Myostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice

Julkaisun otsikon käännös: Myostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice

Heikki Kainulainen, Konstantinos G. Papaioannou, Mika Silvennoinen, Reija Autio, Janne Saarela, Bernardo M. Oliveira, Miro Nyqvist, Arja Pasternack, Peter A.C. ´t Hoen, Urho M. Kujala, Olli Ritvos, Juha J. Hulmi

    Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

    16 Sitaatiot (Scopus)

    Abstrakti

    Duchenne muscular dystrophy is characterized by muscle wasting and decreased aerobic metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in combination for 7 weeks in dystrophic mdx mice. Expression microarray analysis revealed decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice. This was not due to reduced home-cage physical activity, and was further downregulated upon sActRIIB-Fc treatment in enlarged muscles. However, exercise activated pathways of aerobic metabolism and counteracted the negative effects of sActRIIB-Fc. Exercise and sActRIIB-Fc synergistically increased expression of major urinary protein, but exercise blocked sActRIIB-Fc induced phosphorylation of STAT5 in gastrocnemius muscle. In conclusion, exercise alone or in combination with myostatin/activin blocking corrects aerobic gene expression profiles of dystrophic muscle toward healthy wild type mice profiles.
    Julkaisun otsikon käännösMyostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice
    AlkuperäiskieliEnglanti
    Sivut131-142
    Sivumäärä12
    JulkaisuMolecular and Cellular Endocrinology
    Vuosikerta399
    DOI - pysyväislinkit
    TilaJulkaistu - 2015
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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