Openly available MEA dataset from hPSC-derived and rat cortical networks and associated data analysis pipeline

We introduce a comparative dataset (over 2 TB) of microelectrode array (MEA) recordings from human pluripotent stem cell (hPSC)-derived and rat embryonic cortical neurons [1,2]. The data include extracellularly recorded spontaneous activity during the functional development of these neuronal networks and pharmacological experiments at their mature stage. The
dataset is openly available for scientific community [2]. Furthermore, we developed a comprehensive analysis pipeline for MEA recordings. Our
pipeline includes efficient tools for the analysis of spikes (extracellular action potentials), single channel bursts (dense time series of spikes) and network bursts (bursts synchronously occurring in multiple electrodes) (see Figure 1). The part of the analysis code is published together with the dataset [2] to replicate the key scientific findings of the original publication [1].