TY - JOUR
T1 - Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases
AU - Mononen, Minna
AU - Saari, Eeva
AU - Hasala, Hannele
AU - Kettunen, Hannu Pekka
AU - Suoranta, Sanna
AU - Nurmi, Hanna
AU - Kärkkäinen, Miia
AU - Selander, Tuomas
AU - Randell, Jukka
AU - Laurikka, Jari
AU - Uibu, Toomas
AU - Koskela, Heikki
AU - Kaarteenaho, Riitta
AU - Purokivi, Minna
N1 - Funding Information:
The authors wish to thank Leena Tuomisto, Elsa Nylund, Johan Söderström, Aki Vainio, Heikki Pautola, Sumu Lehtola, Markku Pekonen, Päivi Torkko, Anssi Ukkonen, Severi Seppälä, Minna Tommola, and Kirsi Hämäläinen for aiding with the data collection.
Funding Information:
This study was supported by the Foundation of the Finnish Anti-Tuberculosis Association, Väinö and Laina Kivi Foundation, The Research Foundation of the Pulmonary Diseases, Jalmari and Rauha Ahokas Foundation, and The Respiratory Foundation of the Kuopio Region. The funding had no role in the design of the study neither in collection, analysis, and interpretation of data or writing the manuscript.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: The disease course of idiopathic pulmonary fibrosis (IPF) is progressive and occasionally, other types of interstitial lung disease (ILD) may progress similarly to IPF. This study aimed to evaluate risk factors for disease progression within 24 months in patients with various ILDs. Methods: This prospective study obtained 97 patients with a suspected ILD who underwent a transbronchial lung cryobiopsy. The extent of several high-resolution computed tomography (HRCT) patterns was assessed. Due to the inclusion criteria the study population presented a low extent of honeycombing and definite usual interstitial pneumonia (UIP) pattern on HRCT suggesting an early stage of ILD. Disease progression within 24 months despite treatment was defined as a relative decline of ≥ 10% in forced vital capacity (FVC), or a relative decline in FVC of ≥ 5% and one of the three additional criteria: (1) a decline in diffusion capacity to carbon monoxide (DLCO) ≥ 15%; (2) increased fibrosis on HRCT; (3) progressive symptoms, or progressive symptoms and increased fibrosis on HRCT. The same definition was utilized in patients with IPF and other ILDs. Risk factors for disease progression were evaluated in a multivariable logistic regression model. Results: Disease progression was revealed in 52% of the patients with ILD, 51% of the patients with IPF, and 53% of the patients with other types of ILD. A high extent of reticulation on HRCT (Odds ratio [OR] 3.11, 95% Confidence interval [CI] 1.21–7.98, P = 0.019) and never smoking (OR 3.11, CI 1.12–8.63, P = 0.029) were associated with disease progression whereas platelet count (OR 2.06 per 100 units increase, CI 0.96–4.45, P = 0.065) did not quite reach statistical significance. Conclusion: Higher extent of reticulation on HRCT and never smoking appeared to associate with the risk of disease progression within 24 months in ILD patients without honeycombing. Approximately half of the patients with ILD revealed disease progression, and similar proportions were observed in patients with IPF and in other types of ILD.
AB - Background: The disease course of idiopathic pulmonary fibrosis (IPF) is progressive and occasionally, other types of interstitial lung disease (ILD) may progress similarly to IPF. This study aimed to evaluate risk factors for disease progression within 24 months in patients with various ILDs. Methods: This prospective study obtained 97 patients with a suspected ILD who underwent a transbronchial lung cryobiopsy. The extent of several high-resolution computed tomography (HRCT) patterns was assessed. Due to the inclusion criteria the study population presented a low extent of honeycombing and definite usual interstitial pneumonia (UIP) pattern on HRCT suggesting an early stage of ILD. Disease progression within 24 months despite treatment was defined as a relative decline of ≥ 10% in forced vital capacity (FVC), or a relative decline in FVC of ≥ 5% and one of the three additional criteria: (1) a decline in diffusion capacity to carbon monoxide (DLCO) ≥ 15%; (2) increased fibrosis on HRCT; (3) progressive symptoms, or progressive symptoms and increased fibrosis on HRCT. The same definition was utilized in patients with IPF and other ILDs. Risk factors for disease progression were evaluated in a multivariable logistic regression model. Results: Disease progression was revealed in 52% of the patients with ILD, 51% of the patients with IPF, and 53% of the patients with other types of ILD. A high extent of reticulation on HRCT (Odds ratio [OR] 3.11, 95% Confidence interval [CI] 1.21–7.98, P = 0.019) and never smoking (OR 3.11, CI 1.12–8.63, P = 0.029) were associated with disease progression whereas platelet count (OR 2.06 per 100 units increase, CI 0.96–4.45, P = 0.065) did not quite reach statistical significance. Conclusion: Higher extent of reticulation on HRCT and never smoking appeared to associate with the risk of disease progression within 24 months in ILD patients without honeycombing. Approximately half of the patients with ILD revealed disease progression, and similar proportions were observed in patients with IPF and in other types of ILD.
KW - Disease progression
KW - Idiopathic pulmonary fibrosis (IPF)
KW - Interstitial lung disease (ILD)
KW - Radiology
U2 - 10.1186/s12890-022-02105-9
DO - 10.1186/s12890-022-02105-9
M3 - Article
C2 - 35965320
AN - SCOPUS:85135878345
SN - 1471-2466
VL - 22
JO - Bmc Pulmonary Medicine
JF - Bmc Pulmonary Medicine
M1 - 313
ER -