Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study

TEDDY Study Group, Markus Mattila, William Hagopian, Jorma Toppari, Åke Lernmark, Anette G. Ziegler, Marian Rewers, Jeffrey P. Krischer, Jill M. Norris, Suvi M. Virtanen, Iris Erlund, Hye-Seung Lee, Sari Niinistö, Ulla Uusitalo, Carin Andrén Aronsson, Sandra Hummel, Hemang Parikh, Stephen S. Rich

Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

5 Sitaatiot (Scopus)

Abstrakti

Aims/hypothesis

We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes.

Methods

We used a risk set sampled nested case–control design within an ongoing international multicentre observational study: The Environmental Determinants of Diabetes in the Young (TEDDY). The TEDDY study followed children with increased genetic risk from birth to endpoints of islet autoantibodies (350 cases, 974 controls) and type 1 diabetes (102 cases, 282 controls) in six clinical centres. Control participants were matched for family history of type 1 diabetes, clinical centre and sex. Plasma ascorbic acid concentration was measured at ages 6 and 12 months and then annually up to age 6 years. SNPs in vitamin C transport genes were genotyped using the ImmunoChip custom microarray. Comparisons were adjusted for HLA genotypes and for background population stratification.

Results

Childhood plasma ascorbic acid (mean ± SD 10.76 ± 3.54 mg/l in controls) was inversely associated with islet autoimmunity risk (adjusted OR 0.96 [95% CI 0.92, 0.99] per +1 mg/l), particularly islet autoimmunity, starting with insulin autoantibodies (OR 0.94 [95% CI 0.88, 0.99]), but not with type 1 diabetes risk (OR 0.93 [95% Cl 0.86, 1.02]). The SLC2A2 rs5400 SNP was associated with increased risk of type 1 diabetes (OR 1.77 [95% CI 1.12, 2.80]), independent of plasma ascorbic acid (OR 0.92 [95% CI 0.84, 1.00]).

Conclusions/interpretation

Higher plasma ascorbic acid levels may protect against islet autoimmunity in children genetically at risk for type 1 diabetes. Further studies are warranted to confirm these findings.
AlkuperäiskieliEnglanti
Sivut278-286
JulkaisuDIABETOLOGIA
Vuosikerta63
Numero2
Varhainen verkossa julkaisun päivämäärä2019
DOI - pysyväislinkit
TilaJulkaistu - 2020
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Tutkimusalat

  • Autoimmunity
  • Plasma ascorbic acid
  • SNP
  • Single nucleotide polymorphism
  • Transporter genes
  • Type 1 diabetes
  • Vitamin C

Julkaisufoorumi-taso

  • Jufo-taso 2

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