Occupational noise exposure and vestibular schwannoma: A case-control study in Sweden

Lisa Aarhus, Kristina Kjærheim, Sanna Heikkinen, Jan Ivar Martinsen, Eero Pukkala, Jenny Selander, Mattias Sjöström, Øivind Skare, Kurt Straif, Ingrid Sivesind Mehlum

Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

Abstrakti

It has been suggested that the association between self-reported occupational noise exposure and vestibular schwannoma (VS), found in several studies, represents recall bias. Therefore, we aimed to study the relationship in a large case-control study using occupational noise measurements. We performed a case-control study using data from Sweden for 1,913 VS cases diagnosed in 1961-2009 and 9,566 age- and sex-matched population controls. We defined occupational history by linkage to national censuses from 1960, 1970, 1980, and 1990. We estimated occupational noise exposure for each case and control using a job-exposure matrix. There was no association between occupational noise exposure and VS. Among subjects assessed as ever exposed to occupational noise levels of ≥85 dB (214 cases and 1,142 controls), the odds ratio for VS per 5 years of exposure was 1.02 (95% confidence interval: 0.90, 1.17). Workers with noise levels of ≥85 dB for at least 15 years (5-year latency period), showed no increased risk of VS (odds ratio = 0.98, 95% confidence interval: 0.73, 1.31) compared with those who had never been exposed to noise levels of 75 dB or higher. In summary, our large study does not support an association between occupational noise exposure and VS.

AlkuperäiskieliEnglanti
Sivut1342-1347
Sivumäärä6
JulkaisuAmerican Journal of Epidemiology
Vuosikerta189
Numero11
DOI - pysyväislinkit
TilaJulkaistu - marrask. 2020
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

  • Jufo-taso 2

!!ASJC Scopus subject areas

  • Epidemiology

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