TY - JOUR
T1 - Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms
AU - Noerman, Stefania
AU - Klåvus, Anton
AU - Järvelä-Reijonen, Elina
AU - Karhunen, Leila
AU - Auriola, Seppo
AU - Korpela, Riitta
AU - Lappalainen, Raimo
AU - Kujala, Urho M.
AU - Puttonen, Sampsa
AU - Kolehmainen, Marjukka
AU - Hanhineva, Kati
N1 - Funding Information:
We appreciate the following financial supports: SalWe Research Program for Mind and Body (Tekes – the Finnish Funding Agency for Technology and Innovation grant 1104/10) for funding Elixir study; Kuopio University Hospital (VTR 510RA17) and Finnish Cultural Foundation (65171618 and 00180775) to SN; Academy of Finland to KH (277986, 283454, 305396) and LK (286028); Biocentre Finland and Biocentre Kuopio for supporting our LC-MS laboratory facility. The funders had no contribution in study design, data collection, data analysis, preparation of the manuscript, or decision to publish. We also thank Eeva Lajunen for managing the samples collection and storage, laboratory technician Miia Reponen for running the samples in LC-MS instrument, and Tero Myllymäki from Firstbeat Technologies for technical advice about the HRV-based measurement in the wearable devices.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/2/7
Y1 - 2020/2/7
N2 - Psychological stress is a suggested risk factor of metabolic disorders, but molecular mediators are not well understood. We investigated the association between the metabolic profiles of fasting plasma and the improvement of psychological well-being using non-targeted liquid chromatography-mass spectrometry (LC-MS) platform. The metabolic profiles of volunteers participating in the face-to-face intervention group (n = 60) in a randomised lifestyle intervention were compared to ones of controls (n = 64) between baseline and 36-week follow-up. Despite modest differences in metabolic profile between groups, we found associations between phosphatidylcholines (PCs) and several parameters indicating stress, adiposity, relaxation, and recovery. The relief of heart-rate-variability-based stress had positive, while improved indices of recovery and relaxation in the intervention group had an inverse association with the reduction of e.g. lysophosphatidylcholines (LPC). Interleukin-1 receptor antagonist and adiposity correlated positively with the suppressed PCs and negatively with the elevated plasmalogens PC(P-18:0/22:6) and PC(P-18:0/20:4). Also, we found changes in an unknown class of lipids over time regardless of the intervention groups, which also correlated with physiological and psychological markers of stress. The associations between lipid changes with some markers of psychological wellbeing and body composition may suggest the involvement of these lipids in the shared mechanisms between psychological and metabolic health.
AB - Psychological stress is a suggested risk factor of metabolic disorders, but molecular mediators are not well understood. We investigated the association between the metabolic profiles of fasting plasma and the improvement of psychological well-being using non-targeted liquid chromatography-mass spectrometry (LC-MS) platform. The metabolic profiles of volunteers participating in the face-to-face intervention group (n = 60) in a randomised lifestyle intervention were compared to ones of controls (n = 64) between baseline and 36-week follow-up. Despite modest differences in metabolic profile between groups, we found associations between phosphatidylcholines (PCs) and several parameters indicating stress, adiposity, relaxation, and recovery. The relief of heart-rate-variability-based stress had positive, while improved indices of recovery and relaxation in the intervention group had an inverse association with the reduction of e.g. lysophosphatidylcholines (LPC). Interleukin-1 receptor antagonist and adiposity correlated positively with the suppressed PCs and negatively with the elevated plasmalogens PC(P-18:0/22:6) and PC(P-18:0/20:4). Also, we found changes in an unknown class of lipids over time regardless of the intervention groups, which also correlated with physiological and psychological markers of stress. The associations between lipid changes with some markers of psychological wellbeing and body composition may suggest the involvement of these lipids in the shared mechanisms between psychological and metabolic health.
U2 - 10.1038/s41598-020-59051-x
DO - 10.1038/s41598-020-59051-x
M3 - Article
C2 - 32034255
AN - SCOPUS:85079084561
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 2143
ER -
