Preferences for albumin use in adult intensive care unit patients with shock: An international survey

Praleene Sivapalan; Karen Louise Ellekjaer; Anders Perner; Morten Hylander Møller; Anders Granholm; Lasse Grønningsæter; Marlies Ostermann; Rob Mac Sweeney; Maria Cronhjort; Johanna Hästbacka; Carmen Pfortmueller; Jan De Waele; Marek Nalos; Tomas Jovaisa; Annika Reintam Blaser; Maurizio Cecconi; Begum Ergan; Abdulrahman Al-Fares; Paul J. Young; Wojciech Szczeklik; Eric Keus; Fayez Alshamsi; Ashish K. Khanna; Martin Ingi Sigurdsson; Tomoko Fujii; Yaseen M. Arabi; Tine Sylvest Meyhoff

doi:10.1111/aas.14479

Preferences for albumin use in adult intensive care unit patients with shock: An international survey

Praleene Sivapalan^*
, Karen Louise Ellekjaer
, Anders Perner
, Morten Hylander Møller
, Anders Granholm
, Lasse Grønningsæter
, Marlies Ostermann
, Rob Mac Sweeney
, Maria Cronhjort
, Johanna Hästbacka
, Carmen Pfortmueller
, Jan De Waele
, Marek Nalos
, Tomas Jovaisa
, Annika Reintam Blaser
, Maurizio Cecconi
, Begum Ergan
, Abdulrahman Al-Fares
, Paul J. Young
, Wojciech Szczeklik

Eric Keus, Fayez Alshamsi, Ashish K. Khanna, Martin Ingi Sigurdsson, Tomoko Fujii, Yaseen M. Arabi, Tine Sylvest Meyhoff

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

8 Sitaatiot (Scopus)

15 Lataukset (Pure)

Abstrakti

Introduction: Use of albumin is suggested for some patients with shock, but preferences for its use may vary among intensive care unit (ICU) physicians. Methods: We conducted an international online survey of ICU physicians with 20 questions about their use of albumin and their opinion towards a randomised trial among adults with shock comparing the use versus no use of albumin. Results: A total of 1248 respondents participated, with a mean response rate of 37%, ranging from 18% to 75% across 21 countries. Respondents mainly worked in mixed ICUs and 92% were specialists in intensive care medicine. The reported use of albumin in general shock varied as 18% reported ‘almost never’, 22% ‘rarely’, 34% ‘occasionally’, 22% ‘frequently’ and 4% ‘almost always’ using albumin. In septic shock, 19% reported ‘almost never’, 22% ‘rarely’, 29% ‘occasionally’, 22% ‘frequently’ and 7% ‘almost always’ using albumin. Physicians’ preferences were more consistent for haemorrhagic- and cardiogenic shock, with more than 45% reporting ‘almost never’ using albumin. While the reported use of albumin for other purposes than resuscitation was infrequent (40%–85% reported ‘almost never’ for five other indications), the most frequent other indications were low serum albumin levels and improvement of the efficacy of diuretics. Most respondents (93%) would randomise adult ICU patients with shock to a trial of albumin versus no albumin. Conclusions: In this international survey, the reported preferences for the use of albumin in adult ICU patients with shock varied considerably among surveyed ICU physicians. The support for a future randomised trial was high.

Alkuperäiskieli	Englanti
Sivut	1234-1243
Julkaisu	Acta Anaesthesiologica Scandinavica
Vuosikerta	68
Numero	9
Varhainen verkossa julkaisun päivämäärä	2024
DOI - pysyväislinkit	https://doi.org/10.1111/aas.14479
Tila	Julkaistu - 2024
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

PS, KLE, AP, MHM, AG and TM are involved in the design of a domain on the Intensive Care Platform Trial (INCEPT, www.incept.dk ) investigating the use of albumin. INCEPT is funded by Sygeforsikringen \u2018danmark\u2019 and the Novo Nordisk Foundation and supported by Grosserer Jakob Ehrenreich and Hustru Grete Ehrenreich Foundation, Dagmar Marshalls Foundation and Savv\u00E6rksejer Jeppe Juhl and Ovita Juhls Mindelegat. PS, KLE, AP, MHM, AG and TM are affiliated with the Department of Intensive Care at Rigshospitalet, which has received funding for other projects from the Novo Nordisk Foundation. PS received funding from the Research Council of Rigshospitalet and Jakob Ehrenreich and his wife Grete Ehrenreich's Foundation. AP has received an honorarium from Novartis for participation in an advisory board. JDW has consulted for Menarini, MSD, Pfizer, ThermoFisher and Viatris with fees and honoraria paid to institution. JH has received an honorarium from Paion for participation in an advisory board. ARB received speaker or consultancy fees from Nutricia Danone and VIPUN Medical and she is holding a grant from the Estonian Research Council. AK currently consults for or has consulted for Medtronic, Edwards Life Sciences, Philips Research North America, Baxter, GE Healthcare, Potrero Medical, Fifth Eye Inc., Retia Medical, Caretaker Medical, Renibus Therapeutics, Trevena Pharmaceuticals and Pharmazz Inc. AK is also a member of the Surviving Sepsis Guidelines Research Committee, SCCM ESICM joint task force on Norepinephrine formulations and Chairs the SCCMM Discovery Research Network. The remaining authors declare no conflicts of interest. The funders had no influence on the design, conduct or the decision to publish the results of this manuscript.

Rahoittajat
Dagmar Marshalls Fond
VIPUN Medical
Grosserer Jakob Ehrenreich og Hustru Grete Ehrenreichs Fond
Savvaerksejer Jeppe Juhl og Hustru Ovita Juhls Mindelegat
Eesti Teadusagentuur
Novo Nordisk Fonden

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Anesthesiology and Pain Medicine

Pääsy asiakirjaan

10.1111/aas.14479Lisenssi: CC BY-NC-ND

Preferences for albumin use in adult intensive care unit patients with shock Final published version, 1,69 MBLisenssi: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-202408138097Lisenssi: CC BY-NC-ND

Siteeraa tätä

Sivapalan, P., Ellekjaer, K. L., Perner, A., Møller, M. H., Granholm, A., Grønningsæter, L., Ostermann, M., Sweeney, R. M., Cronhjort, M., Hästbacka, J., Pfortmueller, C., De Waele, J., Nalos, M., Jovaisa, T., Reintam Blaser, A., Cecconi, M., Ergan, B., Al-Fares, A., Young, P. J., ... Meyhoff, T. S. (2024). Preferences for albumin use in adult intensive care unit patients with shock: An international survey. Acta Anaesthesiologica Scandinavica, 68(9), 1234-1243. https://doi.org/10.1111/aas.14479

@article{e4a432dcb7454e6a899c533dabfcda3e,

title = "Preferences for albumin use in adult intensive care unit patients with shock: An international survey",

abstract = "Introduction: Use of albumin is suggested for some patients with shock, but preferences for its use may vary among intensive care unit (ICU) physicians. Methods: We conducted an international online survey of ICU physicians with 20 questions about their use of albumin and their opinion towards a randomised trial among adults with shock comparing the use versus no use of albumin. Results: A total of 1248 respondents participated, with a mean response rate of 37\%, ranging from 18\% to 75\% across 21 countries. Respondents mainly worked in mixed ICUs and 92\% were specialists in intensive care medicine. The reported use of albumin in general shock varied as 18\% reported {\textquoteleft}almost never{\textquoteright}, 22\% {\textquoteleft}rarely{\textquoteright}, 34\% {\textquoteleft}occasionally{\textquoteright}, 22\% {\textquoteleft}frequently{\textquoteright} and 4\% {\textquoteleft}almost always{\textquoteright} using albumin. In septic shock, 19\% reported {\textquoteleft}almost never{\textquoteright}, 22\% {\textquoteleft}rarely{\textquoteright}, 29\% {\textquoteleft}occasionally{\textquoteright}, 22\% {\textquoteleft}frequently{\textquoteright} and 7\% {\textquoteleft}almost always{\textquoteright} using albumin. Physicians{\textquoteright} preferences were more consistent for haemorrhagic- and cardiogenic shock, with more than 45\% reporting {\textquoteleft}almost never{\textquoteright} using albumin. While the reported use of albumin for other purposes than resuscitation was infrequent (40\%–85\% reported {\textquoteleft}almost never{\textquoteright} for five other indications), the most frequent other indications were low serum albumin levels and improvement of the efficacy of diuretics. Most respondents (93\%) would randomise adult ICU patients with shock to a trial of albumin versus no albumin. Conclusions: In this international survey, the reported preferences for the use of albumin in adult ICU patients with shock varied considerably among surveyed ICU physicians. The support for a future randomised trial was high.",

keywords = "albumin, fluid therapy, intensive care unit, shock, survey",

author = "Praleene Sivapalan and Ellekjaer, \{Karen Louise\} and Anders Perner and M{\o}ller, \{Morten Hylander\} and Anders Granholm and Lasse Gr{\o}nnings{\ae}ter and Marlies Ostermann and Sweeney, \{Rob Mac\} and Maria Cronhjort and Johanna H{\"a}stbacka and Carmen Pfortmueller and \{De Waele\}, Jan and Marek Nalos and Tomas Jovaisa and \{Reintam Blaser\}, Annika and Maurizio Cecconi and Begum Ergan and Abdulrahman Al-Fares and Young, \{Paul J.\} and Wojciech Szczeklik and Eric Keus and Fayez Alshamsi and Khanna, \{Ashish K.\} and Sigurdsson, \{Martin Ingi\} and Tomoko Fujii and Arabi, \{Yaseen M.\} and Meyhoff, \{Tine Sylvest\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley \& Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.",

year = "2024",

doi = "10.1111/aas.14479",

language = "English",

volume = "68",

pages = "1234--1243",

journal = "Acta Anaesthesiologica Scandinavica",

issn = "0001-5172",

publisher = "Blackwell Munksgaard",

number = "9",

}

Sivapalan, P, Ellekjaer, KL, Perner, A, Møller, MH, Granholm, A, Grønningsæter, L, Ostermann, M, Sweeney, RM, Cronhjort, M, Hästbacka, J, Pfortmueller, C, De Waele, J, Nalos, M, Jovaisa, T, Reintam Blaser, A, Cecconi, M, Ergan, B, Al-Fares, A, Young, PJ, Szczeklik, W, Keus, E, Alshamsi, F, Khanna, AK, Sigurdsson, MI, Fujii, T, Arabi, YM & Meyhoff, TS 2024, 'Preferences for albumin use in adult intensive care unit patients with shock: An international survey', Acta Anaesthesiologica Scandinavica, Vuosikerta 68, Nro 9, Sivut 1234-1243. https://doi.org/10.1111/aas.14479

TY - JOUR

T1 - Preferences for albumin use in adult intensive care unit patients with shock

T2 - An international survey

AU - Sivapalan, Praleene

AU - Ellekjaer, Karen Louise

AU - Perner, Anders

AU - Møller, Morten Hylander

AU - Granholm, Anders

AU - Grønningsæter, Lasse

AU - Ostermann, Marlies

AU - Sweeney, Rob Mac

AU - Cronhjort, Maria

AU - Hästbacka, Johanna

AU - Pfortmueller, Carmen

AU - De Waele, Jan

AU - Nalos, Marek

AU - Jovaisa, Tomas

AU - Reintam Blaser, Annika

AU - Cecconi, Maurizio

AU - Ergan, Begum

AU - Al-Fares, Abdulrahman

AU - Young, Paul J.

AU - Szczeklik, Wojciech

AU - Keus, Eric

AU - Alshamsi, Fayez

AU - Khanna, Ashish K.

AU - Sigurdsson, Martin Ingi

AU - Fujii, Tomoko

AU - Arabi, Yaseen M.

AU - Meyhoff, Tine Sylvest

PY - 2024

Y1 - 2024

N2 - Introduction: Use of albumin is suggested for some patients with shock, but preferences for its use may vary among intensive care unit (ICU) physicians. Methods: We conducted an international online survey of ICU physicians with 20 questions about their use of albumin and their opinion towards a randomised trial among adults with shock comparing the use versus no use of albumin. Results: A total of 1248 respondents participated, with a mean response rate of 37%, ranging from 18% to 75% across 21 countries. Respondents mainly worked in mixed ICUs and 92% were specialists in intensive care medicine. The reported use of albumin in general shock varied as 18% reported ‘almost never’, 22% ‘rarely’, 34% ‘occasionally’, 22% ‘frequently’ and 4% ‘almost always’ using albumin. In septic shock, 19% reported ‘almost never’, 22% ‘rarely’, 29% ‘occasionally’, 22% ‘frequently’ and 7% ‘almost always’ using albumin. Physicians’ preferences were more consistent for haemorrhagic- and cardiogenic shock, with more than 45% reporting ‘almost never’ using albumin. While the reported use of albumin for other purposes than resuscitation was infrequent (40%–85% reported ‘almost never’ for five other indications), the most frequent other indications were low serum albumin levels and improvement of the efficacy of diuretics. Most respondents (93%) would randomise adult ICU patients with shock to a trial of albumin versus no albumin. Conclusions: In this international survey, the reported preferences for the use of albumin in adult ICU patients with shock varied considerably among surveyed ICU physicians. The support for a future randomised trial was high.

AB - Introduction: Use of albumin is suggested for some patients with shock, but preferences for its use may vary among intensive care unit (ICU) physicians. Methods: We conducted an international online survey of ICU physicians with 20 questions about their use of albumin and their opinion towards a randomised trial among adults with shock comparing the use versus no use of albumin. Results: A total of 1248 respondents participated, with a mean response rate of 37%, ranging from 18% to 75% across 21 countries. Respondents mainly worked in mixed ICUs and 92% were specialists in intensive care medicine. The reported use of albumin in general shock varied as 18% reported ‘almost never’, 22% ‘rarely’, 34% ‘occasionally’, 22% ‘frequently’ and 4% ‘almost always’ using albumin. In septic shock, 19% reported ‘almost never’, 22% ‘rarely’, 29% ‘occasionally’, 22% ‘frequently’ and 7% ‘almost always’ using albumin. Physicians’ preferences were more consistent for haemorrhagic- and cardiogenic shock, with more than 45% reporting ‘almost never’ using albumin. While the reported use of albumin for other purposes than resuscitation was infrequent (40%–85% reported ‘almost never’ for five other indications), the most frequent other indications were low serum albumin levels and improvement of the efficacy of diuretics. Most respondents (93%) would randomise adult ICU patients with shock to a trial of albumin versus no albumin. Conclusions: In this international survey, the reported preferences for the use of albumin in adult ICU patients with shock varied considerably among surveyed ICU physicians. The support for a future randomised trial was high.

KW - albumin

KW - fluid therapy

KW - intensive care unit

KW - shock

KW - survey

U2 - 10.1111/aas.14479

DO - 10.1111/aas.14479

M3 - Article

AN - SCOPUS:85196676043

SN - 0001-5172

VL - 68

SP - 1234

EP - 1243

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

IS - 9

ER -

Preferences for albumin use in adult intensive care unit patients with shock: An international survey

Abstrakti

Rahoitus

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

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