Resistance Training Increases White Matter Density in Frail Elderly Women

Marco Bucci; Patricia Iozzo; Harri Merisaari; Ville Huovinen; Heta Lipponen; Katri Räikkönen; Riitta Parkkola; Minna Salonen; Samuel Sandboge; Johan Gunnar Eriksson; Lauri Nummenmaa; Pirjo Nuutila

doi:10.3390/jcm12072684

Resistance Training Increases White Matter Density in Frail Elderly Women

Marco Bucci^*
, Patricia Iozzo
, Harri Merisaari
, Ville Huovinen
, Heta Lipponen
, Katri Räikkönen
, Riitta Parkkola
, Minna Salonen
, Samuel Sandboge
, Johan Gunnar Eriksson
, Lauri Nummenmaa
, Pirjo Nuutila

^*Tämän työn vastaava kirjoittaja

Hyvinvointitieteet

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

5 Sitaatiot (Scopus)

11 Lataukset (Pure)

Abstrakti

We aimed to investigate the effects of maternal obesity on brain structure and metabolism in frail women, and their reversibility in response to exercise. We recruited 37 frail elderly women (20 offspring of lean/normal-weight mothers (OLM) and 17 offspring of obese/overweight mothers (OOM)) and nine non-frail controls to undergo magnetic resonance and diffusion tensor imaging (DTI), positron emission tomography with Fluorine-18-fluorodeoxyglucose (PET), and cognitive function tests (CERAD). Frail women were studied before and after a 4-month resistance training, and controls were studied once. White matter (WM) density (voxel-based morphometry) was higher in OLM than in OOM subjects. Exercise increased WM density in both OLM and OOM in the cerebellum in superior parietal regions in OLM and in cuneal and precuneal regions in OOM. OLM gained more WM density than OOM in response to intervention. No significant results were found from the Freesurfer analysis, nor from PET or DTI images. Exercise has an impact on brain morphology and cognition in elderly frail women.

Alkuperäiskieli	Englanti
Artikkeli	2684
Julkaisu	Journal of Clinical Medicine
Vuosikerta	12
Numero	7
DOI - pysyväislinkit	https://doi.org/10.3390/jcm12072684
Tila	Julkaistu - huhtik. 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

This study was supported by grants and funding from the DORIAN EU FP7 (DORIAN–Developmental ORIgins of healthy and unhealthy AgeiNg: The role of maternal obesity, project number 278603), the Academy of Finland, the Finnish Cultural Foundation, the South-Western Finland Cultural Foundation and the Turku University Foundation. Study was conducted within the Centre of Excellence in Cardiovascular and Metabolic Disease, supported by the Academy of Finland, University of Turku, Turku University Hospital and Åbo Academy.

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 3 – Hyvä terveys ja hyvinvointi

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Yleinen lääketiede

Pääsy asiakirjaan

10.3390/jcm12072684Lisenssi: CC BY

Resistance Training IncreasesFinal published version, 2,24 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202308237754Lisenssi: CC BY

Siteeraa tätä

@article{e96d3a74647b49fe9cf48f8992ede139,

title = "Resistance Training Increases White Matter Density in Frail Elderly Women",

abstract = "We aimed to investigate the effects of maternal obesity on brain structure and metabolism in frail women, and their reversibility in response to exercise. We recruited 37 frail elderly women (20 offspring of lean/normal-weight mothers (OLM) and 17 offspring of obese/overweight mothers (OOM)) and nine non-frail controls to undergo magnetic resonance and diffusion tensor imaging (DTI), positron emission tomography with Fluorine-18-fluorodeoxyglucose (PET), and cognitive function tests (CERAD). Frail women were studied before and after a 4-month resistance training, and controls were studied once. White matter (WM) density (voxel-based morphometry) was higher in OLM than in OOM subjects. Exercise increased WM density in both OLM and OOM in the cerebellum in superior parietal regions in OLM and in cuneal and precuneal regions in OOM. OLM gained more WM density than OOM in response to intervention. No significant results were found from the Freesurfer analysis, nor from PET or DTI images. Exercise has an impact on brain morphology and cognition in elderly frail women.",

keywords = "aged, cognitive dysfunction/diagnosis, diffusion tensor imaging, female, frailty, glucose clamp technique, magnetic resonance imaging, positron-emission tomography, resistance training, VBM",

author = "Marco Bucci and Patricia Iozzo and Harri Merisaari and Ville Huovinen and Heta Lipponen and Katri R{\"a}ikk{\"o}nen and Riitta Parkkola and Minna Salonen and Samuel Sandboge and Eriksson, \{Johan Gunnar\} and Lauri Nummenmaa and Pirjo Nuutila",

note = "Funding Information: This study was supported by grants and funding from the DORIAN EU FP7 (DORIAN–Developmental ORIgins of healthy and unhealthy AgeiNg: The role of maternal obesity, project number 278603), the Academy of Finland, the Finnish Cultural Foundation, the South-Western Finland Cultural Foundation and the Turku University Foundation. Study was conducted within the Centre of Excellence in Cardiovascular and Metabolic Disease, supported by the Academy of Finland, University of Turku, Turku University Hospital and {\AA}bo Academy. Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = apr,

doi = "10.3390/jcm12072684",

language = "English",

volume = "12",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

publisher = "MDPI",

number = "7",

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TY - JOUR

T1 - Resistance Training Increases White Matter Density in Frail Elderly Women

AU - Bucci, Marco

AU - Iozzo, Patricia

AU - Merisaari, Harri

AU - Huovinen, Ville

AU - Lipponen, Heta

AU - Räikkönen, Katri

AU - Parkkola, Riitta

AU - Salonen, Minna

AU - Sandboge, Samuel

AU - Eriksson, Johan Gunnar

AU - Nummenmaa, Lauri

AU - Nuutila, Pirjo

N1 - Funding Information: This study was supported by grants and funding from the DORIAN EU FP7 (DORIAN–Developmental ORIgins of healthy and unhealthy AgeiNg: The role of maternal obesity, project number 278603), the Academy of Finland, the Finnish Cultural Foundation, the South-Western Finland Cultural Foundation and the Turku University Foundation. Study was conducted within the Centre of Excellence in Cardiovascular and Metabolic Disease, supported by the Academy of Finland, University of Turku, Turku University Hospital and Åbo Academy. Publisher Copyright: © 2023 by the authors.

PY - 2023/4

Y1 - 2023/4

N2 - We aimed to investigate the effects of maternal obesity on brain structure and metabolism in frail women, and their reversibility in response to exercise. We recruited 37 frail elderly women (20 offspring of lean/normal-weight mothers (OLM) and 17 offspring of obese/overweight mothers (OOM)) and nine non-frail controls to undergo magnetic resonance and diffusion tensor imaging (DTI), positron emission tomography with Fluorine-18-fluorodeoxyglucose (PET), and cognitive function tests (CERAD). Frail women were studied before and after a 4-month resistance training, and controls were studied once. White matter (WM) density (voxel-based morphometry) was higher in OLM than in OOM subjects. Exercise increased WM density in both OLM and OOM in the cerebellum in superior parietal regions in OLM and in cuneal and precuneal regions in OOM. OLM gained more WM density than OOM in response to intervention. No significant results were found from the Freesurfer analysis, nor from PET or DTI images. Exercise has an impact on brain morphology and cognition in elderly frail women.

AB - We aimed to investigate the effects of maternal obesity on brain structure and metabolism in frail women, and their reversibility in response to exercise. We recruited 37 frail elderly women (20 offspring of lean/normal-weight mothers (OLM) and 17 offspring of obese/overweight mothers (OOM)) and nine non-frail controls to undergo magnetic resonance and diffusion tensor imaging (DTI), positron emission tomography with Fluorine-18-fluorodeoxyglucose (PET), and cognitive function tests (CERAD). Frail women were studied before and after a 4-month resistance training, and controls were studied once. White matter (WM) density (voxel-based morphometry) was higher in OLM than in OOM subjects. Exercise increased WM density in both OLM and OOM in the cerebellum in superior parietal regions in OLM and in cuneal and precuneal regions in OOM. OLM gained more WM density than OOM in response to intervention. No significant results were found from the Freesurfer analysis, nor from PET or DTI images. Exercise has an impact on brain morphology and cognition in elderly frail women.

KW - aged

KW - cognitive dysfunction/diagnosis

KW - diffusion tensor imaging

KW - female

KW - frailty

KW - glucose clamp technique

KW - magnetic resonance imaging

KW - positron-emission tomography

KW - resistance training

KW - VBM

U2 - 10.3390/jcm12072684

DO - 10.3390/jcm12072684

M3 - Article

AN - SCOPUS:85152909478

SN - 2077-0383

VL - 12

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 7

M1 - 2684

ER -

Resistance Training Increases White Matter Density in Frail Elderly Women

Abstrakti

Rahoitus

YK:n kestävän kehityksen tavoitteet

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

Siteeraa tätä