Nucleation threshold of carbon black ultrasound contrast agent

Craig S. Carlson, Ryunosuke Matsumoto, Koji Fushino, Miryu Shinzato, Nobuki Kudo, Michiel Postema

Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

1 Lataukset (Pure)

Abstrakti

Most ultrasound contrast agents used in ultrasonic imaging comprise shell-encapsulated microbubbles, whose ingredients have been associated with adverse bioeffects. In this study, we investigated the nucleation behaviour of carbon black dispersion, whose hydrophobic nanoparticles are used intradermally. For a hypothetical, perfectly spherical carbon black particle surrounded by a perfectly spherical gaseous void, we derived a theoretical nucleation threshold of only 1.3× the resting radius. Carbon black particles and aggregates thereof were investigated using high-speed photography during 1.0 MHz sonication. The nucleation threshold found experimentally is lower than the Blake cavitation threshold of 2.0 the resting radius of free, unencapsulated microbubbles. Therefore, carbon black dispersion may be a promising ultrasound contrast agent.
AlkuperäiskieliEnglanti
ArtikkeliSDDA06
JulkaisuJapanese Journal of Applied Physics
Vuosikerta60
NumeroSD
DOI - pysyväislinkit
TilaJulkaistu - 2021
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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