RNA-protein interactions in vivo: Global gets specific

Minna-Liisa Änkö; Karla M. Neugebauer

doi:10.1016/j.tibs.2012.02.005

RNA-protein interactions in vivo: Global gets specific

Minna-Liisa Änkö^*
, Karla M. Neugebauer

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Katsausartikkeli › vertaisarvioitu

77 Sitaatiot (Scopus)

Abstrakti

RNA-binding proteins (RBPs) impact every process in the cell; they act as splicing and polyadenylation factors, transport and localization factors, stabilizers and destabilizers, modifiers, and chaperones. RNA-binding capacity can be attributed to numerous protein domains that bind a limited repertoire of short RNA sequences. How is specificity achieved in cells? Here we focus on recent advances in determining the RNA-binding properties of proteins in vivo and compare these to in vitro determinations, highlighting insights into how endogenous RNA molecules are recognized and regulated. We also discuss the crucial contribution of structural determinations for understanding RNA-binding specificity and mechanisms.

Alkuperäiskieli	Englanti
Sivut	255-262
Sivumäärä	8
Julkaisu	Trends in Biochemical Sciences
Vuosikerta	37
Numero	7
DOI - pysyväislinkit	https://doi.org/10.1016/j.tibs.2012.02.005
Tila	Julkaistu - heinäk. 2012
Julkaistu ulkoisesti	Kyllä
OKM-julkaisutyyppi	A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Rahoitus

We thank Michael Hiller and members of our laboratory for helpful discussions and apologize to those authors whose work we could not cite owing to space limitations. We are grateful for support from the Max Planck Society (to K.M.N.), the Deutsche Forschungsgemeinschaft (NE909/3-1 to K.M.N.), the Helsingin Sanomain Foundation, the Sigrid Juselius Foundation and the Jane and Aatos Erkko Foundation (to M-L.Ä.).

!!ASJC Scopus subject areas

Biochemistry
Molecular Biology

Pääsy asiakirjaan

10.1016/j.tibs.2012.02.005

Siteeraa tätä

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title = "RNA-protein interactions in vivo: Global gets specific",

abstract = "RNA-binding proteins (RBPs) impact every process in the cell; they act as splicing and polyadenylation factors, transport and localization factors, stabilizers and destabilizers, modifiers, and chaperones. RNA-binding capacity can be attributed to numerous protein domains that bind a limited repertoire of short RNA sequences. How is specificity achieved in cells? Here we focus on recent advances in determining the RNA-binding properties of proteins in vivo and compare these to in vitro determinations, highlighting insights into how endogenous RNA molecules are recognized and regulated. We also discuss the crucial contribution of structural determinations for understanding RNA-binding specificity and mechanisms.",

author = "Minna-Liisa {\"A}nk{\"o} and Neugebauer, \{Karla M.\}",

note = "Funding Information: We thank Michael Hiller and members of our laboratory for helpful discussions and apologize to those authors whose work we could not cite owing to space limitations. We are grateful for support from the Max Planck Society (to K.M.N.), the Deutsche Forschungsgemeinschaft (NE909/3-1 to K.M.N.), the Helsingin Sanomain Foundation, the Sigrid Juselius Foundation and the Jane and Aatos Erkko Foundation (to M-L.{\"A}.).",

year = "2012",

month = jul,

doi = "10.1016/j.tibs.2012.02.005",

language = "English",

volume = "37",

pages = "255--262",

journal = "Trends in Biochemical Sciences",

issn = "0968-0004",

publisher = "Elsevier",

number = "7",

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TY - JOUR

T1 - RNA-protein interactions in vivo

T2 - Global gets specific

AU - Änkö, Minna-Liisa

AU - Neugebauer, Karla M.

N1 - Funding Information: We thank Michael Hiller and members of our laboratory for helpful discussions and apologize to those authors whose work we could not cite owing to space limitations. We are grateful for support from the Max Planck Society (to K.M.N.), the Deutsche Forschungsgemeinschaft (NE909/3-1 to K.M.N.), the Helsingin Sanomain Foundation, the Sigrid Juselius Foundation and the Jane and Aatos Erkko Foundation (to M-L.Ä.).

PY - 2012/7

Y1 - 2012/7

N2 - RNA-binding proteins (RBPs) impact every process in the cell; they act as splicing and polyadenylation factors, transport and localization factors, stabilizers and destabilizers, modifiers, and chaperones. RNA-binding capacity can be attributed to numerous protein domains that bind a limited repertoire of short RNA sequences. How is specificity achieved in cells? Here we focus on recent advances in determining the RNA-binding properties of proteins in vivo and compare these to in vitro determinations, highlighting insights into how endogenous RNA molecules are recognized and regulated. We also discuss the crucial contribution of structural determinations for understanding RNA-binding specificity and mechanisms.

AB - RNA-binding proteins (RBPs) impact every process in the cell; they act as splicing and polyadenylation factors, transport and localization factors, stabilizers and destabilizers, modifiers, and chaperones. RNA-binding capacity can be attributed to numerous protein domains that bind a limited repertoire of short RNA sequences. How is specificity achieved in cells? Here we focus on recent advances in determining the RNA-binding properties of proteins in vivo and compare these to in vitro determinations, highlighting insights into how endogenous RNA molecules are recognized and regulated. We also discuss the crucial contribution of structural determinations for understanding RNA-binding specificity and mechanisms.

U2 - 10.1016/j.tibs.2012.02.005

DO - 10.1016/j.tibs.2012.02.005

M3 - Review Article

C2 - 22425269

AN - SCOPUS:84862883971

SN - 0968-0004

VL - 37

SP - 255

EP - 262

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 7

ER -

RNA-protein interactions in vivo: Global gets specific

Abstrakti

Rahoitus

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

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