Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy

Sara Sammallahti; Elisa Holmlund-Suila; Runyu Zou; Saara Valkama; Jenni Rosendahl; Maria Enlund-Cerullo; Helena Hauta-alus; Marius Lahti-Pulkkinen; Hanan El Marroun; Henning Tiemeier; Outi Mäkitie; Sture Andersson; Katri Räikkönen; Kati Heinonen

doi:10.1007/s00787-021-01894-4

Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy

Sara Sammallahti
, Elisa Holmlund-Suila
, Runyu Zou
, Saara Valkama
, Jenni Rosendahl
, Maria Enlund-Cerullo
, Helena Hauta-alus
, Marius Lahti-Pulkkinen
, Hanan El Marroun
, Henning Tiemeier
, Outi Mäkitie
, Sture Andersson
, Katri Räikkönen
, Kati Heinonen^*

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

10 Sitaatiot (Scopus)

12 Lataukset (Pure)

Abstrakti

Higher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopathology. We investigated if maternal early/mid-pregnancy 25-hydroxyvitamin D (25(OH)D) and neonatal cord blood 25(OH)D concentrations are associated with Negative affectivity in infancy. We studied term-born infants from the vitamin D Intervention in Infants study (VIDI, n = 777, follow-up rate 80%, Finland), and the Generation R Study (n = 1505, follow-up rate 40%, Netherlands). We measured maternal serum 25(OH)D at 6–27 weeks (VIDI) or 18–25 weeks (Generation R) of pregnancy, and cord blood 25(OH)D at birth (both cohorts). Caregivers rated infant Negative affectivity at 11.7 months (VIDI) or 6.5 months (Generation R) using the Revised Infant Behavior Questionnaire. Using linear regression, we tested associations between 25(OH)D and Negative affectivity adjusted for infant age, sex, season of 25(OH)D measurement, maternal age, education, smoking, and body-mass-index. Per 10 nmol/l increase in maternal early/mid-pregnancy 25(OH)D, infant Negative affectivity decreased by 0.02 standard deviations (95% confidence interval [CI] − 0.06, − 0.004) in VIDI, and 0.03 standard deviations (95% CI − 0.03, − 0.01) in Generation R. Cord blood 25(OH)D was associated with Negative affectivity in Generation R (− 0.03, 95% CI − 0.05, − 0.01), but not VIDI (0.00, 95% CI − 0.02, 0.02). Lower maternal 25(OH)D concentrations were consistently associated with higher infant Negative affectivity, while associations between cord blood 25(OH)D concentrations and Negative affectivity were less clear. Maternal vitamin D status during early- and mid-pregnancy may be linked with early-emerging differences in offspring behavior.

Alkuperäiskieli	Englanti
Sivut	601-609
Julkaisu	European Child and Adolescent Psychiatry
Vuosikerta	32
Numero	4
Varhainen verkossa julkaisun päivämäärä	18 lokak. 2021
DOI - pysyväislinkit	https://doi.org/10.1007/s00787-021-01894-4
Tila	Julkaistu - 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

The general design of the Generation R Study was supported by the Netherlands Organization for Scientific Research (NWO) and the Dutch Ministry of Health, Welfare, and Sport. The work of the authors involved in the Generation R Study in this project was supported by the LEaDing Fellows EU Marie Skłodowska-Curie COFUND Programme and the Orion Research Foundation (Dr Sammallahti); NWO Vici Grant 016.VICI.170.200 (Dr Tiemeier); and Stichting Volksbond Rotterdam, the Brain & Behavior Research Foundation NARSAD Young Investigator Grant 27853, and the European Union's Horizon 2020 Research and Innovation Program LifeCycle grant No. 733206 (Dr El Marroun). The work of the authors involved in the VIDI study in this project was supported by the Academy of Finland (Dr Heinonen [grant n:o 345057]; Dr Outi Mäkitie, and Dr Lahti-Pulkkinen), by the Sigrid Jusélius Foundation and the Novo Nordisk Foundation (Dr Outi Mäkitie), by the Päivikki and Sakari Sohlberg Foundation and the Juho Vainio Foundation (Dr Hauta-alus), by the Victoriastiftelsen, the Instrumentarium Science Foundation, the Paulo Foundation, and the Orion Research Foundation (Dr Enlund-Cerullo), and by Grants from Special Governmental Subsidy to Clinical Research, the Foundation for Pediatric Research in Finland, and Finska Läkaresällskapet (Dr Andersson). The funding sources had no role in study design, data collection and analysis, the interpretation or reporting of the results, or the decision to submit the manuscript for publication.

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 3 – Hyvä terveys ja hyvinvointi

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental and Educational Psychology
Psychiatry and Mental health

Pääsy asiakirjaan

10.1007/s00787-021-01894-4

Sammallahti2021_Article_PrenatalMaternalAndCordBloodViFinal published version, 1,15 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202111088246Lisenssi: CC BY

Siteeraa tätä

Sammallahti, S., Holmlund-Suila, E., Zou, R., Valkama, S., Rosendahl, J., Enlund-Cerullo, M., Hauta-alus, H., Lahti-Pulkkinen, M., El Marroun, H., Tiemeier, H., Mäkitie, O., Andersson, S., Räikkönen, K., & Heinonen, K. (2023). Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy. European Child and Adolescent Psychiatry, 32(4), 601-609. https://doi.org/10.1007/s00787-021-01894-4

@article{86252e7a9edb424d938ac6ca10befb7c,

title = "Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy",

abstract = "Higher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopathology. We investigated if maternal early/mid-pregnancy 25-hydroxyvitamin D (25(OH)D) and neonatal cord blood 25(OH)D concentrations are associated with Negative affectivity in infancy. We studied term-born infants from the vitamin D Intervention in Infants study (VIDI, n = 777, follow-up rate 80\%, Finland), and the Generation R Study (n = 1505, follow-up rate 40\%, Netherlands). We measured maternal serum 25(OH)D at 6{\textendash}27 weeks (VIDI) or 18{\textendash}25 weeks (Generation R) of pregnancy, and cord blood 25(OH)D at birth (both cohorts). Caregivers rated infant Negative affectivity at 11.7 months (VIDI) or 6.5 months (Generation R) using the Revised Infant Behavior Questionnaire. Using linear regression, we tested associations between 25(OH)D and Negative affectivity adjusted for infant age, sex, season of 25(OH)D measurement, maternal age, education, smoking, and body-mass-index. Per 10 nmol/l increase in maternal early/mid-pregnancy 25(OH)D, infant Negative affectivity decreased by 0.02 standard deviations (95\% confidence interval [CI] − 0.06, − 0.004) in VIDI, and 0.03 standard deviations (95\% CI − 0.03, − 0.01) in Generation R. Cord blood 25(OH)D was associated with Negative affectivity in Generation R (− 0.03, 95\% CI − 0.05, − 0.01), but not VIDI (0.00, 95\% CI − 0.02, 0.02). Lower maternal 25(OH)D concentrations were consistently associated with higher infant Negative affectivity, while associations between cord blood 25(OH)D concentrations and Negative affectivity were less clear. Maternal vitamin D status during early- and mid-pregnancy may be linked with early-emerging differences in offspring behavior.",

keywords = "Infant mental health, Negative affectivity, Nutrition, Prenatal, Temperament, Vitamin D",

author = "Sara Sammallahti and Elisa Holmlund-Suila and Runyu Zou and Saara Valkama and Jenni Rosendahl and Maria Enlund-Cerullo and Helena Hauta-alus and Marius Lahti-Pulkkinen and \{El Marroun\}, Hanan and Henning Tiemeier and Outi M{\"a}kitie and Sture Andersson and Katri R{\"a}ikk{\"o}nen and Kati Heinonen",

note = "Funding Information: The general design of the Generation R Study was supported by the Netherlands Organization for Scientific Research (NWO) and the Dutch Ministry of Health, Welfare, and Sport. The work of the authors involved in the Generation R Study in this project was supported by the LEaDing Fellows EU Marie Sk{\l}odowska-Curie COFUND Programme and the Orion Research Foundation (Dr Sammallahti); NWO Vici Grant 016.VICI.170.200 (Dr Tiemeier); and Stichting Volksbond Rotterdam, the Brain \& Behavior Research Foundation NARSAD Young Investigator Grant 27853, and the European Union's Horizon 2020 Research and Innovation Program LifeCycle grant No. 733206 (Dr El Marroun). The work of the authors involved in the VIDI study in this project was supported by the Academy of Finland (Dr Heinonen [grant n:o 345057]; Dr Outi M{\"a}kitie, and Dr Lahti-Pulkkinen), by the Sigrid Jus{\'e}lius Foundation and the Novo Nordisk Foundation (Dr Outi M{\"a}kitie), by the P{\"a}ivikki and Sakari Sohlberg Foundation and the Juho Vainio Foundation (Dr Hauta-alus), by the Victoriastiftelsen, the Instrumentarium Science Foundation, the Paulo Foundation, and the Orion Research Foundation (Dr Enlund-Cerullo), and by Grants from Special Governmental Subsidy to Clinical Research, the Foundation for Pediatric Research in Finland, and Finska L{\"a}kares{\"a}llskapet (Dr Andersson). The funding sources had no role in study design, data collection and analysis, the interpretation or reporting of the results, or the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2023",

doi = "10.1007/s00787-021-01894-4",

language = "English",

volume = "32",

pages = "601--609",

journal = "European Child and Adolescent Psychiatry",

issn = "1018-8827",

publisher = "Springer",

number = "4",

}

Sammallahti, S, Holmlund-Suila, E, Zou, R, Valkama, S, Rosendahl, J, Enlund-Cerullo, M, Hauta-alus, H, Lahti-Pulkkinen, M, El Marroun, H, Tiemeier, H, Mäkitie, O, Andersson, S, Räikkönen, K & Heinonen, K 2023, 'Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy', European Child and Adolescent Psychiatry, Vuosikerta 32, Nro 4, Sivut 601-609. https://doi.org/10.1007/s00787-021-01894-4

TY - JOUR

T1 - Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy

AU - Sammallahti, Sara

AU - Holmlund-Suila, Elisa

AU - Zou, Runyu

AU - Valkama, Saara

AU - Rosendahl, Jenni

AU - Enlund-Cerullo, Maria

AU - Hauta-alus, Helena

AU - Lahti-Pulkkinen, Marius

AU - El Marroun, Hanan

AU - Tiemeier, Henning

AU - Mäkitie, Outi

AU - Andersson, Sture

AU - Räikkönen, Katri

AU - Heinonen, Kati

N1 - Funding Information: The general design of the Generation R Study was supported by the Netherlands Organization for Scientific Research (NWO) and the Dutch Ministry of Health, Welfare, and Sport. The work of the authors involved in the Generation R Study in this project was supported by the LEaDing Fellows EU Marie Skłodowska-Curie COFUND Programme and the Orion Research Foundation (Dr Sammallahti); NWO Vici Grant 016.VICI.170.200 (Dr Tiemeier); and Stichting Volksbond Rotterdam, the Brain & Behavior Research Foundation NARSAD Young Investigator Grant 27853, and the European Union's Horizon 2020 Research and Innovation Program LifeCycle grant No. 733206 (Dr El Marroun). The work of the authors involved in the VIDI study in this project was supported by the Academy of Finland (Dr Heinonen [grant n:o 345057]; Dr Outi Mäkitie, and Dr Lahti-Pulkkinen), by the Sigrid Jusélius Foundation and the Novo Nordisk Foundation (Dr Outi Mäkitie), by the Päivikki and Sakari Sohlberg Foundation and the Juho Vainio Foundation (Dr Hauta-alus), by the Victoriastiftelsen, the Instrumentarium Science Foundation, the Paulo Foundation, and the Orion Research Foundation (Dr Enlund-Cerullo), and by Grants from Special Governmental Subsidy to Clinical Research, the Foundation for Pediatric Research in Finland, and Finska Läkaresällskapet (Dr Andersson). The funding sources had no role in study design, data collection and analysis, the interpretation or reporting of the results, or the decision to submit the manuscript for publication. Publisher Copyright: © 2021, The Author(s).

PY - 2023

Y1 - 2023

N2 - Higher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopathology. We investigated if maternal early/mid-pregnancy 25-hydroxyvitamin D (25(OH)D) and neonatal cord blood 25(OH)D concentrations are associated with Negative affectivity in infancy. We studied term-born infants from the vitamin D Intervention in Infants study (VIDI, n = 777, follow-up rate 80%, Finland), and the Generation R Study (n = 1505, follow-up rate 40%, Netherlands). We measured maternal serum 25(OH)D at 6–27 weeks (VIDI) or 18–25 weeks (Generation R) of pregnancy, and cord blood 25(OH)D at birth (both cohorts). Caregivers rated infant Negative affectivity at 11.7 months (VIDI) or 6.5 months (Generation R) using the Revised Infant Behavior Questionnaire. Using linear regression, we tested associations between 25(OH)D and Negative affectivity adjusted for infant age, sex, season of 25(OH)D measurement, maternal age, education, smoking, and body-mass-index. Per 10 nmol/l increase in maternal early/mid-pregnancy 25(OH)D, infant Negative affectivity decreased by 0.02 standard deviations (95% confidence interval [CI] − 0.06, − 0.004) in VIDI, and 0.03 standard deviations (95% CI − 0.03, − 0.01) in Generation R. Cord blood 25(OH)D was associated with Negative affectivity in Generation R (− 0.03, 95% CI − 0.05, − 0.01), but not VIDI (0.00, 95% CI − 0.02, 0.02). Lower maternal 25(OH)D concentrations were consistently associated with higher infant Negative affectivity, while associations between cord blood 25(OH)D concentrations and Negative affectivity were less clear. Maternal vitamin D status during early- and mid-pregnancy may be linked with early-emerging differences in offspring behavior.

AB - Higher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopathology. We investigated if maternal early/mid-pregnancy 25-hydroxyvitamin D (25(OH)D) and neonatal cord blood 25(OH)D concentrations are associated with Negative affectivity in infancy. We studied term-born infants from the vitamin D Intervention in Infants study (VIDI, n = 777, follow-up rate 80%, Finland), and the Generation R Study (n = 1505, follow-up rate 40%, Netherlands). We measured maternal serum 25(OH)D at 6–27 weeks (VIDI) or 18–25 weeks (Generation R) of pregnancy, and cord blood 25(OH)D at birth (both cohorts). Caregivers rated infant Negative affectivity at 11.7 months (VIDI) or 6.5 months (Generation R) using the Revised Infant Behavior Questionnaire. Using linear regression, we tested associations between 25(OH)D and Negative affectivity adjusted for infant age, sex, season of 25(OH)D measurement, maternal age, education, smoking, and body-mass-index. Per 10 nmol/l increase in maternal early/mid-pregnancy 25(OH)D, infant Negative affectivity decreased by 0.02 standard deviations (95% confidence interval [CI] − 0.06, − 0.004) in VIDI, and 0.03 standard deviations (95% CI − 0.03, − 0.01) in Generation R. Cord blood 25(OH)D was associated with Negative affectivity in Generation R (− 0.03, 95% CI − 0.05, − 0.01), but not VIDI (0.00, 95% CI − 0.02, 0.02). Lower maternal 25(OH)D concentrations were consistently associated with higher infant Negative affectivity, while associations between cord blood 25(OH)D concentrations and Negative affectivity were less clear. Maternal vitamin D status during early- and mid-pregnancy may be linked with early-emerging differences in offspring behavior.

KW - Infant mental health

KW - Negative affectivity

KW - Nutrition

KW - Prenatal

KW - Temperament

KW - Vitamin D

U2 - 10.1007/s00787-021-01894-4

DO - 10.1007/s00787-021-01894-4

M3 - Article

AN - SCOPUS:85117710746

SN - 1018-8827

VL - 32

SP - 601

EP - 609

JO - European Child and Adolescent Psychiatry

JF - European Child and Adolescent Psychiatry

IS - 4

ER -

Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy

Abstrakti

Rahoitus

YK:n kestävän kehityksen tavoitteet

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

Siteeraa tätä