Abstrakti
Hybrid scaffolds based on bioactive glass (BAG) particles (<38 µm), covalently linked to gelatin (G*) using 3-glycidoxypropyltrimethoxysilane (GPTMS), have been studied for bone bioen-gineering. In this study, two glass compositions (13-93 and 13-93B20 (where 20% of the SiO2 was replaced with B2O3)) were introduced in the gelatin matrix. The Cfactor (gelatin/GPTMS molar ratio) was kept constant at 500. The hybrids obtained were found to be stable at 37 °C in solution, the condition in which pure gelatin is liquid. All hybrids were characterized by in vitro dissolution in Tris(hydroxymethyl)aminomethane (TRIS) solution (for up to 4 weeks) and Simulated Body Fluid (SBF) (for up to 2 weeks). Samples processed with 13-93B20 exhibited faster initial dissolution and significantly faster precipitation of a hydroxyapatite (HA) layer. The faster ion release and HA precipitation recorded from the G*/13-93B20 samples are attributable to the higher reactivity of boro-silicate compared to silicate glass. The MC3T3-E1 cell behavior in direct contact with the hybrids was investigated, showing that the cells were able to proliferate and spread on the developed bio-materials. Tailoring the glass composition allows us to better control the material’s dissolution, bi-odegradability, and bioactivity. Bioactive (especially with 13-93B20 BAG) and biocompatible, the hybrids are promising for bone application.
Alkuperäiskieli | Englanti |
---|---|
Artikkeli | 444 |
Sivut | 1-16 |
Sivumäärä | 16 |
Julkaisu | Biomolecules |
Vuosikerta | 11 |
Numero | 3 |
DOI - pysyväislinkit | |
Tila | Julkaistu - maalisk. 2021 |
OKM-julkaisutyyppi | A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä |
Rahoitus
Funding: The authors thank Agence Nationale de la Recherche (ANR) INEX Paris Seine Initiative for the doctoral fellowship. Acknowledgments: The authors would like to thank the Science and Engineering Doctoral School of CY Cergy Paris Université for the financial support in researcher mobility.
Julkaisufoorumi-taso
- Jufo-taso 1
!!ASJC Scopus subject areas
- Biochemistry
- Molecular Biology