Plasma Kynurenine to Tryptophan Ratio Is Not Associated with Undernutrition in Adults but Reduced after Nutrition Intervention: Results from a Community-Based Study in Bangladesh

Md Amran Gazi; Md Abdullah Siddique; Md Ashraful Alam; Farzana Hossaini; Md Mehedi Hasan; Shah Mohammad Fahim; Barbie Zaman Wahid; Md Mamun Kabir; Subhasish Das; Mustafa Mahfuz; Tahmeed Ahmed

doi:10.3390/nu14091708

Plasma Kynurenine to Tryptophan Ratio Is Not Associated with Undernutrition in Adults but Reduced after Nutrition Intervention: Results from a Community-Based Study in Bangladesh

Md Amran Gazi
, Md Abdullah Siddique
, Md Ashraful Alam
, Farzana Hossaini
, Md Mehedi Hasan
, Shah Mohammad Fahim
, Barbie Zaman Wahid
, Md Mamun Kabir
, Subhasish Das
, Mustafa Mahfuz^*
, Tahmeed Ahmed

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

5 Sitaatiot (Scopus)

14 Lataukset (Pure)

Abstrakti

Infections and persistent immunological activation are linked to increased kynurenine (KYN) and the KYN-to-Tryptophan (TRP) or KT ratio and may be critical factors in undernutrition. We sought to determine the association between the KT ratio and adult malnutrition, as well as investigate if nutritional supplementation had any influence on the decrease of the KT ratio. A total of 525 undernourished adults aged 18–45 years were recruited and provided a nutrition intervention for 60 feeding days. TRP and KYN concentrations were determined from plasma samples using LC-MS/MS. At baseline, the median (interquartile range (IQR)) TRP, KYN and KT ratios were 24.1 (17.6, 34.3) µmol/L, 0.76 (0.53, 1.18) µmol/L and 30.9 (24.5, 41.7), respectively. Following intervention, the median (IQR) KYN and KT ratios were significantly reduced to 0.713 (0.46, 1.12) µmol/L and 27.5 (21.3, 35.8). The KT ratio was found to be inversely linked with adult BMI (coefficient: −0.09; 95% CI: −0.18, 0.004; p-value = 0.06) but not statistically significant. Additionally, Plasma CRP was correlated positively, while LRP1 was inversely correlated with the KT ratio. Our data suggest that in Bangladeshi adults, the KT ratio is not related to the pathophysiology of malnutrition but correlated with inflammatory and anti-inflammatory biomarkers, and the ratio can be reduced by a nutrition intervention.

Alkuperäiskieli	Englanti
Artikkeli	1708
Sivumäärä	10
Julkaisu	Nutrients
Vuosikerta	14
Numero	9
DOI - pysyväislinkit	https://doi.org/10.3390/nu14091708
Tila	Julkaistu - 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

Acknowledgments: The authors thank the participants of the BEED study as well as the field and laboratory staff at icddr,b for their valuable contributions. The icddr,b also gratefully acknowledges the following donors for their unrestrained support: The Government of the People’s Republic of Bangladesh; Global Affairs Canada (GAC), Canada; the Swedish International Development Cooperation Agency (Sida) and the Department for International Development, (UKAid). This research protocol was funded by the Bill and Melinda Gates Foundation. The funders had no role in the study design; in the collection, analysis and interpretation of data; in the preparation, review or approval of the manuscript and decision to submit the manuscript. This study was funded by the Bill and Melinda Gates Foundation. The investment ID was OPP1136751. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding: This study was funded by the Bill and Melinda Gates Foundation. The investment ID was OPP1136751. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 2 – Ei nälkää
SDG 3 – Hyvä terveys ja hyvinvointi

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

Pääsy asiakirjaan

10.3390/nu14091708Lisenssi: CC BY

nutrients-14-01708Final published version, 480 KBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202207055987Lisenssi: CC BY

Siteeraa tätä

Gazi, M. A., Siddique, M. A., Alam, M. A., Hossaini, F., Hasan, M. M., Fahim, S. M., Wahid, B. Z., Kabir, M. M., Das, S., Mahfuz, M., & Ahmed, T. (2022). Plasma Kynurenine to Tryptophan Ratio Is Not Associated with Undernutrition in Adults but Reduced after Nutrition Intervention: Results from a Community-Based Study in Bangladesh. Nutrients, 14(9), Artikkeli 1708. https://doi.org/10.3390/nu14091708

@article{899aaf37f8734e41bc28c75af637fd80,

title = "Plasma Kynurenine to Tryptophan Ratio Is Not Associated with Undernutrition in Adults but Reduced after Nutrition Intervention: Results from a Community-Based Study in Bangladesh",

abstract = "Infections and persistent immunological activation are linked to increased kynurenine (KYN) and the KYN-to-Tryptophan (TRP) or KT ratio and may be critical factors in undernutrition. We sought to determine the association between the KT ratio and adult malnutrition, as well as investigate if nutritional supplementation had any influence on the decrease of the KT ratio. A total of 525 undernourished adults aged 18–45 years were recruited and provided a nutrition intervention for 60 feeding days. TRP and KYN concentrations were determined from plasma samples using LC-MS/MS. At baseline, the median (interquartile range (IQR)) TRP, KYN and KT ratios were 24.1 (17.6, 34.3) µmol/L, 0.76 (0.53, 1.18) µmol/L and 30.9 (24.5, 41.7), respectively. Following intervention, the median (IQR) KYN and KT ratios were significantly reduced to 0.713 (0.46, 1.12) µmol/L and 27.5 (21.3, 35.8). The KT ratio was found to be inversely linked with adult BMI (coefficient: −0.09; 95\% CI: −0.18, 0.004; p-value = 0.06) but not statistically significant. Additionally, Plasma CRP was correlated positively, while LRP1 was inversely correlated with the KT ratio. Our data suggest that in Bangladeshi adults, the KT ratio is not related to the pathophysiology of malnutrition but correlated with inflammatory and anti-inflammatory biomarkers, and the ratio can be reduced by a nutrition intervention.",

keywords = "Bangladesh, BMI, environmental enteric dysfunction, KT ratio, kynurenine, tryptophan, undernutrition",

author = "Gazi, \{Md Amran\} and Siddique, \{Md Abdullah\} and Alam, \{Md Ashraful\} and Farzana Hossaini and Hasan, \{Md Mehedi\} and Fahim, \{Shah Mohammad\} and Wahid, \{Barbie Zaman\} and Kabir, \{Md Mamun\} and Subhasish Das and Mustafa Mahfuz and Tahmeed Ahmed",

note = "Funding Information: Acknowledgments: The authors thank the participants of the BEED study as well as the field and laboratory staff at icddr,b for their valuable contributions. The icddr,b also gratefully acknowledges the following donors for their unrestrained support: The Government of the People{\textquoteright}s Republic of Bangladesh; Global Affairs Canada (GAC), Canada; the Swedish International Development Cooperation Agency (Sida) and the Department for International Development, (UKAid). This research protocol was funded by the Bill and Melinda Gates Foundation. The funders had no role in the study design; in the collection, analysis and interpretation of data; in the preparation, review or approval of the manuscript and decision to submit the manuscript. Funding Information: This study was funded by the Bill and Melinda Gates Foundation. The investment ID was OPP1136751. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: Funding: This study was funded by the Bill and Melinda Gates Foundation. The investment ID was OPP1136751. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

doi = "10.3390/nu14091708",

language = "English",

volume = "14",

journal = "Nutrients",

issn = "2072-6643",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "9",

}

Gazi, MA, Siddique, MA, Alam, MA, Hossaini, F, Hasan, MM, Fahim, SM, Wahid, BZ, Kabir, MM, Das, S, Mahfuz, M & Ahmed, T 2022, 'Plasma Kynurenine to Tryptophan Ratio Is Not Associated with Undernutrition in Adults but Reduced after Nutrition Intervention: Results from a Community-Based Study in Bangladesh', Nutrients, Vuosikerta 14, Nro 9, 1708. https://doi.org/10.3390/nu14091708

TY - JOUR

T1 - Plasma Kynurenine to Tryptophan Ratio Is Not Associated with Undernutrition in Adults but Reduced after Nutrition Intervention

T2 - Results from a Community-Based Study in Bangladesh

AU - Gazi, Md Amran

AU - Siddique, Md Abdullah

AU - Alam, Md Ashraful

AU - Hossaini, Farzana

AU - Hasan, Md Mehedi

AU - Fahim, Shah Mohammad

AU - Wahid, Barbie Zaman

AU - Kabir, Md Mamun

AU - Das, Subhasish

AU - Mahfuz, Mustafa

AU - Ahmed, Tahmeed

N1 - Funding Information: Acknowledgments: The authors thank the participants of the BEED study as well as the field and laboratory staff at icddr,b for their valuable contributions. The icddr,b also gratefully acknowledges the following donors for their unrestrained support: The Government of the People’s Republic of Bangladesh; Global Affairs Canada (GAC), Canada; the Swedish International Development Cooperation Agency (Sida) and the Department for International Development, (UKAid). This research protocol was funded by the Bill and Melinda Gates Foundation. The funders had no role in the study design; in the collection, analysis and interpretation of data; in the preparation, review or approval of the manuscript and decision to submit the manuscript. Funding Information: This study was funded by the Bill and Melinda Gates Foundation. The investment ID was OPP1136751. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: Funding: This study was funded by the Bill and Melinda Gates Foundation. The investment ID was OPP1136751. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022

Y1 - 2022

N2 - Infections and persistent immunological activation are linked to increased kynurenine (KYN) and the KYN-to-Tryptophan (TRP) or KT ratio and may be critical factors in undernutrition. We sought to determine the association between the KT ratio and adult malnutrition, as well as investigate if nutritional supplementation had any influence on the decrease of the KT ratio. A total of 525 undernourished adults aged 18–45 years were recruited and provided a nutrition intervention for 60 feeding days. TRP and KYN concentrations were determined from plasma samples using LC-MS/MS. At baseline, the median (interquartile range (IQR)) TRP, KYN and KT ratios were 24.1 (17.6, 34.3) µmol/L, 0.76 (0.53, 1.18) µmol/L and 30.9 (24.5, 41.7), respectively. Following intervention, the median (IQR) KYN and KT ratios were significantly reduced to 0.713 (0.46, 1.12) µmol/L and 27.5 (21.3, 35.8). The KT ratio was found to be inversely linked with adult BMI (coefficient: −0.09; 95% CI: −0.18, 0.004; p-value = 0.06) but not statistically significant. Additionally, Plasma CRP was correlated positively, while LRP1 was inversely correlated with the KT ratio. Our data suggest that in Bangladeshi adults, the KT ratio is not related to the pathophysiology of malnutrition but correlated with inflammatory and anti-inflammatory biomarkers, and the ratio can be reduced by a nutrition intervention.

AB - Infections and persistent immunological activation are linked to increased kynurenine (KYN) and the KYN-to-Tryptophan (TRP) or KT ratio and may be critical factors in undernutrition. We sought to determine the association between the KT ratio and adult malnutrition, as well as investigate if nutritional supplementation had any influence on the decrease of the KT ratio. A total of 525 undernourished adults aged 18–45 years were recruited and provided a nutrition intervention for 60 feeding days. TRP and KYN concentrations were determined from plasma samples using LC-MS/MS. At baseline, the median (interquartile range (IQR)) TRP, KYN and KT ratios were 24.1 (17.6, 34.3) µmol/L, 0.76 (0.53, 1.18) µmol/L and 30.9 (24.5, 41.7), respectively. Following intervention, the median (IQR) KYN and KT ratios were significantly reduced to 0.713 (0.46, 1.12) µmol/L and 27.5 (21.3, 35.8). The KT ratio was found to be inversely linked with adult BMI (coefficient: −0.09; 95% CI: −0.18, 0.004; p-value = 0.06) but not statistically significant. Additionally, Plasma CRP was correlated positively, while LRP1 was inversely correlated with the KT ratio. Our data suggest that in Bangladeshi adults, the KT ratio is not related to the pathophysiology of malnutrition but correlated with inflammatory and anti-inflammatory biomarkers, and the ratio can be reduced by a nutrition intervention.

KW - Bangladesh

KW - BMI

KW - environmental enteric dysfunction

KW - KT ratio

KW - kynurenine

KW - tryptophan

KW - undernutrition

U2 - 10.3390/nu14091708

DO - 10.3390/nu14091708

M3 - Article

AN - SCOPUS:85128572441

SN - 2072-6643

VL - 14

JO - Nutrients

JF - Nutrients

IS - 9

M1 - 1708

ER -

Plasma Kynurenine to Tryptophan Ratio Is Not Associated with Undernutrition in Adults but Reduced after Nutrition Intervention: Results from a Community-Based Study in Bangladesh

Abstrakti

Rahoitus

YK:n kestävän kehityksen tavoitteet

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

Siteeraa tätä