tampere University Hospital catchment area 1960 – 2000. Patients were categorized into subgroups based on demographic (age, gender, decade of diagnosis) and celiac disease characteristics (e.g., phenotype, severity of villous atrophy) collected from medical records. Overall and cause-specific mortality was compared to those of age-, sex-, and place of residence matched reference individuals (n=4,177) over time. Results: During the 41 years of follow-up (median 26.5 years), 376 celiac disease patients and 1,155 reference individuals died. All-cause mortality was not increased (hazard ratio (HR) 0.96, 95% confidence intervals (CI) 0.85–1.08). Mortality from lymphoproliferative diseases and diseases of the central nervous system was increased (HR 2.42, 95% CI 1.38–4.24 and HR 2.14, 95% CI 1.05–4.36 respectively) while the risk from alcohol related diseases was decreased (HR 0.31, 95% CI 0.09–1.00). Examination of various celiac disease phenotypes revealed no significant differences in mortality Conclusions: Overall mortality was not increased in any celiac disease phenotype during a very long-term follow-up.
KW - Celiac disease
KW - Long-term mortality
KW - Lymphoproliferative diseases
KW - Phenotype
U2 - 10.1016/j.dld.2022.04.016
DO - 10.1016/j.dld.2022.04.016
M3 - Article
AN - SCOPUS:85130397593
SN - 1590-8658
VL - 54
SP - 1502
EP - 1507
JO - DIGESTIVE AND LIVER DISEASE
JF - DIGESTIVE AND LIVER DISEASE
IS - 11
ER -