Neuron–Glia Interactions and Brain Circuits

Tutkimustuotos: LukuScientificvertaisarvioitu

Abstrakti

Recent evidence suggests that glial cells take an active role in a number of brain functions that were previously attributed solely to neurons. For example, astrocytes, one type of glial cells, have been shown to promote coordinated activation of neuronal networks, modulate sensory-evoked neuronal network activity, and influence brain state transitions during development. This reinforces the idea that astrocytes not only provide the “housekeeping” for the neurons, but that they also play a vital role in supporting and expanding the functions of brain circuits and networks. Despite this accumulated knowledge, the field of computational neuroscience has mostly focused on modeling neuronal functions, ignoring the glial cells and the interactions they have with the neurons. In this chapter, we introduce the biology of neuron–glia interactions, summarize the existing computational models and tools, and emphasize the glial properties that may be important in modeling brain functions in the future.
AlkuperäiskieliEnglanti
OtsikkoComputational Modelling of the Brain
AlaotsikkoModelling Approaches to Cells, Circuits and Networks
ToimittajatMichele Giugliano, Mario Negrello, Daniele Linaro
KustantajaSpringer
Sivut87-103
Sivumäärä17
ISBN (elektroninen)978-3-030-89439-9
ISBN (painettu)978-3-030-89438-2
DOI - pysyväislinkit
TilaJulkaistu - 2022
OKM-julkaisutyyppiA3 Kirjan tai muun kokoomateoksen osa

Julkaisusarja

NimiAdvances in Experimental Medicine and Biology
Vuosikerta1359
ISSN (painettu)0065-2598
ISSN (elektroninen)0065-2598

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