Screening for prostate cancer: evidence, ongoing trials, policies and knowledge gaps

Ola Bratt, Anssi Auvinen, Rebecka Arnsrud Godtman, Mikael Hellström, Jonas Hugosson, Hans Lilja, Jonas Wallström, Monique J. Roobol

Tutkimustuotos: Katsausartikkelivertaisarvioitu

9 Sitaatiot (Scopus)
2 Lataukset (Pure)

Abstrakti

Long-term screening with serum prostate-specific antigen (PSA) and systematic prostate biopsies can reduce prostate cancer mortality but leads to unacceptable overdiagnosis. Over the past decade, diagnostic methods have improved and the indolent nature of low-grade prostate cancer has been established. These advances now enable more selective detection of potentially lethal prostate cancer. This non-systematic review summarises relevant diagnostic advances, previous and ongoing screening trials, healthcare policies and important remaining knowledge gaps. Evidence synthesis and conclusions: The strong association between low serum PSA values and minimal long-term risk of prostate cancer death allows for adjusting screening intervals. Use of risk calculators, biomarkers and MRI to select men with a raised PSA value for biopsy and lesion-targeting rather than systematic prostate biopsies reduce the detection of low-grade cancer and thereby overdiagnosis. These improvements recently led the European Union to recommend its member states to evaluate the feasibility and effectiveness of organised screening programmes for prostate cancer. Nonetheless, important knowledge gaps remain such as the performance of modern diagnostic methods in long-term screening programmes and their impact on mortality. The knowledge gaps are currently being addressed in three large randomised screening trials. Population-based pilot programmes will contribute critical practical experience.

AlkuperäiskieliEnglanti
Artikkelie000039
JulkaisuBMJ Oncology
Vuosikerta2
Numero1
DOI - pysyväislinkit
TilaJulkaistu - 20 huhtik. 2023
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

  • Jufo-taso 1

!!ASJC Scopus subject areas

  • Oncology

Sormenjälki

Sukella tutkimusaiheisiin 'Screening for prostate cancer: evidence, ongoing trials, policies and knowledge gaps'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.

Siteeraa tätä