Risk Factor Profile in Youth, Genetic Risk, and Adulthood Cognitive Function: The Cardiovascular Risk in Young Finns Study

Feitong Wu; Ari Ahola-Olli; Katja Pahkala; Juuso O. Hakala; Markus Juonala; Pia Salo; Terho Lehtimäki; Nina Hutri-Kähönen; Mika Kähönen; Tomi Laitinen; Päivi Tossavainen; Leena Taittonen; Eero Jokinen; Jorma S.A. Viikari; Costan G. Magnussen; Olli T. Raitakari; Suvi P. Rovio

doi:10.1159/000524986

Risk Factor Profile in Youth, Genetic Risk, and Adulthood Cognitive Function: The Cardiovascular Risk in Young Finns Study

Feitong Wu
, Ari Ahola-Olli
, Katja Pahkala
, Juuso O. Hakala
, Markus Juonala
, Pia Salo
, Terho Lehtimäki
, Nina Hutri-Kähönen
, Mika Kähönen
, Tomi Laitinen
, Päivi Tossavainen
, Leena Taittonen
, Eero Jokinen
, Jorma S.A. Viikari
, Costan G. Magnussen
, Olli T. Raitakari
, Suvi P. Rovio^*

^*Tämän työn vastaava kirjoittaja

Kliinisen kemian yksikkö

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

1 Sitaatiot (Scopus)

8 Lataukset (Pure)

Abstrakti

Introduction: The role of risk factor profile in childhood and adolescence on adulthood cognitive function and whether it differs by genetic risk is still obscure. To bring this evidence, we determined cognitive domain-specific youth risk factor profiles leveraging the childhood/adolescence data from the Cardiovascular Risk in Young Finns Study and examined whether genetic propensity for poor cognitive function modifies the association between the risk profiles and adulthood cognitive function. Methods: From 1980, a population-based cohort of 3,596 children (age 3-18 years) has been repeatedly followed up for 31 years. Computerized cognitive test measuring (1) memory and learning, (2) short-term working memory, (3) reaction time, and (4) information processing was performed for 2,026 participants (age 34-49 years). Cognitive domain-specific youth risk profile scores, including physical and environmental factors, were assessed from the data collected at baseline and categorized into favourable, intermediate, and unfavourable. A polygenic risk score for a poor cognitive function was categorized into low, intermediate, and high risk. Results: At all genetic risk levels, a favourable youth risk factor profile is associated with better learning and memory, short-term working memory, and information processing compared to unfavourable risk profile (e.g., β = 0.501 SD, 95% CI: 0.043-0.959 for memory and learning among participants with high genetic risk). However, no significant interactions were observed between the youth risk factor profile score and genetic propensity for any cognitive domain (p > 0.299 for all). Conclusion: A favourable youth risk factor profile may be beneficial for cognitive function in adulthood, irrespective of genetic propensity for poor cognitive function.

Alkuperäiskieli	Englanti
Sivut	201-211
Sivumäärä	11
Julkaisu	Neuroepidemiology
Vuosikerta	56
Numero	3
DOI - pysyväislinkit	https://doi.org/10.1159/000524986
Tila	Julkaistu - elok. 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

The Young Finns Study has been financially supported by the Academy of Finland: Grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (Grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (Grant 755320 for TAXINOMISIS and grant 848146 ToAition); European Research Council (Grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation. F.W. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1158661). K.P. is supported by the Academy of Finland research fellowship (322112). We thank Johanna Ikonen (Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland) for compiling data for the analyses and for statistical advice. We thank all the participants involved in the Cardiovascular Risk in Young Finns Study. The Young Finns Study has been financially supported by the Academy of Finland: Grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (Grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (Grant 755320 for TAXINOMISIS and grant 848146 ToAition); European Research Council (Grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation. F.W. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1158661). K.P. is supported by the Academy of Finland research fellowship (322112).

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 3 – Hyvä terveys ja hyvinvointi

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Epidemiology
Clinical Neurology

Pääsy asiakirjaan

10.1159/000524986

Risk Factor Profile in Youth, Genetic Risk, and Adulthood Cognitive Function_2022
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
Accepted author manuscript, 2,1 MBLisenssi: Unspecified

https://urn.fi/URN:NBN:fi:tuni-202208246677Lisenssi: Unspecified

Siteeraa tätä

Wu, F., Ahola-Olli, A., Pahkala, K., Hakala, J. O., Juonala, M., Salo, P., Lehtimäki, T., Hutri-Kähönen, N., Kähönen, M., Laitinen, T., Tossavainen, P., Taittonen, L., Jokinen, E., Viikari, J. S. A., Magnussen, C. G., Raitakari, O. T., & Rovio, S. P. (2022). Risk Factor Profile in Youth, Genetic Risk, and Adulthood Cognitive Function: The Cardiovascular Risk in Young Finns Study. Neuroepidemiology, 56(3), 201-211. https://doi.org/10.1159/000524986

@article{73cf3de7c7f64fff88fb1c4a6026c2eb,

title = "Risk Factor Profile in Youth, Genetic Risk, and Adulthood Cognitive Function: The Cardiovascular Risk in Young Finns Study",

abstract = "Introduction: The role of risk factor profile in childhood and adolescence on adulthood cognitive function and whether it differs by genetic risk is still obscure. To bring this evidence, we determined cognitive domain-specific youth risk factor profiles leveraging the childhood/adolescence data from the Cardiovascular Risk in Young Finns Study and examined whether genetic propensity for poor cognitive function modifies the association between the risk profiles and adulthood cognitive function. Methods: From 1980, a population-based cohort of 3,596 children (age 3-18 years) has been repeatedly followed up for 31 years. Computerized cognitive test measuring (1) memory and learning, (2) short-term working memory, (3) reaction time, and (4) information processing was performed for 2,026 participants (age 34-49 years). Cognitive domain-specific youth risk profile scores, including physical and environmental factors, were assessed from the data collected at baseline and categorized into favourable, intermediate, and unfavourable. A polygenic risk score for a poor cognitive function was categorized into low, intermediate, and high risk. Results: At all genetic risk levels, a favourable youth risk factor profile is associated with better learning and memory, short-term working memory, and information processing compared to unfavourable risk profile (e.g., β = 0.501 SD, 95\% CI: 0.043-0.959 for memory and learning among participants with high genetic risk). However, no significant interactions were observed between the youth risk factor profile score and genetic propensity for any cognitive domain (p > 0.299 for all). Conclusion: A favourable youth risk factor profile may be beneficial for cognitive function in adulthood, irrespective of genetic propensity for poor cognitive function.",

keywords = "CANTAB, Childhood factors, Cognitive function, Cohort, Polygenic risk score",

author = "Feitong Wu and Ari Ahola-Olli and Katja Pahkala and Hakala, \{Juuso O.\} and Markus Juonala and Pia Salo and Terho Lehtim{\"a}ki and Nina Hutri-K{\"a}h{\"o}nen and Mika K{\"a}h{\"o}nen and Tomi Laitinen and P{\"a}ivi Tossavainen and Leena Taittonen and Eero Jokinen and Viikari, \{Jorma S.A.\} and Magnussen, \{Costan G.\} and Raitakari, \{Olli T.\} and Rovio, \{Suvi P.\}",

note = "Funding Information: The Young Finns Study has been financially supported by the Academy of Finland: Grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (Grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrj{\"o} Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (Grant 755320 for TAXINOMISIS and grant 848146 ToAition); European Research Council (Grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation. F.W. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1158661). K.P. is supported by the Academy of Finland research fellowship (322112). We thank Johanna Ikonen (Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland) for compiling data for the analyses and for statistical advice. We thank all the participants involved in the Cardiovascular Risk in Young Finns Study. Funding Information: The Young Finns Study has been financially supported by the Academy of Finland: Grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (Grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrj{\"o} Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (Grant 755320 for TAXINOMISIS and grant 848146 ToAition); European Research Council (Grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation. F.W. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1158661). K.P. is supported by the Academy of Finland research fellowship (322112). Publisher Copyright: {\textcopyright} 2022 S. Karger AG, Basel.",

year = "2022",

month = aug,

doi = "10.1159/000524986",

language = "English",

volume = "56",

pages = "201--211",

journal = "Neuroepidemiology",

issn = "0251-5350",

publisher = "S. Karger AG",

number = "3",

}

Wu, F, Ahola-Olli, A, Pahkala, K, Hakala, JO, Juonala, M, Salo, P, Lehtimäki, T, Hutri-Kähönen, N, Kähönen, M, Laitinen, T, Tossavainen, P, Taittonen, L, Jokinen, E, Viikari, JSA, Magnussen, CG, Raitakari, OT & Rovio, SP 2022, 'Risk Factor Profile in Youth, Genetic Risk, and Adulthood Cognitive Function: The Cardiovascular Risk in Young Finns Study', Neuroepidemiology, Vuosikerta 56, Nro 3, Sivut 201-211. https://doi.org/10.1159/000524986

TY - JOUR

T1 - Risk Factor Profile in Youth, Genetic Risk, and Adulthood Cognitive Function

T2 - The Cardiovascular Risk in Young Finns Study

AU - Wu, Feitong

AU - Ahola-Olli, Ari

AU - Pahkala, Katja

AU - Hakala, Juuso O.

AU - Juonala, Markus

AU - Salo, Pia

AU - Lehtimäki, Terho

AU - Hutri-Kähönen, Nina

AU - Kähönen, Mika

AU - Laitinen, Tomi

AU - Tossavainen, Päivi

AU - Taittonen, Leena

AU - Jokinen, Eero

AU - Viikari, Jorma S.A.

AU - Magnussen, Costan G.

AU - Raitakari, Olli T.

AU - Rovio, Suvi P.

N1 - Funding Information: The Young Finns Study has been financially supported by the Academy of Finland: Grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (Grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (Grant 755320 for TAXINOMISIS and grant 848146 ToAition); European Research Council (Grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation. F.W. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1158661). K.P. is supported by the Academy of Finland research fellowship (322112). We thank Johanna Ikonen (Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland) for compiling data for the analyses and for statistical advice. We thank all the participants involved in the Cardiovascular Risk in Young Finns Study. Funding Information: The Young Finns Study has been financially supported by the Academy of Finland: Grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (Grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (Grant 755320 for TAXINOMISIS and grant 848146 ToAition); European Research Council (Grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation. F.W. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1158661). K.P. is supported by the Academy of Finland research fellowship (322112). Publisher Copyright: © 2022 S. Karger AG, Basel.

PY - 2022/8

Y1 - 2022/8

N2 - Introduction: The role of risk factor profile in childhood and adolescence on adulthood cognitive function and whether it differs by genetic risk is still obscure. To bring this evidence, we determined cognitive domain-specific youth risk factor profiles leveraging the childhood/adolescence data from the Cardiovascular Risk in Young Finns Study and examined whether genetic propensity for poor cognitive function modifies the association between the risk profiles and adulthood cognitive function. Methods: From 1980, a population-based cohort of 3,596 children (age 3-18 years) has been repeatedly followed up for 31 years. Computerized cognitive test measuring (1) memory and learning, (2) short-term working memory, (3) reaction time, and (4) information processing was performed for 2,026 participants (age 34-49 years). Cognitive domain-specific youth risk profile scores, including physical and environmental factors, were assessed from the data collected at baseline and categorized into favourable, intermediate, and unfavourable. A polygenic risk score for a poor cognitive function was categorized into low, intermediate, and high risk. Results: At all genetic risk levels, a favourable youth risk factor profile is associated with better learning and memory, short-term working memory, and information processing compared to unfavourable risk profile (e.g., β = 0.501 SD, 95% CI: 0.043-0.959 for memory and learning among participants with high genetic risk). However, no significant interactions were observed between the youth risk factor profile score and genetic propensity for any cognitive domain (p > 0.299 for all). Conclusion: A favourable youth risk factor profile may be beneficial for cognitive function in adulthood, irrespective of genetic propensity for poor cognitive function.

AB - Introduction: The role of risk factor profile in childhood and adolescence on adulthood cognitive function and whether it differs by genetic risk is still obscure. To bring this evidence, we determined cognitive domain-specific youth risk factor profiles leveraging the childhood/adolescence data from the Cardiovascular Risk in Young Finns Study and examined whether genetic propensity for poor cognitive function modifies the association between the risk profiles and adulthood cognitive function. Methods: From 1980, a population-based cohort of 3,596 children (age 3-18 years) has been repeatedly followed up for 31 years. Computerized cognitive test measuring (1) memory and learning, (2) short-term working memory, (3) reaction time, and (4) information processing was performed for 2,026 participants (age 34-49 years). Cognitive domain-specific youth risk profile scores, including physical and environmental factors, were assessed from the data collected at baseline and categorized into favourable, intermediate, and unfavourable. A polygenic risk score for a poor cognitive function was categorized into low, intermediate, and high risk. Results: At all genetic risk levels, a favourable youth risk factor profile is associated with better learning and memory, short-term working memory, and information processing compared to unfavourable risk profile (e.g., β = 0.501 SD, 95% CI: 0.043-0.959 for memory and learning among participants with high genetic risk). However, no significant interactions were observed between the youth risk factor profile score and genetic propensity for any cognitive domain (p > 0.299 for all). Conclusion: A favourable youth risk factor profile may be beneficial for cognitive function in adulthood, irrespective of genetic propensity for poor cognitive function.

KW - CANTAB

KW - Childhood factors

KW - Cognitive function

KW - Cohort

KW - Polygenic risk score

U2 - 10.1159/000524986

DO - 10.1159/000524986

M3 - Article

C2 - 35552281

AN - SCOPUS:85135597942

SN - 0251-5350

VL - 56

SP - 201

EP - 211

JO - Neuroepidemiology

JF - Neuroepidemiology

IS - 3

ER -

Risk Factor Profile in Youth, Genetic Risk, and Adulthood Cognitive Function: The Cardiovascular Risk in Young Finns Study

Abstrakti

Rahoitus

YK:n kestävän kehityksen tavoitteet

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

Siteeraa tätä