Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound

Craig S. Carlson, Nicole Anderton, Antje Pohl, Andrew J. Smith, Nobuki Kudo, Michiel Postema

    Tutkimustuotos: ArtikkeliTieteellinenvertaisarvioitu

    2 Sitaatiot (Scopus)
    7 Lataukset (Pure)

    Abstrakti

    Controlled tablet disintegration is useful for chemical consistency checks. This study monitored the swelling of 54 analgesia tablets from two different batches, during 13-6-MHz brightness-mode sonication and simultaneous video recording. The tablets were placed on an acoustic reflector inside a container and sonicated from the top. Sonication shortened the displacement half-life by 17%-27%. During tablet swelling, their speed of sound increased linearly, confirming the linearity of this process. Diagnostic ultrasound significantly decreased tablet disintegration times, supporting the ultrasound-microbubble interaction hypothesis.
    AlkuperäiskieliEnglanti
    ArtikkeliSG1030
    JulkaisuJapanese Journal of Applied Physics
    Vuosikerta61
    NumeroSG
    DOI - pysyväislinkit
    TilaJulkaistu - 2022
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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