Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk: A stop diabetes pragmatic randomised trial

Timo A. Lakka; Kirsikka Aittola; Elina Järvelä-Reijonen; Tanja Tilles-Tirkkonen; Reija Männikkö; Niina Lintu; Leila Karhunen; Marjukka Kolehmainen; Marja Harjumaa; Elina M. Mattila; Riia Järvenpää; Miikka J Ermes; Santtu Mikkonen; Janne Martikainen; Kaisa Poutanen; Ursula Schwab; Pilvikki Absetz; Jaana Lindström; Jussi Pihlajamäki

doi:10.1016/j.lanepe.2022.100527

Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk: A stop diabetes pragmatic randomised trial

Timo A. Lakka, Kirsikka Aittola, Elina Järvelä-Reijonen, Tanja Tilles-Tirkkonen, Reija Männikkö, Niina Lintu, Leila Karhunen, Marjukka Kolehmainen, Marja Harjumaa, Elina M. Mattila, Riia Järvenpää, Miikka J Ermes, Santtu Mikkonen, Janne Martikainen, Kaisa Poutanen, Ursula Schwab, Pilvikki Absetz, Jaana Lindström, Jussi Pihlajamäki

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Tutkimustuotos: Artikkeli › Scientific › vertaisarvioitu

Abstrakti

Background: No real-world randomised controlled trials (RCTs) have explored the effectiveness of lifestyle interventions based on multiple behaviour change theories and using combined digital and group-based face-to-face delivery to improve risk factors for type 2 diabetes (T2D). Methods: We conducted a one-year, multi-centre, unblinded, pragmatic RCT in primary healthcare using the habit formation, self-determination, and self-regulation theories among 2907 adults aged 18–74 years at increased T2D risk randomised into a digital lifestyle intervention group (DIGI, n = 967), a combined digital and group-based lifestyle intervention group (DIGI+GROUP, n = 971), and a control group receiving usual care (CONTROL, n = 969). We collected data on primary outcomes (diet quality by Healthy Diet Index [HDI], physical activity, body weight, fasting plasma glucose, 2-hour plasma glucose) and secondary outcomes (sedentary time, waist circumference, fasting plasma insulin) using digital questionnaires, clinical examinations, fasting blood tests, and 2-hour oral glucose tolerance tests. Main statistical analyses were performed using linear mixed-effects models adjusted for age, sex, and province. This RCT was registered with ClinicalTrials.gov, NCT03156478. Findings: The 2907 participants assigned were recruited between March 1st, 2017, and February 28th, 2018. Diet quality improved more (3·2 vs. 1·4 HDI points, p

Alkuperäiskieli	Englanti
Artikkeli	100527
Sivumäärä	13
Julkaisu	The Lancet Regional Health - Europe
Vuosikerta	24
Varhainen verkossa julkaisun päivämäärä	12 lokak. 2022
DOI - pysyväislinkit	https://doi.org/10.1016/j.lanepe.2022.100527
Tila	Julkaistu - tammik. 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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10.1016/j.lanepe.2022.100527Lisenssi: CC BY-NC-ND

1-s2.0-S266677622200223X-mainFinal published version, 820 KBLisenssi: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-202304254358Lisenssi: CC BY-NC-ND

Siteeraa tätä

Lakka, T. A., Aittola, K., Järvelä-Reijonen, E., Tilles-Tirkkonen, T., Männikkö, R., Lintu, N., Karhunen, L., Kolehmainen, M., Harjumaa, M., Mattila, E. M., Järvenpää, R., Ermes, M. J., Mikkonen, S., Martikainen, J., Poutanen, K., Schwab, U., Absetz, P., Lindström, J., & Pihlajamäki, J. (2023). Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk: A stop diabetes pragmatic randomised trial. The Lancet Regional Health - Europe, 24, [100527]. https://doi.org/10.1016/j.lanepe.2022.100527

@article{f3c8f7f9ddbd4ff99699f855d2942979,

title = "Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk: A stop diabetes pragmatic randomised trial",

abstract = "Background: No real-world randomised controlled trials (RCTs) have explored the effectiveness of lifestyle interventions based on multiple behaviour change theories and using combined digital and group-based face-to-face delivery to improve risk factors for type 2 diabetes (T2D). Methods: We conducted a one-year, multi-centre, unblinded, pragmatic RCT in primary healthcare using the habit formation, self-determination, and self-regulation theories among 2907 adults aged 18–74 years at increased T2D risk randomised into a digital lifestyle intervention group (DIGI, n = 967), a combined digital and group-based lifestyle intervention group (DIGI+GROUP, n = 971), and a control group receiving usual care (CONTROL, n = 969). We collected data on primary outcomes (diet quality by Healthy Diet Index [HDI], physical activity, body weight, fasting plasma glucose, 2-hour plasma glucose) and secondary outcomes (sedentary time, waist circumference, fasting plasma insulin) using digital questionnaires, clinical examinations, fasting blood tests, and 2-hour oral glucose tolerance tests. Main statistical analyses were performed using linear mixed-effects models adjusted for age, sex, and province. This RCT was registered with ClinicalTrials.gov, NCT03156478. Findings: The 2907 participants assigned were recruited between March 1st, 2017, and February 28th, 2018. Diet quality improved more (3·2 vs. 1·4 HDI points, p",

author = "Lakka, {Timo A.} and Kirsikka Aittola and Elina J{\"a}rvel{\"a}-Reijonen and Tanja Tilles-Tirkkonen and Reija M{\"a}nnikk{\"o} and Niina Lintu and Leila Karhunen and Marjukka Kolehmainen and Marja Harjumaa and Mattila, {Elina M.} and Riia J{\"a}rvenp{\"a}{\"a} and Ermes, {Miikka J} and Santtu Mikkonen and Janne Martikainen and Kaisa Poutanen and Ursula Schwab and Pilvikki Absetz and Jaana Lindstr{\"o}m and Jussi Pihlajam{\"a}ki",

year = "2023",

month = jan,

doi = "10.1016/j.lanepe.2022.100527",

language = "English",

volume = "24",

}

Lakka, TA, Aittola, K, Järvelä-Reijonen, E, Tilles-Tirkkonen, T, Männikkö, R, Lintu, N, Karhunen, L, Kolehmainen, M, Harjumaa, M, Mattila, EM, Järvenpää, R, Ermes, MJ, Mikkonen, S, Martikainen, J, Poutanen, K, Schwab, U, Absetz, P, Lindström, J & Pihlajamäki, J 2023, 'Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk: A stop diabetes pragmatic randomised trial', The Lancet Regional Health - Europe, Vuosikerta 24, 100527. https://doi.org/10.1016/j.lanepe.2022.100527

Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk: A stop diabetes pragmatic randomised trial. / Lakka, Timo A.; Aittola, Kirsikka; Järvelä-Reijonen, Elina et al.
julkaisussa: The Lancet Regional Health - Europe, Vuosikerta 24, 100527, 01.2023.

Tutkimustuotos: Artikkeli › Scientific › vertaisarvioitu

TY - JOUR

T1 - Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk

T2 - A stop diabetes pragmatic randomised trial

AU - Lakka, Timo A.

AU - Aittola, Kirsikka

AU - Järvelä-Reijonen, Elina

AU - Tilles-Tirkkonen, Tanja

AU - Männikkö, Reija

AU - Lintu, Niina

AU - Karhunen, Leila

AU - Kolehmainen, Marjukka

AU - Harjumaa, Marja

AU - Mattila, Elina M.

AU - Järvenpää, Riia

AU - Ermes, Miikka J

AU - Mikkonen, Santtu

AU - Martikainen, Janne

AU - Poutanen, Kaisa

AU - Schwab, Ursula

AU - Absetz, Pilvikki

AU - Lindström, Jaana

AU - Pihlajamäki, Jussi

PY - 2023/1

Y1 - 2023/1

N2 - Background: No real-world randomised controlled trials (RCTs) have explored the effectiveness of lifestyle interventions based on multiple behaviour change theories and using combined digital and group-based face-to-face delivery to improve risk factors for type 2 diabetes (T2D). Methods: We conducted a one-year, multi-centre, unblinded, pragmatic RCT in primary healthcare using the habit formation, self-determination, and self-regulation theories among 2907 adults aged 18–74 years at increased T2D risk randomised into a digital lifestyle intervention group (DIGI, n = 967), a combined digital and group-based lifestyle intervention group (DIGI+GROUP, n = 971), and a control group receiving usual care (CONTROL, n = 969). We collected data on primary outcomes (diet quality by Healthy Diet Index [HDI], physical activity, body weight, fasting plasma glucose, 2-hour plasma glucose) and secondary outcomes (sedentary time, waist circumference, fasting plasma insulin) using digital questionnaires, clinical examinations, fasting blood tests, and 2-hour oral glucose tolerance tests. Main statistical analyses were performed using linear mixed-effects models adjusted for age, sex, and province. This RCT was registered with ClinicalTrials.gov, NCT03156478. Findings: The 2907 participants assigned were recruited between March 1st, 2017, and February 28th, 2018. Diet quality improved more (3·2 vs. 1·4 HDI points, p

AB - Background: No real-world randomised controlled trials (RCTs) have explored the effectiveness of lifestyle interventions based on multiple behaviour change theories and using combined digital and group-based face-to-face delivery to improve risk factors for type 2 diabetes (T2D). Methods: We conducted a one-year, multi-centre, unblinded, pragmatic RCT in primary healthcare using the habit formation, self-determination, and self-regulation theories among 2907 adults aged 18–74 years at increased T2D risk randomised into a digital lifestyle intervention group (DIGI, n = 967), a combined digital and group-based lifestyle intervention group (DIGI+GROUP, n = 971), and a control group receiving usual care (CONTROL, n = 969). We collected data on primary outcomes (diet quality by Healthy Diet Index [HDI], physical activity, body weight, fasting plasma glucose, 2-hour plasma glucose) and secondary outcomes (sedentary time, waist circumference, fasting plasma insulin) using digital questionnaires, clinical examinations, fasting blood tests, and 2-hour oral glucose tolerance tests. Main statistical analyses were performed using linear mixed-effects models adjusted for age, sex, and province. This RCT was registered with ClinicalTrials.gov, NCT03156478. Findings: The 2907 participants assigned were recruited between March 1st, 2017, and February 28th, 2018. Diet quality improved more (3·2 vs. 1·4 HDI points, p

U2 - 10.1016/j.lanepe.2022.100527

DO - 10.1016/j.lanepe.2022.100527

M3 - Article

VL - 24

M1 - 100527

ER -

Lakka TA, Aittola K, Järvelä-Reijonen E, Tilles-Tirkkonen T, Männikkö R, Lintu N et al. Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk: A stop diabetes pragmatic randomised trial. The Lancet Regional Health - Europe. 2023 tammi;24:100527. Epub 2022 loka 12. doi: 10.1016/j.lanepe.2022.100527

Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk: A stop diabetes pragmatic randomised trial

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