Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound

Craig S. Carlson, Nicole Anderton, Antje Pohl, Andrew J. Smith, Nobuki Kudo, Michiel Postema

Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

Abstrakti

Controlled tablet disintegration is useful for chemical consistency checks. This study monitored the swelling of 54 analgesia tablets from two different batches, during 13-6-MHz brightness-mode sonication and simultaneous video recording. The tablets were placed on an acoustic reflector inside a container and sonicated from the top. Sonication shortened the displacement half-life by 17%-27%. During tablet swelling, their speed of sound increased linearly, confirming the linearity of this process. Diagnostic ultrasound significantly decreased tablet disintegration times, supporting the ultrasound-microbubble interaction hypothesis.
AlkuperäiskieliEnglanti
ArtikkeliSG1030
JulkaisuJapanese Journal of Applied Physics
Vuosikerta61
NumeroSG
DOI - pysyväislinkit
TilaJulkaistu - 2022
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

  • Jufo-taso 1

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