Phenotype of genetic knockout strains in dimethylbenz(a)anthracene and 12-O-tetradecanoyl phorbol-13-acetate (DMBA-TPA) two-stage mouse skin cancer model - a scoping review protocol

Experimental two-stage skin cancer model induced by dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoyl phorbol-13-acetate (TPA) is an ideal model for exploring individual genes’influence on the tumor initiation and progression in mouse. The objective for this scoping review isto evaluate the outcome of all gene knockouts on papilloma formation in DMBA-TPA two-stageskin cancer model. Four databases (PubMed, Scopus, Web of Science and Google Scholar) will besearched, and two authors will select the studies and extract the data independently. The review willnarratively synthesize the currently available evidence on the topic and create a database on thephenotype of all tested gene knockout strains in the DMBA-TPA two-stage chemically induced skincancer model.